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Whitlock EP, Garlitz BA, Harris EL, et al. Screening for Hereditary Hemochromatosis: A Focused Evidence Review [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006 Aug. (Evidence Syntheses, No. 43.)

Appendix A

Figure 1. Search results and article flow by key question.

Figure 1. Search results and article flow by key question

Figure 2. Abstract and article review process for hemochromatosis.
Figure 2. Abstract and article review process for hemochromatosis.

Figure 2. Abstract and article review process for hemochromatosis

Search strategies

Databases: Medline, DARE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials

Dates searched: 1966–February 2005

Key Question 1

1.

HEMOCHROMATOSIS/

2.

hemochromatosis.ti,ab.

3.

haemochromatosis.ti,ab.

4.

Iron Overload/

5.

iron overload.ti,ab.

6.

c282y.ti,ab.

7.

1 or 2 or 3 or 4 or 5 or 6

8.

cohort studies/ or longitudinal studies/ or follow-up studies/ or prospective studies/

9.

follow-up stud$.ti,ab.

10.

cohort stud$.ti,ab.

11.

longitudinal$.ti,ab.

12.

prospective$.ti,ab.

13.

INCIDENCE/

14.

incidence.ti,ab.

15.

predict$.ti,ab,hw.

16.

natural history.ti,ab.

17.

penetrance/

18.

penetran$.ti,ab.

19.

clinical expression$.ti,ab.

20.

clinical presentation$.ti,ab.

21.

clinical consequence$.ti,ab.

22.

clinical feature$.ti,ab.

23.

clinical manifestation$.ti,ab.

24.

8 or 9 or 10 or 11 or 12 or 13 or 14 or 15 or 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23

25.

7 and 24

26.

limit 25 to (humans and english language)

27.

limit 26 to “all child (0 to 18 years)”

28.

limit 27 to “all adult (19 plus years)”

29.

27 not 28

30.

26 not 29

31.

(editorial or letter or news).pt.

32.

30 not 31

Key Question 2

1.

HEMOCHROMATOSIS/

2.

hemochromatosis.ti,ab.)

3.

haemochromatosis.ti,ab.

4.

Iron Overload/

5.

iron overload.ti,ab.

6.

1 or 2 or 3 or 4 or 5

7.

BLOODLETTING/

8.

blood lett$.ti,ab.)

9.

PHLEBOTOMY/

10.

phlebotom$.ti,ab.

11.

venesect$.ti,ab.

12.

7 or 8 or 9 or 10 or 11

13.

6 and 12

14.

Hemochromatosis/th [Therapy]

15.

Iron Overload/th [Therapy]

16.

13 or 14 or 15

17.

limit 16 to (humans and english language)

18.

limit 17 to “all child (0 to 18 years)”

19.

limit 18 to “all adult (19 plus years)”

20.

18 not 19

21.

17 not 20

22.

(editorial or letter or news).pt.

23.

21 not 22

Key Question 3

1.

HEMOCHROMATOSIS/

2.

hemochromatosis.ti,ab.

3.

haemochromatosis.ti,ab.

4.

1 or 2 or 3

5.

family/ or nuclear family/ or parents/ or fathers/ or mothers/ or siblings/

6.

(family or families).ti,ab.

7.

(relative or relatives).ti,ab.

8.

sibling$.ti,ab.

9.

(mother$ or father$).ti,ab.

10.

parent$.ti,ab.

11.

5 or 6 or 7 or 8 or 9 or 10

12.

screen$.ti,ab,hw.

13.

diagnos$.ti,ab,hw.

14.

di.fs.

15.

12 or 13 or 14

16.

4 and 11 and 15

17.

target$.ti,ab.

18.

4 and 15 and 17

19.

Risk Factors/

20.

risk factor$.ti,ab.

21.

increased risk$.ti,ab.

22.

high risk.ti,ab.

23.

prognostic factor$.ti,ab.

24.

19 or 20 or 21 or 22 or 23

25.

4 and 24

26.

cascad$.ti,ab.

27.

4 and 26

28.

Liver Function Tests/

29.

liver function.ti,ab.

30.

(abnormal$ adj3 liver).ti,ab.

31.

(increased adj3 liver).ti,ab.

32.

(elevate$ adj3 liver).ti,ab.

33.

28 or 29 or 30 or 31 or 32

34.

4 and 33

35.

16 or 18 or 25 or 27 or 34

36.

limit 35 to english language

37.

limit 36 to humans

38.

limit 37 to “all child (0 to 18 years)”

39.

limit 38 to “all adult (19 plus years)”

40.

38 not 39

41.

37 not 40

42.

(editorial or letter or news).pt.

43.

41 not 42

Background

1.

hemochromatosis)

2.

hemochromatosis.ti,ab.

3.

haemochromatosis.ti,ab.

4.

1 or 2 or 3

5.

PREVALENCE/

6.

prevalen$.ti,ab.

7.

5 or 6

8.

4 and 7

9.

HEMOCHROMATOSIS/ep [Epidemiology]

10.

mo.fs.

11.

“Cause of Death”/

12.

Survival Rate/

13.

Life Expectancy/

14.

mortality.ti,ab.

15.

10 or 11 or 12 or 13 or 14

16.

4 and 15

17.

8 or 9 or 16

18.

limit 17 to english language

19.

limit 18 to humans

20.

limit 19 to “all child (0 to 18 years)”

21.

limit 20 to “all adult (19 plus years)”

22.

20 not 21

23.

19 not 22

24.

(letter or news or editorial).pt.

25.

23 not 24

Cover of Screening for Hereditary Hemochromatosis
Screening for Hereditary Hemochromatosis: A Focused Evidence Review [Internet].
Evidence Syntheses, No. 43.
Whitlock EP, Garlitz BA, Harris EL, et al.

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