Table 17

Summary of study characteristics for zotepine versus a FGA (acute treatment).

Zotepine vs. haloperidolZotepine vs. another FGA
k (total N)5 (386)2 (146)
Study IDBarnas1987
Fleischhacker1989
Klieser1996
Petit1996
KnollCTR (StudyZT4002)
Cooper1999a
Dieterle1999
Diagnostic criteriaDSM-III, DSM-III-R, ICD-9DSM-III-R, ICD-9
SettingInpatientMostly inpatient
Duration of treatmentShort-term: 4–8 weeks
Medium-term: 26 weeks
Short-term: 4–8 weeks
Medication dose (mg/day)ZOT: 94–309 (range of means); 150–300 (range)
HAL: 4–15 (range of means); 10–20 (range)
ZOT: 241 (mean); 300 (max)
CHL: 600 (max)
PER: 348 (mean)

From: 6, Pharmacological interventions in the treatment and management of schizophrenia

Cover of Schizophrenia
Schizophrenia: Core Interventions in the Treatment and Management of Schizophrenia in Primary and Secondary Care (Update) [Internet].
NICE Clinical Guidelines, No. 82.
National Collaborating Centre for Mental Health (UK).
Leicester (UK): British Psychological Society; 2009 Mar.
Copyright © 2009, National Collaborating Centre for Mental Health.

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