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Nitazoxanide for chronic hepatitis C

Hepatitis C is a virus that infects people’s liver. When an infection goes on for a long time, it is said to be ‘chronic’.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2014

Not enough evidence on effectiveness of drugs or preventive measures on disease caused by Cryptosporidium.

Cryptosporidiosis is a disease that causes diarrhoea, and can be life‐threatening in individuals whose bodies are not able to resist infections. It causes disease in the both the developed and the developing world. This review of trials found insufficient evidence to say whether any drug is able to reduce or cure the symptoms of Cryptosporidium infection or to effectively kill the organism among individuals who cannot resist infections. A limited amount of evidence was found indicating that the drug nitaxozanide can kill the organism in individuals with a normal immunity.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Drugs for treating giardiasis

Giardiasis is an infection of the small intestine caused by a microscopic organism called Giardia lamblia. The infection is passed from person to person by ingesting faecally contaminated water or food. Symptoms frequently include diarrhoea, abdominal pain, flatulence, bloating, vomiting, and weight loss. In this review, we assess alternatives to the most commonly used treatment for giardiasis; metronidazole given orally for five or more days.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Antibiotic therapy for Clostridium difficile‐associated diarrhoea in adults

Clostridium difficile (C. difficile) is a bacterium that can live harmlessly in the colon, but when an individual takes an antibiotic for another condition, the C. difficile can grow and replace most of the normal bacterial flora that live in the colon. This overgrowth causes C. difficile‐associated diarrhoea (also known as C. difficile infection ‐ CDI). The symptoms of CDI include diarrhoea, fever and pain. CDI may be only mild but in many cases is very serious and, if untreated, can be fatal. There are many proposed treatments for CDI, but the most common are withdrawing the antibiotic that caused the CDI and prescribing an antibiotic that kills the bacterium. Many antibiotics have been tested in clinical trials for effectiveness and this review studies the comparisons of these antibiotics. This review is an update of a previously published Cochrane review.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2017

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