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The Agency for Healthcare Research and Quality (AHRQ) is interested in leveraging new collaborative technologies to improve communications within and between various programs within its purview. To investigate some possibilities, the ECRI Institute Evidence-based Practice Center (EPC) was charged with examining the feasibility of using a wiki to support the collaborative development of evidence reports, technical briefs, and systematic reviews by AHRQ's EPCs. A wiki is “a type of Web page designed so that its content can be edited by anyone who accesses it, using a simplified markup language,” according to The Oxford English Dictionary. Wikis could serve multiple purposes in the workflow for EPCs. In addition to serving as a mechanism for reviewing draft reports, wikis could be used in earlier stages of topic refinement and report development, such as in the developmental phases of key questions, inclusion/exclusion criteria, and search strategies. The wiki could serve as a collaborative platform for general methods development and methodology-related discussions and potentially could facilitate submission of topic nominations by partner organizations and public stakeholders.

Methods Research Reports - Agency for Healthcare Research and Quality (US).

Version: September 2011

Study found that there is a need to rethink context and the hierarchical relationships between children, young people, parents and diabetes professionals with regard to ‘partnership and participation’ in diabetes decision-making, self-care and self-management. Additional research, implementation strategies and service redesign are needed to translate – children’s diabetes information resources into optimal self-management knowledge and subsequent optimal diabetes self-management action.

Health Services and Delivery Research - NIHR Journals Library.

Version: March 2014

Health registries greatly enhance health services research, especially when linked with other data sources such as administrative claims. Recently, concerns about patient privacy and data security have produced policies such as the Health Insurance Portability and Accountability Act (HIPAA) that reduce the availability of sensitive identifying information. In this context, the development of effective record linkage approaches for varying scenarios of data availability is critical. This report presents a conceptual framework and instructional information that scientifically describe the strengths and limitations of different approaches to record linkage of registries to other data sources.

Agency for Healthcare Research and Quality (US).

Version: September 2014

This project's goal was to provide a preliminary sketch of the use of text-mining tools as an emerging methodology within a number of systematic review processes. We sought to provide information addressing pressing questions individuals and organizations face when considering utilizing text-mining tools.

Research White Paper - Agency for Healthcare Research and Quality (US).

Version: April 2016

Value of information (VOI) techniques can provide estimates of the expected benefits from clinical research studies. These VOI estimates can inform decisions about the design and priority of those studies. Most VOI studies use decision analytic models to characterize the uncertainty of the effects of interventions on health outcomes. For some potential applications of VOI, the complexity of constructing such models poses barriers to practical application of VOI. However, because some clinical studies can directly characterize uncertainty in health outcomes, it may sometimes be possible to perform VOI analysis with only minimal modeling. This paper (1) develops a framework to define and classify minimal modeling approaches to VOI; (2) reviews existing VOI studies that apply minimal modeling approaches; and (3) illustrates and discusses the application of the minimal modeling to two new clinical applications to which the approach appears well suited because clinical trials with comprehensive outcomes provide preliminary estimates of the uncertainty in outcomes. We conclude that minimal modeling approaches to VOI can be readily applied to in some instances to develop estimates of the expected benefits of clinical research.

Methods Future Research Needs Reports - Agency for Healthcare Research and Quality (US).

Version: June 2011

The study found that there is evidence of some convergence around a small number of high-performing instruments and identification of the components of a high-quality evaluation approach, including AUC analysis; and, furthermore, the upper limits (AUC ≥ 0.85) of instrument-based prediction have probably been achieved and are unlikely to be exceeded using instruments alone

Health Technology Assessment - NIHR Journals Library.

Version: October 2013

As a means to inform clinical and health policy decisions, systematic reviews are inexpensive relative to clinical trials and other (observational) studies but are costly enough that not all possible systematic reviews can be performed. Value of information (VOI) analysis has been considered as a tool to help prioritize topics for systematic review. Since VOI analysis typically involves constructing a complex decision-analytic model of the disease and its treatment to fully characterize the uncertainty in the health outcomes and costs of the treatments or other health interventions being studied, the standard approach to VOI may be prohibitively costly for use in prioritizing systematic reviews. As alternatives to typical full modeling VOI, three newer approaches to analyzing the value of information can be identified that are less burdensome: (1) In a conceptual approach to VOI, information is used about multiplicative elements of VOI, which include comprehensive outcome measures and the implementation and durability of review findings, to provide informative bounds on value of research without formally quantifying this through modeling. (2) In a minimal modeling approach to VOI, which is possible when data on comprehensive outcome measures, such as quality-adjusted life-years or net benefit, are readily available from existing research, VOI can be estimated without constructing a complex model. (3) In a maximal modeling approach to VOI, a single comprehensive model may be constructed to simultaneously inform priorities concerning multiple clinical questions. The presence of these lower cost VOI methods creates the possibility for VOI analysis to be practically applied in priority-setting process for systematic reviews, and raises questions about how the use of VOI can be systematized.

Methods Research Reports - Agency for Healthcare Research and Quality (US).

Version: August 2012

The evidence base which supported the National Institute for Health and Clinical Excellence (NICE) published Clinical Guideline 3 was limited and 50% was graded as amber. However, the use of tests as part of pre-operative work-up remains a low-cost but high-volume activity within the NHS, with substantial resource implications. The objective of this study was to identify, evaluate and synthesise the published evidence on the clinical effectiveness and cost-effectiveness of the routine use of three tests, full blood counts (FBCs), urea and electrolytes tests (U&Es) and pulmonary function tests, in the pre-operative work-up of otherwise healthy patients undergoing minor or intermediate surgery in the NHS.

Health Technology Assessment - NIHR Journals Library.

Version: December 2012

The study found that viscoelastic testing may be effective in reducing the numbers of cardiac surgery patients receiving red blood cell transfusion, platelet transfusion and fresh frozen plasma transfusion, compared with a management strategy based on standard laboratory tests.

Health Technology Assessment - NIHR Journals Library.

Version: July 2015

Systematic Reviews in PubMed

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Systematic Review Methods in PubMed

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