Home > Search Results

Results: 15

Prostate Cancer: Diagnosis and Treatment

The original Prostate Cancer: Diagnosis and Treatment Guideline published in 2008 was the first clinical guideline produced by the National Collaborating Centre for Cancer (NCC-C); accordingly this is now the first NCC-C clinical guideline to be reviewed and updated. Many areas of the original guideline are unchanged as there is little or no new evidence; other aspects have been completely rewritten. As ever there are still many topics where the research evidence is incomplete or conflicting, and so the Guideline Development Group (GDG) have been required to reach a consensus using the evidence available to them in several areas. In places where it was clear that further work needed to be done, new research recommendations have been made which we hope will be used as the basis for future research work.

NICE Clinical Guidelines - National Collaborating Centre for Cancer (UK).

Version: January 2014
Show search results within this document

Non‐surgical interventions for late rectal consequences of radiotherapy in people who have received radical radiotherapy to the pelvis

Radiotherapy is often used to treat cancer in the pelvic area. Several organs in the pelvis, such as the anus, rectum, bladder, prostate, gynaecological organs (womb, ovaries, cervix, and vagina), small bowel, and pelvic bones may be exposed to the effects of radiotherapy, which can lead to pelvic radiation disease. Symptoms from pelvic radiation disease may occur around the time of treatment (early effects) or over a period of time, often many years after treatment (late effects) due to long‐term changes secondary to scarring (fibrosis), narrowing (stenosis), and bleeding due to new blood vessel formation (telangiectasia). Damage to the rectum (radiation proctopathy) is the most often investigated late radiation effect to the pelvis, which affects a small but but still important group of people who undergo pelvic radiotherapy. The common symptoms are rectal urgency, rectal incontinence, pain, mucus discharge, and rectal bleeding.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2016

Faecal calprotectin testing for differentiating amongst inflammatory and non-inflammatory bowel diseases: systematic review and economic evaluation

Study finds that faecal calprotectin can be a highly sensitive way of detecting inflammatory bowel disease (IBD); in most cases, a negative calprotectin test result rules out IBD, thereby sparing most people with irritable bowel syndrome from having to undergo invasive investigations, such as colonoscopy.

Health Technology Assessment - NIHR Journals Library.

Version: November 2013
Show search results within this document

Nocturnal Enuresis: The Management of Bedwetting in Children and Young People

This guideline aims to provide advice on the assessment and management of children and young people with bedwetting. The guidance is applicable to children and young people up to 19 years with the symptom of bedwetting. It has been common practice to define enuresis as abnormal from 5 years and only to consider children for treatment when they are 7 years. While the prevalence of symptoms decreases with age the guideline scope did not specify a younger age limit in order to consider whether there were useful interventions that might be of benefit to children previously excluded from advice and services.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: 2010
Show search results within this document

Stereotactic Body Radiation Therapy [Internet]

Conduct a systematic literature scan for published data for the treatment of stereotactic body radiation therapy (SBRT) and provide a broad overview of the current state of SBRT for solid malignant tumors.

Comparative Effectiveness Technical Briefs - Agency for Healthcare Research and Quality (US).

Version: May 2011
Show search results within this document

Colorectal Cancer: The Diagnosis and Management of Colorectal Cancer

This guideline is relevant to all healthcare professionals who come into contact with patients with colorectal cancer or suspected of having colorectal cancer, as well as to the patients themselves and their carers. It is also expected that the guideline will be of value to those involved in clinical governance in both primary and secondary care to help ensure that arrangements are in place to deliver appropriate care for the population covered by this guideline.

NICE Clinical Guidelines - National Collaborating Centre for Cancer (UK).

Version: November 2011
Show search results within this document

Safety of Probiotics to Reduce Risk and Prevent or Treat Disease

To catalog what is known about the safety of interventions containing Lactobacillus, Bifidobacterium, Saccharomyces, Streptococcus, Enterococcus, and/or Bacillus strains used as probiotic agents in research to reduce the risk of, prevent, or treat disease.

Evidence Reports/Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: April 2011
Show search results within this document

Ulcerative Colitis: Management in Adults, Children and Young People [Internet]

Ulcerative colitis is the most common type of inflammatory disease of the bowel. It has an incidence in the UK of approximately 10 per 100,000 people annually,and a prevalence of approximately 240 per 100,000. This amounts to around 146,000 people in the UK with a diagnosis of ulcerative colitis. The cause of ulcerative colitis is unknown. It can develop at any age, but peak incidence is between the ages of 15 and 25 years, with a second, smaller peak between 55 and 65 years (although this second peak has not been universally demonstrated). The British Paediatric Surveillance Unit reported an incidence of ulcerative colitis in children aged younger than 16 years in the United Kingdom, of 1.4 per 100,000 with a greater proportion of Asian children having ulcerative colitis than other children. The median age for diagnosis of ulcerative colitis overall in this childhood cohort was 11.7 years (range 9.3 to 13.7 years).

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: June 2013
Show search results within this document

The Value of FDG Positron Emission Tomography/Computerised Tomography (PET/CT) in Pre-Operative Staging of Colorectal Cancer: A Systematic Review and Economic Evaluation

In the UK, colorectal cancer (CRC) is the third most common malignancy (behind lung and breast cancer) with 37,514 cases registered in 2006: around two-thirds (23,384) in the colon and one-third (14,130) in the rectum. Treatment of cancers of the colon can vary considerably, but surgical resection is the mainstay of treatment for curative intent. Following surgical resection, there is a comprehensive assessment of the tumour, it's invasion characteristics and spread (tumour staging). A number of imaging modalities are used in the pre-operative staging of CRCs including; computerised tomography (CT), magnetic resonance imaging, ultrasound imaging and positron emission tomography (PET). This report examines the role of CT in combination with PET scanning (PET/CT ‘hybrid’ scan). The research objectives are: to evaluate the diagnostic accuracy and therapeutic impact of fluorine-18-deoxyglucose (FDG) PET/CT for the pre-operative staging of primary, recurrent and metastatic cancer using systematic review methods; undertake probabilistic decision-analytic modelling (using Monte Carlo simulation); and conduct a value of information analysis to help inform whether or not there is potential worth in undertaking further research.

Health Technology Assessment - NIHR Journals Library.

Version: September 2011
Show search results within this document

Irritable Bowel Syndrome in Adults: Diagnosis and Management of Irritable Bowel Syndrome in Primary Care [Internet]

This guideline covers areas relevant to the diagnosis and management of irritable bowel syndrome (IBS) reflecting the complete patient journey, from the person presenting with IBS symptoms, positive diagnosis and management, targeted at symptom control. The guideline incorporates Cochrane reviews, published NICE clinical and public health guidance, Health Technology Assessment reports, systematic and health economic reviews produced by the National Collaborating Centre for Nursing and Supportive Care. Recommendations are based on clinical and cost effectiveness evidence, and where this is insufficient, the GDG used all available information sources and experience to make consensus recommendations using nominal group technique.

NICE Clinical Guidelines - National Collaborating Centre for Nursing and Supportive Care (UK).

Version: February 2008
Show search results within this document

Gastrointestinal Complications (PDQ®): Health Professional Version

Expert-reviewed information summary about constipation, impaction, bowel obstruction, and diarrhea as complications of cancer or its treatment. The management of these problems is discussed.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: September 9, 2016

Diagnosis of Right Lower Quadrant Pain and Suspected Acute Appendicitis [Internet]

The reliable identification of patients with abdominal pain who need surgical intervention for acute appendicitis can improve clinical outcomes and reduce resource use. The test performance and impact on outcomes of alternative diagnostic strategies are unclear.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: December 2015
Show search results within this document

Lomitapide (Juxtapid) [Internet]

The objective of this review is to evaluate the beneficial and harmful effects of lomitapide added to other lipid-lowering therapy in patients with homozygous familial hypercholesterolemia (HoFH).

Common Drug Review - Canadian Agency for Drugs and Technologies in Health.

Version: July 2015
Show search results within this document

Suspected Cancer: Recognition and Referral

Cancer is an important condition, both in terms of the number of people affected and the impacts on those people and the people close to them. Around one third of a million new cancers are diagnosed annually in the UK, across over 200 different cancer types. Each of these cancer types has different presenting features, though there may be overlap. More than one third of the population will develop a cancer in their lifetime. Although there have been large advances in treatment and survival, with a half of cancer sufferers now living at least ten years after diagnosis, it remains the case that more than a quarter of all people alive now will die of cancer.

NICE Guideline - National Collaborating Centre for Cancer (UK).

Version: June 2015
Show search results within this document

Therapy for treatment and prevention of pouchitis

Some patients with ulcerative colitis have their colon and rectum removed with construction of a pouch (made from a loop of small intestine) to serve in place of the rectum. This is known as ileal pouch‐anal anastomosis (IPAA) surgery. Pouchitis is inflammation of the surgically constructed pouch. Symptoms of active pouchitis include diarrhea, increased stool frequency, abdominal cramping, fecal urgency, tenesmus (feeling of constantly needing to pass stools), and incontinence. Periods when symptoms stop are called 'remission'.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2015

Systematic Reviews in PubMed

See all (4)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...