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Screening For Asymptomatic Carotid Artery Stenosis [Internet]

Cerebrovascular disease is the third leading cause of death in the U.S. The proportion of all strokes attributable to previously asymptomatic carotid stenosis is low. In 1996, the United States Preventive Services Task Force concluded that there was insufficient evidence to recommend for or against screening of asymptomatic persons for CAS using physical exam or carotid ultrasound.

Evidence Syntheses - Agency for Healthcare Research and Quality (US).

Version: December 2007
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Drug Class Review: Beta Adrenergic Blockers: Final Report Update 4 [Internet]

Beta blockers inhibit the chronotropic, inotropic, and vasoconstrictor responses to the catecholamines, epinephrine, and norepinephrine. Beta blockers differ in their duration of effect (3 hours to 22 hours), the types of beta receptors they block (β1-selective or β1/β2-nonselective), whether they are simultaneously capable of exerting low level heart rate increases (intrinsic sympathomimetic activity [ISA]), and in whether they provide additional blood vessel dilation effects by also blocking alpha-1 receptors. All beta blockers are approved for the treatment of hypertension. Other US Food and Drug Administration-approved uses are specific to each beta blocker and include stable and unstable angina, atrial arrhythmias, bleeding esophageal varices, coronary artery disease, asymptomatic and symptomatic heart failure, migraine, and secondary prevention of post-myocardial infarction. The objective of this review was to evaluate the comparative effectiveness and harms of beta blockers in adult patients with hypertension, angina, coronary artery bypass graft, recent myocardial infarction, heart failure, atrial arrhythmia, migraine or bleeding esophageal varices.

Drug Class Reviews - Oregon Health & Science University.

Version: July 2009

Use of Natriuretic Peptide Measurement in the Management of Heart Failure [Internet]

To assess the diagnostic accuracy of B-type natriuretic peptide (BNP) and N-terminal proBNP (NT-proBNP) for detecting heart failure (HF)

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: November 2013

Transitions to palliative care for older people in acute hospitals: a mixed-methods study

Study found that patients with palliative care needs represent a significant proportion of the hospital inpatient population and that there is a significant gap between NHS policy regarding palliative and end-of-life care management in acute hospitals in England and current practice.

Health Services and Delivery Research - NIHR Journals Library.

Version: November 2013
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Effectiveness of Assisted Reproductive Technology

We reviewed the evidence regarding the outcomes of interventions used in ovulation induction, superovulation, and in vitro fertilization (IVF) for the treatment of infertility. Short-term outcomes included pregnancy, live birth, multiple gestation, and complications. Long-term outcomes included pregnancy and post-pregnancy complications for both mothers and infants.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: May 2008

Screening for Cognitive Impairment in Older Adults: An Evidence Update for the U.S. Preventive Services Task Force [Internet]

We conducted this systematic review to support the U.S. Preventive Services Task Force (USPSTF) in updating its recommendation on screening for cognitive impairment in older adults. Our review addresses five questions: 1) Does screening for cognitive impairment in community-dwelling older adults improve decisionmaking, patient, family/caregiver, or societal outcomes?; 2) What is the test performance of screening instruments to detect dementia or mild cognitive impairment (MCI) in community-dwelling older adult primary care patients?; 3) What are the harms of screening for cognitive impairment?; 4) Do interventions for early dementia or MCI in older adults improve decisionmaking, patient, family/caregiver, or societal outcomes?; and 5) What are the harms of interventions for cognitive impairment?

Evidence Syntheses - Agency for Healthcare Research and Quality (US).

Version: November 2013

Drug Class Review: Nonsteroidal Antiinflammatory Drugs (NSAIDs): Final Update 4 Report [Internet]

We compared the effectiveness and harms of oral or topical nonsteroidal antiinflammatory drugs (NSAIDs) in the treatment of chronic pain from osteoarthritis, rheumatoid arthritis, soft tissue pain, back pain, and ankylosing spondylitis.

Drug Class Reviews - Oregon Health & Science University.

Version: November 2010

Enhancing the Use and Quality of Colorectal Cancer Screening

To conduct a systematic review of the use and quality (including underuse, overuse, and misuse) of appropriate colorectal cancer (CRC) screening, including factors associated with screening, effective interventions to improve screening rates, current capacity, and monitoring and tracking the use and quality. Trends in the use and quality of CRC screening tests is also presented.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: February 2010

Clinical trial metadata: defining and extracting metadata on the design, conduct, results and costs of 125 randomised clinical trials funded by the National Institute for Health Research Health Technology Assessment programme

Study found that the ‘metadata’ collected in randomised controlled trial registries can be expanded to include aspects of design, performance, results and costs. Tha National Institute for Health Research Health Technology Assessment programme should continue and expand the work reported.

Health Technology Assessment - NIHR Journals Library.

Version: February 2015

Systematic Reviews in PubMed

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Systematic Review Methods in PubMed

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