Appendix Table 25KQ4 Syncope—Comparative effectiveness of medical therapies with or without ACEI or ARBs for stable ischemic heart disease

Study, yearStudy DesignPopulationOutcome/DefinitionGroupEvents, n/NEvents, “X”R (95% CI)
HOPE, 200038RCTCAD, Stroke, PVD or DM + 1 CV Risk FactorSyncopeRamipril 10mg/d
Placebo
3/4645
1/4652
NR
PART-2, 200041RCTMI, angina with confirmed CAD, TIA or ICNRRamipril 5–10mg/d
Placebo
NRNR
SCAT, 200042RCTCoronary atherosclerosis in >3 major arteries, elevated cholesterolNREnalapril 20mg/d
Placebo
NRNR
EUROPA, 200343RCTCAD (previous MI, revasc. or >70% coronary artery narrowing) without HFNRPerindopril 8mg/d
Placebo
NRNR
Kondo et al, 200344RCTH/o coronary intervention with no significant stenosis on 6 mo f/o angiographyNRCandesartan 4mg/d
Control
NRNR
CAMELOT, 200445RCTPCI or chest pain requiring coronary angiographyNREnalapril 20mg/d
Amlodipine 10mg/d
Placebo
NRNR
JMIC-B, 200446RCTHypertension and CADNRACEI
Nifedipine 10–20mg/d
NRNR
PEACE, 200447RCTDocumented CADSyncopeTrandolapril 4mg/d
Placebo
200/4158
161/4132
NR
FOSIDIAL, 200648RCTHemodialysis and LVHNRFosinopril 20mg/d
Placebo
NRNR
Takahashi et al, 200649RCTChronic maintenance hemodialysisNRCandesartan 4–8mg/d
Control
NRNR
SMILE-ISCHEMIA, 200750RCTMI within 6 weeksNRZofenopril 60mg/d
Placebo
NRNR
TRANSCEND, 200851RCTCAD, Cerebrovascular disease, PVD, or DM + end-organ damageNRTelmisartan 80mg/d
Placebo
NRNR

= Data are reported as “serious adverse events” found within the New Drug Application from www​.fda.gov.

= Patients in the ACEI group were given enalapril 5–10mg/d, imidapril 5–10mg/d, or lisinopril 10–20mg/d;

From: Appendix C, Additional Evidence Tables and Analyses

Cover of Comparative Effectiveness of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard Medical Therapy for Treating Stable Ischemic Heart Disease
Comparative Effectiveness of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Blockers Added to Standard Medical Therapy for Treating Stable Ischemic Heart Disease [Internet].
Comparative Effectiveness Reviews, No. 18.
Coleman CI, Baker WL, Kluger J, et al.

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