Home > Search Results

The septum is a wall of tissue which separates the left heart from the right heart. Defects allow blood to flow from the right side of the heart to the left, reducing the heart's efficiency.

Results: 1 to 20 of 49

Atrial septal defect closure is associated with a reduced prevalence of atrial tachyarrhythmia in the short to medium term: a systematic review and meta-analysis

Atrial tachyarrhythmias are a common complication of atrial septal defects. The objective was to determine the effect of atrial septal defect closure on pre-existing atrial tachyarrhythmias and to investigate if such an effect is present after either surgical or percutaneous closure. Medline, EMBASE, Cochrane Library, and Google Scholar databases were searched between 1967 and 2009. The search was expanded using the 'related articles' function and reference lists of key studies. All studies reporting pre- and post- closure incidence (or prevalence) of atrial tachyarrhythmias in the same patient groups were included. Data were independently extracted by two authors according to a pre-defined protocol. Incongruities were settled by consensus decision. Twenty six studies were identified including 1841 patients who underwent surgical closure and 945 who underwent percutaneous closure. Meta-analysis using a random effects model demonstrated a reduction in the prevalence of atrial tachyarrhythmias following atrial septal defect closure [OR = 0.66 (95% CI 0.57-0.77)]. This effect was demonstrated after both percutaneous [OR = 0.49 (95% CI 0.32-0.76)] and surgical closure [OR = 0.72 (95% CI 0.60-0.87)]. Immediate (<30 days) and mid-term (30 days - 5 years) follow-up also demonstrated a reduction in AT prevalence [ORs of 0.80 (95% CI 0.66-0.97) and 0.47 (95% CI 0.36-0.62) respectively]. Atrial septal defect closure, whether surgical or percutaneous, is associated with a reduction in the post-closure prevalence of pre-existing atrial tachyarrhythmias and atrial fibrillation in the short to medium term.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2010

Newborn screening for congenital heart defects: a systematic review and cost-effectiveness analysis

The objectives of this study were to provide evidence to inform policy decisions about the most appropriate newborn screening strategy for congenital heart defects and to identify priorities for future research that might reduce important uncertainties in the evidence base for such decisions.

NIHR Health Technology Assessment programme: Executive Summaries - NIHR Journals Library.

Version: 2005

Totally endoscopic atrial septal repair with or without robotic assistance: a systematic review and meta-analysis of case series

OBJECTIVE: To evaluate the safety and efficacy of totally endoscopic repair of atrial septal defect (ASD).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

A systematic review and economic evaluation of new-generation computed tomography scanners for imaging in coronary artery disease and congenital heart disease: Somatom Definition Flash, Aquilion ONE, Brilliance iCT and Discovery CT750 HD

Report finds that new-generation computed tomography (NGCCT) may be sufficiently accurate to diagnose clinically significant coronary artery disease (CAD) in some, or all, difficult-to-image patient groups and may be particularly useful in ruling out patients from further invasive investigations. Economic analyses suggest that NGCCT is likely to be considered cost-effective for difficult-to-image patients with CAD, at current levels of willingness to pay in the NHS. For patients with suspected CAD, the NGCCT-only strategy may be most favourable; for patients with known CAD, NGCCT along with invasive coronary angiography may be most favourable.

Health Technology Assessment - NIHR Journals Library.

Version: March 2013
Show search results within this document

Implantable cardioverter defibrillators for the treatment of arrhythmias and cardiac resynchronisation therapy for the treatment of heart failure: systematic review and economic evaluation

Study found that implantable cardiac defibrillators reduced all-cause mortality in people at increased risk of sudden cardiac death as a result of previous ventricular arrhythmias or cardiac arrest, remote myocardial infarction or ischaemic/non-ischaemic heart failure and LVEF ≤ 35%. Cardiac resynchronisation therapy reduced all-cause mortality and improved other outcomes in people with heart failure as a result of left ventricular systolic dysfunction and cardiac dyssynchrony when compared with optimal pharmacological therapy. The devices were cost-effective at a willingness-to-pay threshold of £30,000 when compared with optimal pharmacological therapy.

Health Technology Assessment - NIHR Journals Library.

Version: August 2014

Identification and Management of Familial Hypercholesterolaemia (FH) [Internet]

While the NHS in England and Wales has made spectacular progress in improving the secondary prevention of cardiovascular disease, we now need to work harder to identify those who are at particularly high risk of myocardial infarction.

NICE Clinical Guidelines - National Collaborating Centre for Primary Care (UK).

Version: August 2008
Show search results within this document

What evidence is there for a relationship between organisational features and patient outcomes in congenital heart disease services? A rapid review

This rapid review found that while a relationship between volume of cases and patient outcome in congenital heart disease services exists, it is not consistent. In addition, a range of other factors were found that influenced outcome including condition severity, individual centre and surgeon effects and clinical advances over time.

Health Services and Delivery Research - NIHR Journals Library.

Version: November 2014
Show search results within this document

PFO closure vs medical therapy in cryptogenic stroke or transient ischemic attack: a systematic review and meta-analysis

BACKGROUND/OBJECTIVES: This study aims to assess whether patent foramen ovale (PFO) closure is superior to medical therapy in preventing recurrence of cryptogenic ischemic stroke or transient ischemic attack (TIA).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Amplatzer transcatheter and surgical closure for ostium secundum atrial septal defects: a systematic review

Bibliographic details: Tang C, Zeng Z, Li J, Cao W Z, Huang P.  Amplatzer transcatheter and surgical closure for ostium secundum atrial septal defects: a systematic review. Chinese Journal of Evidence-Based Medicine 2007; 7(4): 267-275

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Amplatzer PFO occluder device may prevent recurrent stroke in patients with patent foramen ovale and cryptogenic stroke: a meta-analysis of randomised trials

OBJECTIVE: To review efficacy of percutaneous closure of patent foramen ovale compared with medical therapy in prevention of recurrent strokes in patients with cryptogenic stroke.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2014

Percutaneous versus surgical closure of secundum atrial septal defects: a systematic review and meta-analysis of currently available clinical evidence

AIMS: To summarise data from studies comparing surgical (SC) versus percutaneous closure (PC) of atrial septal defects (ASDs).

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2011

Amplatzer occluder versus CardioSEAL/STARFlex occluder: a meta-analysis of the efficacy and safety of transcatheter occlusion for patent foramen ovale and atrial septal defect

OBJECTIVE: Percutaneous transcatheter occlusion has benefited thousands of patients suffering from patent foramen ovale and atrial septal defect. However, no general agreement has been reached on the superiority among occluders. Thus, a meta-analysis between the two most commonly adopted types of occluders was conducted.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Drugs for Pulmonary Arterial Hypertension: Comparative Efficacy, Safety, and Cost-Effectiveness [Internet]

The objective of this therapeutic review is to conduct a systematic review to assess the comparative efficacy and safety and to determine the cost-effectiveness of drug therapies for the treatment of pulmonary arterial hypertension (PAH) in adults.

CADTH Therapeutic Review - Canadian Agency for Drugs and Technologies in Health.

Version: March 2015
Show search results within this document

Routine echocardiography in the management of stroke and transient ischaemic attack: a systematic review and economic evaluation

Study found that, transthoracic echocardiography in second harmonic imaging mode is a cost-effective use of NHS resources in those cases where clinicians deem it the most appropriate method of testing to identify cardiac sources of stroke and transient ischaemic attack. However, the study highlights that there is a lack of evidence in several areas and the results of the economic evaluation should be treated with caution.

Health Technology Assessment - NIHR Journals Library.

Version: March 2014
Show search results within this document

Robot-Assisted Surgery Compared with Open Surgery and Laparoscopic Surgery: Clinical Effectiveness and Economic Analyses [Internet]

The primary objectives of this Health Technology Assessment (HTA) were to assess the clinical and cost-effectiveness of robotic surgery compared with open procedures and laparoscopic procedures. We conducted a systematic review to evaluate the clinical effectiveness of robotic surgery compared with open procedures and laparoscopic procedures, followed by a systematic review of economic evaluation studies. We also conducted a primary economic evaluation of robotic surgery in one indication from a Canadian perspective and assessed robotic surgery’s potential impact on health services (population impact and budget impact) in Canada.

CADTH Technology Report - Canadian Agency for Drugs and Technologies in Health.

Version: September 2011
Show search results within this document

Transcatheter closure versus medical therapy of patent foramen ovale and presumed paradoxical thromboemboli

This review assessed transcatheter closure and medical therapy for patent foramen ovale. The authors concluded that transcatheter closure may prevent a substantial number of recurrent strokes, but definitive conclusions were not possible because of methodological limitations and a lack of comparability between the studies of these treatments. The authors' cautious conclusions correctly reflect the poor-quality studies on this topic.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2003

Chronic Heart Failure: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care: Partial Update [Internet]

This guideline is a partial update of NICE Guideline No 5: Chronic Heart Failure - national clinical guideline for diagnosis and management in primary and secondary care (2003). The aim of the 2003 guideline was to offer best practice advice on the care of adult patients (aged 18 years or older) who have symptoms or a diagnosis of chronic heart failure. It defined the most effective combination of symptoms, signs and investigations required to establish a diagnosis of heart failure, and those which would influence therapy or provide important prognostic information. It also gave guidance on the treatment, monitoring and support of patients with heart failure.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: August 2010

Home telemonitoring or structured telephone support programmes after recent discharge in patients with heart failure: systematic review and economic evaluation

Study found that, despite wide variation in usual care and remote monitoring strategies for patients who have been recently discharged (within 28 days) from acute care after a recent exacerbation of heart failure, cost-effectiveness analyses suggested that telemonitoring during office hours is an optimal strategy in most costing scenarios but that further research is needed.

Health Technology Assessment - NIHR Journals Library.

Version: August 2013
Show search results within this document

Meta-analysis of transcatheter closure versus medical therapy for patent foramen ovale in prevention of recurrent neurological events after presumed paradoxical embolism

This review included observational studies of patients with a heart defect (patent foramen ovale) who had a stroke of unknown cause or transient ischaemic attack. The authors concluded that repair of the defect reduced risk of a further neurological event compared with medical therapy. Potential for biases and uncertain quality of the evidence base limit the reliability of this conclusion.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2012

The use of fibrin sealant during non-emergency surgery: a systematic review of evidence of benefits and harms

This study found that the effectiveness of fibrin sealants do not appear to vary according to surgical procedures with regard to reducing the risk of seroma or haematoma.

Health Technology Assessment - NIHR Journals Library.

Version: December 2016
Show search results within this document

Systematic Reviews in PubMed

See all (211)...

Systematic Review Methods in PubMed

See all (2)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...