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Immunosuppressive therapy for kidney transplantation in children and adolescents: systematic review and economic evaluation

The study found that tacrolimus maintenance therapy (with azathioprine) and basiliximab induction (with tacrolimus and azathioprine maintenance therapy) were likely to be cost-effective therapies for children and adolescents undergoing renal transplantation. When all immunosuppressive regimens were simultaneously compared using extrapolated adult data, only basiliximab induction therapy with tacrolimus and azathioprine maintenance therapy was cost-effective.

Health Technology Assessment - NIHR Journals Library.

Version: August 2016
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A systematic review of the clinical effectiveness and cost-effectiveness of sensory, psychological and behavioural interventions for managing agitation in older adults with dementia

The study found that supervised person-centred care, communication skills and dementia-care mapping, as well as sensory therapy activities and structured music therapies, reduce agitation in care-home dementia residents. Health and social care costs were between £7000 and £15,000 depending on the severity of agitation. Further work is required to investigate interventions for agitation for use with people with dementia living in their own homes.

Health Technology Assessment - NIHR Journals Library.

Version: June 2014
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Neuraminidase inhibitors for influenza: a systematic review and meta-analysis of regulatory and mortality data

The study found that the neuraminidase inhibitors oseltamivir and zanamivir cause small reductions in the time to first alleviation of influenza symptoms in adults. Oseltamivir increases the risk of nausea, vomiting, psychiatric events in adults and vomiting in children and has no protective effect on mortality among patients with 2009A/H1N1 influenza.

Health Technology Assessment - NIHR Journals Library.

Version: May 2016
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Etanercept, Infliximab and Adalimumab for the Treatment of Psoriatic Arthritis: A Systematic Review and Economic Evaluation

Etanercept, infliximab and adalimumab are licensed in the UK for the treatment of active and progressive psoriatic arthritis (PsA) in adults who have an inadequate response to standard treatment.

Health Technology Assessment - NIHR Journals Library.

Version: February 2011
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Orthotic management of instability of the knee related to neuromuscular and central nervous system disorders: systematic review, qualitative study, survey and costing analysis

The study found limited evidence on the effectiveness of the various types of orthoses used within the NHS to manage patients with neuromuscular and central nervous system conditions, especially in relation to the outcomes that are important to patients.

Health Technology Assessment - NIHR Journals Library.

Version: July 2016
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Systematic Reviews in PubMed

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