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Speech recognition in the radiology department: a systematic review

Bibliographic details: Hammana I, Lepanto L, Poder T, Bellemare C, Ly MS.  Speech recognition in the radiology department: a systematic review. Health Information Management Journal 2014: epub25425535

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Safety, Effectiveness, and Cost-Effectiveness of New Oral Anticoagulants Compared with Warfarin in Preventing Stroke and Other Cardiovascular Events in Patients with Atrial Fibrillation [Internet]

Approximately 250,000 Canadians are affected by atrial fibrillation (AF). Stroke is a complication of AF, and Canadians with AF are five times more likely to have a stroke and are twice as likely to die than individuals without AF. AF and stroke are more common among the elderly.

CADTH Therapeutic Review - Canadian Agency for Drugs and Technologies in Health.

Version: April 9, 2012
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Radiotherapy combined with surgical treatment for gastric cancer: a meta analysis

Bibliographic details: Guo LY, Ma B, Yang KH, Wang XH.  Radiotherapy combined with surgical treatment for gastric cancer: a meta analysis. Tumor 2010; 30(4): 303-309

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Antithrombotic Agents for the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation [Internet]

Atrial fibrillation (AF) is a common cardiac arrhythmia associated with increased morbidity and mortality. Patients with AF are at increased risk of systemic embolism (SE) and stroke, which can cause death, disability, and impaired quality of life. Antithrombotic therapies, such as oral anticoagulant and antiplatelet drugs, can reduce the risk for stroke and systemic thromboembolism and are recommended for most AF patients with risk factors for stroke. Antithrombotic therapies are also associated with a risk of bleeding, and their efficacy for stroke prevention should always be balanced against a patient’s risk of hemorrhage.

CADTH Therapeutic Review - Canadian Agency for Drugs and Technologies in Health.

Version: March 2013
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A systematic review and economic evaluation of diagnostic strategies for Lynch syndrome

Study found that reflex testing for Lynch syndrome in newly diagnosed colorectal cancer patients aged under 50 years is cost-effective, and that such testing may also be cost-effective in newly diagnosed patients aged under 60 or under 70 years. However, the results are subject to uncertainty due to a number of parameters.

Health Technology Assessment - NIHR Journals Library.

Version: September 2014
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Pregabalin monotherapy for epilepsy

A number of people continue to have seizures and many experience adverse effects, despite current antiepileptic treatments. As a result, there is increasing interest in new pharmacological treatment options such as pregabalin. This systematic review evaluated the efficacy and tolerability of pregabalin in people with epilepsy. The review authors only included two, short‐term randomised controlled trials involving 753 participants treated with pregabalin monotherapy for epilepsy. Studies included in this review suggested that pregabalin was inferior to lamotrigine but was better than gabapentin, but we found some limitations in the study design which may have had a great influence on the results. There is no strong evidence to support its monotherapy as a treatment for epilepsy. Long‐term trials and high quality randomised clinical trials are needed to evaluate the efficacy and safety of pregabalin monotherapy for treating epilepsy.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2012

Recommendations for Antithrombotic Agents for the Prevention of Stroke and Systemic Embolism in Patients With Atrial Fibrillation [Internet]

Atrial fibrillation (AF) is a common cardiac arrhythmia associated with increased morbidity and mortality. Patients with AF are at risk of stroke and systemic embolism (SSE), which can cause death, disability, and impaired quality of life. Antithrombotic therapies, such as oral anticoagulant and antiplatelet drugs, can reduce the risk for stroke and systemic thromboembolism and are recommended for most AF patients with risk factors for stroke. The risk of stroke varies considerably across patients; therefore, major guidelines recommend antithrombotic therapy based on risk assessment, quantified using a validated tool such as the CHADS2 score.

Canadian Agency for Drugs and Technologies in Health.

Version: March 2013
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Integrated sensor-augmented pump therapy systems [the MiniMed® Paradigm™ Veo system and the Vibe™ and G4® PLATINUM CGM (continuous glucose monitoring) system] for managing blood glucose levels in type 1 diabetes: a systematic review and economic evaluation

The study found evidence to suggest that integrated continuous glucose monitoring insulin pump therapy systems are more clinically effective in patients with type 1 diabetes than stand-alone treatments. However, based on the evidence available, these integrated systems are unlikely to be cost-effective in comparison with stand-alone insulin delivery and monitoring. Further research on the clinical effectiveness and cost-effectiveness of these integrated systems in different populations is warranted.

Health Technology Assessment - NIHR Journals Library.

Version: February 2016
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Octaplas Compared with Fresh Frozen Plasma to Reduce the Risk of Transmitting Lipid-Enveloped Viruses: An Economic Analysis and Budget Impact Analysis [Internet]

Health Canada recently licensed Octaplas, which can now be considered as an alternative to standard fresh frozen plasma (FFP) for certain indications. Since, on average, 200,000 units of FFP are transfused annually in Canada, the widespread implementation of Octaplas may have significant public health and economic implications. This study investigates the cost-effectiveness position of Octaplas against standard FFP and its budgetary impact to the health care system.

CADTH Technology Report - Canadian Agency for Drugs and Technologies in Health.

Version: March 2011
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Sofosbuvir (Sovaldi): Sofosbuvir is Indicated for the Treatment of Chronic Hepatitis C Virus (CHC) Infection in Adult Patients With Compensated Liver Disease, Including Cirrhosis [Internet]

Objective: To perform a systematic review of the beneficial and harmful effects of sofosbuvir in combination with other agents for the treatment of adults with chronic hepatitis C virus (CHC) infection (genotypes 1, 2, 3, or 4).

Common Drug Review - Canadian Agency for Drugs and Technologies in Health.

Version: October 2014
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Oral anticoagulants for primary prevention, treatment and secondary prevention of venous thromboembolic disease, and for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis and cost-effectiveness analysis

The study found that the use of novel oral anticoagulants has advantages over warfarin in patients with atrial fibrillation, but there was no strong evidence that they should replace warfarin or low-molecular-weight heparin in the primary prevention, treatment or secondary prevention of venous thromboembolic disease.

Health Technology Assessment - NIHR Journals Library.

Version: March 2017
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The diagnostic accuracy and cost-effectiveness of magnetic resonance spectroscopy and enhanced magnetic resonance imaging techniques in aiding the localisation of prostate abnormalities for biopsy: a systematic review and economic evaluation

Study assessing the diagnostic accuracy of magnetic resonance spectroscopy (MRS) and enhanced magnetic resonance imaging (MRI) techniques in aiding the localisation of prostate abnormalities for biopsy found that MRS had higher sensitivity and specificity than T2-weighted magnetic resonance imaging (T2-MRI) but produced no definitive conclusions on the cost-effectiveness of using different MRS/MRI sequences.

Health Technology Assessment - NIHR Journals Library.

Version: May 2013
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New Oral Anticoagulants for the Prevention of Thromboembolic Events in Patients with Atrial Fibrillation: Recommendations [Internet]

Atrial fibrillation (AF), the most common cardiac rhythm abnormality, is associated with substantial morbidity. AF-related mortality is mainly attributable to complications of stroke. Stroke risk can be quantified using a validated tool such as the CHADS2 score. Warfarin, a vitamin K antagonist, is the standard of care for patients with AF and has demonstrated efficacy in the prevention of stroke. Warfarin has a narrow therapeutic window, produces varied responses among patients, and interacts with some types of food and other drugs, all of which necessitates routine laboratory monitoring.

CADTH Therapeutic Review - Canadian Agency for Drugs and Technologies in Health.

Version: June 2012
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Comparative Effectiveness of Warfarin and Newer Oral Anticoagulants for the Long-Term Prevention and Treatment of Arterial and Venous Thromboembolism [Internet]

The Veterans Health Administration (VHA) System serves a largely older, male population with a high prevalence of chronic atrial fibrillation (AF) and venous thromboembolism (VTE). Many veterans with chronic AF have risk profiles for stroke that, according to current clinical guidelines, place them in a risk group where chronic anticoagulation is recommended. Adjusted-dose warfarin has been the preferred approach to chronic anticoagulation in the VHA, and in many VHA settings, specialized therapeutic drug-monitoring services provide high-quality warfarin treatment. However, the advent of newer anticoagulants with the promise of simplified long-term anticoagulation requires reconsideration of current treatment practices. The purpose of this systematic review was to study the comparative effectiveness of warfarin and the newer oral anticoagulants used for the long-term prevention and treatment of arterial and venous thromboembolism. An evaluation of newer oral anticoagulants for VTE prophylaxis in the perioperative period will be the subject of a later report.

Evidence-Based Synthesis Program - Department of Veterans Affairs (US).

Version: April 2012
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Ivacaftor for the treatment of patients with cystic fibrosis and the G551D mutation: a systematic review and cost-effectiveness analysis

Study found that ivacaftor is a clinically effective treatment for patients with cystic fibrosis and the G551D mutation; however, the high cost of ivacaftor may be a barrier to its uptake. Ivacaftor resulted in significant improvements compared with placebo for all but one of the subgroups investigated; further research should prioritise investigating its long-term effectiveness.

Health Technology Assessment - NIHR Journals Library.

Version: March 2014
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Using clinical practice variations as a method for commissioners and clinicians to identify and prioritise opportunities for disinvestment in health care: a cross-sectional study, systematic reviews and qualitative study

This study found large variability in the use of some common procedures that cannot be explained by differences in local need and may reflect uncertainty about appropriate use. This may help identify procedures that could be reassessed for disinvestment.

Health Services and Delivery Research - NIHR Journals Library.

Version: April 2015
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Monitoring for Atrial Fibrillation in Discharged Stroke and Transient Ischemic Attack Patients: A Clinical and Cost-Effectiveness Analysis and Review of Patient Preferences [Internet]

In-patient cardiac monitoring following a stroke or transient ischemic attack (TIA) captures only a fraction of occult atrial fibrillation (AF) cases, and substantial evidence suggests that the detection rate increases with prolonged monitoring time. To inform decision-makers about the appropriate use of outpatient cardiac monitoring devices in patients who have experienced a stroke or TIA, CADTH conducted a health technology assessment (HTA) on the clinical effectiveness and cost-effectiveness of cardiac monitoring devices in outpatient stroke or TIA patients. Patient perspectives and experiences regarding the value and impact of outpatient AF cardiac monitoring devices were also considered.

CADTH Optimal Use Report - Canadian Agency for Drugs and Technologies in Health.

Version: March 2016
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Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer: A Decision Analysis: Technical Report [Internet]

Evidence indicates that aspirin is effective for the primary prevention of cardiovascular disease (CVD) and colorectal cancer (CRC), but regular use also increases risk for gastrointestinal (GI) and cerebral hemorrhages.

Evidence Syntheses - Agency for Healthcare Research and Quality (US).

Version: September 2015
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Somatropin (Genotropin) for Subcutaneous Injection: Long-term Treatment of Children who have Growth Failure Due to an Inadequate Secretion of Endogenous Growth Hormone [Internet]

The objective of this systematic review is to compare the benefits and harms of Genotropin with other available somatropin products in children with growth hormone deficiency (GHD).

Common Drug Review - Canadian Agency for Drugs and Technologies in Health.

Version: January 2014
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KRAS mutation testing of tumours in adults with metastatic colorectal cancer: a systematic review and cost-effectiveness analysis

Study found that there was no strong evidence that any one KRAS mutation test was more effective or cost-effective than any other test for differentiating adults with metastatic colorectal cancer whose metastases are confined to the liver and are unresectable and who may benefit from first-line treatment with cetuximab in combination with standard chemotherapy from those who should receive standard chemotherapy alone.

Health Technology Assessment - NIHR Journals Library.

Version: October 2014
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