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A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome

Study found that reflex testing for Lynch syndrome in newly diagnosed colorectal cancer patients aged under 50 years is cost-effective, and that such testing may also be cost-effective in newly diagnosed patients aged under 60 or under 70 years. However, the results are subject to uncertainty due to a number of parameters.

Health Technology Assessment - NIHR Journals Library.

Version: September 2014
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Familial Breast Cancer: Classification and Care of People at Risk of Familial Breast Cancer and Management of Breast Cancer and Related Risks in People with a Family History of Breast Cancer

This guidance updates and replaces NICE clinical guideline 14 (published May 2004) and NICE clinical guideline 41 (published July 2006).

NICE Clinical Guidelines - National Collaborating Centre for Cancer (UK).

Version: June 2013
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Genetics of Colorectal Cancer (PDQ®): Health Professional Version

Expert-reviewed information summary about the genetics of colorectal cancer, including information about specific genes and family cancer syndromes. The summary also contains information about screening for colorectal cancer and research aimed at prevention of this disease. Psychosocial issues associated with genetic testing and counseling of individuals who may have hereditary colorectal cancer syndrome are also discussed.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: December 1, 2016

Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of unusual cancers of childhood such as cancers of the head and neck, chest, abdomen, reproductive system, skin, and others.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: November 30, 2016

Unusual Cancers of Childhood Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of unusual cancers of childhood such as cancers of the head and neck, chest, abdomen, reproductive system, skin, and others.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: December 1, 2016

Genetics of Breast and Gynecologic Cancers (PDQ®): Health Professional Version

Expert-reviewed information summary about the genetics of breast and gynecologic cancers, including information about specific genes and family cancer syndromes. The summary also contains information about interventions that may influence the risk of developing breast and gynecologic cancers in individuals who may be genetically susceptible to these diseases. Psychosocial issues associated with genetic testing are also discussed.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: December 1, 2016

Update on Emerging Genetic Tests Currently Available for Clinical Use in Common Cancers [Internet]

The Coverage and Analysis Group at the Centers for Medicare and Medicaid Services (CMS) requested that the Technology Assessment Program (TAP) of the Agency for Healthcare Research and Quality (AHRQ) conduct an update of genetic tests for cancer conditions that were identified since the 2011 horizon scan report on Genetic Testing for Cancer. AHRQ assigned this project to the Tufts Medical Center Evidence-based Practice Center (Contract Number: HHSA 290 2007 10055 I, Task Order #11).

Technology Assessment Report - Agency for Healthcare Research and Quality (US).

Version: July 19, 2013
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Pancreatic Cancer Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of pancreatic cancer.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: June 30, 2016

Cancer Genetics Overview (PDQ®): Health Professional Version

Expert-reviewed information summary in which the features of hereditary cancer and the structure and content of other PDQ cancer genetics summaries are described. The summary also contains an extensive list of genetics resources available online.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: November 18, 2016

Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version

Expert-reviewed information summary in which cancer risk perception, risk communication, and risk counseling are discussed. The summary also contains information about recording and analyzing a family history of cancer and factors to consider when offering genetic testing.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: November 22, 2016

Late Effects of Treatment for Childhood Cancer (PDQ®): Health Professional Version

Expert-reviewed information summary about the health problems that continue or appear after cancer treatment has ended.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: October 21, 2016

Rectal Cancer Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of rectal cancer.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: August 12, 2016

Aspirin Use for the Prevention of Colorectal Cancer: An Updated Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet]

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women in the United States (U.S.). Aspirin may inhibit CRC development and related mortality.

Evidence Syntheses - Agency for Healthcare Research and Quality (US).

Version: September 2015
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Surveillance for hereditary cancer: does the benefit outweigh the psychological burden? A systematic review

Individuals at risk for developing hereditary cancer are offered surveillance in order to improve the prognosis. An important question is whether the benefit of surveillance outweighs the psychological burden. In this review, we evaluated all studies that investigated psychological distress and the quality of life in individuals under surveillance for hereditary cancer of the breast, ovarian, prostate, pancreas, colorectum, melanoma, and various rare syndromes such as familial adenomatous polyposis, Li-Fraumeni and Peutz-Jeghers syndrome. Thirty-two studies were identified. Surveillance for most hereditary cancers was associated with good psychological outcomes. However, surveillance of individuals at high risk for developing multiple tumors appeared to be associated with increased distress and a lower quality of life. Common factors associated with worse psychological outcomes included a personal history of cancer, female gender, having a first degree relative with cancer, negative illness perceptions and coping style. The use of a simple screening tool to identify distressed individuals is recommended.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

Systematic Reviews in PubMed

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