Table 63

Summary of study characteristics for cognitive remediation.

Cognitive remediation vs. any controlCognitive remediation vs. standard careCognitive remediation vs. other active treatments
k (total N)17108410(522)9(605)
Study IDBELLUCCI2002
Hadaslidor2001
HOGARTY2004
Medalia1998
Medalia2000
PENADES2006
SILVERSTEIN2005 a
SPAULDING1999
TWAMLEY2008
VANDERGAAG2002
VELLIGAN2000
VELLIGAN2002
VELLIGAN2008A
VELLIGAN2008B
Wykes19991999
WYKES2007A
WYKES2007B
BELLUCCI2002
Medalia2000
SILVERSTEIN2005 a
TWAMLEY2008
VELLIGAN2000
VELLIGAN2002
VELLIGAN2008A
VELLIGAN2008B
WYKES2007A
WYKES2007B
Hadaslidor2001
HOGARTY2004
Medalia1998
PENADES2006
SPAULDING1999
VANDERGAAG2002
VELLIGAN2008A
VELLIGAN2008B
Wykes1999
Diagnosis83%–100%
Schizophrenia or other related diagnoses (DSM or ICD-10)
95%–100%
Schizophrenia or other related diagnoses (DSM or ICD-10)
83%–100%
Schizophrenia or other related diagnoses (DSM or ICD-10)
Baseline severityBPRS total: Mean (SD) ~30(4) Medalia1998
Mean (SD) ~37(9) WYKES2007B
BPRS total: Mean (SD) ~37(9) WYKES2007BBPRS total: Mean (SD) ~30(4) Medalia1998
PANSS total: Mean (SD) ~60(15) WYKES2007APANSS total: Mean (SD) ~60(15) WYKES2007A
Length of treatmentRange: 5 to 104 weeksRange: 5 to 104 weeksRange: 6 to 104 weeks
Length of FUUp to 3 months
TWAMLEY2008
WYKES2007B
Up to 3 months
TWAMLEY2008
WYKES2007B
Up to 6 months
PENADES2006
Wykes19991999
WYKES2007A
Up to 6 months
WYKES2007A
Up to 6 months
PENADES2006
Wykes19991999
Up to 12 months
HOGARTY2004
Up to 12 months
HOGARTY2004
SettingInpatient b
Medalia1998
Medalia2000
SILVERSTEIN2005
SPAULDING1999
VANDERGAAG2002
WYKES2007B
Inpatient b
Medalia2000
SILVERSTEIN2005
WYKES2007B
Inpatient b
Medalia1998
SPAULDING1999
VANDERGAAG2002
Outpatient
BELLUCCI2002
HOGARTY2004
VELLIGAN2000 c
VELLIGAN2002
VELLIGAN2008A
VELLIGAN2008B
Wykes19991999
WYKES2007A
Outpatient
BELLUCCI2002
VELLIGAN2000 c
VELLIGAN2002
VELLIGAN2008A
VELLIGAN2008B
WYKES2007A
Outpatient
HOGARTY2004
VELLIGAN2008A
VELLIGAN2008B
Wykes19991999
I
Day rehabilitation centre
Hadaslidor2001
Day rehabilitation centre
Hadaslidor2001

a The study included an attentional module for both cognitive remediation and waiting list control participants. The attentional module started after the completion of the cognitive remediation intervention and after testing at time point two. Only data from time point two was used in the analysis as this represents cognitive remediation versus standard care alone.

b Inpatient included inpatient rehabilitation units

c Participants in the Velligan papers were recruited following discharge from an inpatient setting

From: 8, Psychological therapy and psychosocial interventions in the treatment and management of schizophrenia

Cover of Schizophrenia
Schizophrenia: Core Interventions in the Treatment and Management of Schizophrenia in Primary and Secondary Care (Update) [Internet].
NICE Clinical Guidelines, No. 82.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2009 Mar.
Copyright © 2009, National Collaborating Centre for Mental Health.

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