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As a result of the introduction of chemotherapy, the survival of children with osteosarcoma has improved dramatically. The majority of the currently used treatment protocols are based on a combination of doxorubicin, cisplatin, methotrexate (MTX) and/or ifosfamide, of which MTX seems to be one of the most active drugs. However, in the literature, this has not been unambiguously proven. A well‐informed decision on the use of MTX in the treatment of children and young adults diagnosed with primary high‐grade osteosarcoma should be based on high quality evidence on both antitumour effects and adverse effects.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: May 11, 2011

Expert-reviewed information summary about the treatment of osteosarcoma/malignant fibrous histiocytoma of bone.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 5, 2018

We reviewed the evidence of the effectiveness of any medical intervention to prevent hearing loss in children with cancer treated with platinum‐based therapy (that is, including the anti‐cancer drugs cisplatin, carboplatin, oxaliplatin, or a combination of these). We also looked at anti‐cancer effectiveness, side effects other than hearing loss and quality of life.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: September 27, 2016

Cancer-related post-traumatic stress can occur any time from diagnosis to after treatment ends. Shock, fear, helplessness, or horror can be felt by cancer patients and lead to cancer-related post-traumatic stress. Learn about the causes and ways doctors can help manage these symptoms of distress in this expert-reviewed summary.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: July 7, 2015

Expert-reviewed information summary about the treatment of lymphedema, a condition in which lymph fluid builds up in tissues and causes swelling.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: May 29, 2015

Expert-reviewed report about grief, bereavement, and feelings of loss in survivors of someone who has died of cancer. Grief in children is also discussed.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: March 6, 2013

Late effects of cancer treatment can cause serious, disabling, and life-threatening chronic health conditions that adversely affect the health of aging childhood cancer survivors. Learn about subsequent neoplasms and the cardiovascular, cognitive, psychosocial, digestive, endocrine, immune, musculoskeletal, reproductive, and urinary late effects of pediatric cancer treatment in this expert-reviewed summary.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 2, 2018

The treatment of cancer may cause health problems (late effects) for childhood cancer survivors months or years after successful treatment has ended. Get information about the long-term physical, psychological and social effects of treatment for childhood cancer in this expert-reviewed summary.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: November 21, 2017

Expert-reviewed information summary about the treatment of childhood soft tissue sarcomas.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: April 9, 2018

Expert-reviewed information summary about the treatment of retinoblastoma in children.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 29, 2018

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