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Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy: Final Report Update 2 [Internet]

Drug Class Review: Antiepileptic Drugs for Indications Other Than Epilepsy: Final Report Update 2 [Internet]

Drug Class Reviews - Oregon Health & Science University

Version: October 2008

Methods

Bipolar disorder (any) diagnosed according to Diagnostic and Statistical Manual of Mental Disorders criteria.

Evidence Tables

Randomized-controlled trials in patients with bipolar disorders

Introduction

Antiepileptic drugs have been used beyond treatment of seizure disorders since the 1960s, when they first became available. All antiepileptic drugs can depress abnormal neuronal discharge in the central nervous system. Their exact mechanisms of action, however, remain uncertain. Several mechanisms have been proposed, such as potentiation of gamma-aminobutyric acid–mediated inhibition, inactivation of sodium or calcium channels, and blockade of N-methyl-D-aspartate receptors. Inactivation of sodium channels by antiepileptic drugs may reduce ectopic discharge from injured nerve endings and neurons of dorsal root ganglia.

Results

Our literature searches identified 2308 new citations for Update 2: 540 from the Cochrane Central Register of Controlled Trials, 25 from the Cochrane Database of Systematic Reviews, 1254 from Medline, 441 from PsychINFO, and 48 from hand-searching. We received no new pharmaceutical company dossier submissions for Update 2. Figure 1 shows results of our study selection process for Update 2. Appendix F lists the excluded studies.

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