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Sepsis is a clinical syndrome caused by the body's immune and coagulation systems being switched on by an infection. Sepsis with shock is a life-threatening condition that is characterised by low blood pressure despite adequate fluid replacement, and organ dysfunction or failure. Sepsis is an important cause of death in people of all ages. Both a UK Parliamentary and Health Service Ombudsman enquiry (2013) and UK National Confidential Enquiry into Patient Outcome and Death (NCEPOD, 2015) have recently highlighted sepsis as being a leading cause of avoidable death that kills more people than breast, bowel and prostate cancer combined.

NICE Guideline - National Guideline Centre (UK).

Version: July 2016

This review found that there were few high-quality studies on the effectiveness and cost-effectiveness of drug diversion schemes for Class A drug-using offenders. The majority of the evidence available focused on US methamphetamine users, limiting the transfer of conclusions to the UK. Currently, there is not sufficient evidence to demonstrate whether or not diversionary schemes within England are effective or cost-effective and it is important to note that similarly, there is no evidence that diversion interventions are not effective or cost-effective.

Health Technology Assessment - NIHR Journals Library.

Version: January 2015

It has been estimated that violence accounts for more than 1.6 million deaths worldwide each year and these fatal assaults represent only a fraction of all assaults that actually occur. The problem has widespread consequences for the individual and for the wider society in physical, psychological, social and economic terms. A wide range of pharmacological, psychosocial and organisational interventions have been developed with the aim of addressing the problem. This review was designed to examine the effectiveness of these interventions when they are developed in mental health and criminal justice populations.

Health Technology Assessment - NIHR Journals Library.

Version: February 2012

The authors concluded that the percentage of weight lost as fat-free mass in medical interventions is influenced by the level of calorie restriction, exercise and rate of weight loss, and that diversionary surgery is associated with a greater percentage fat- free mass loss than biliopancreatic laparoscopic adjustable banding. Limitations in reporting and review methods weaken the robustness of the conclusions.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Systematic Reviews in PubMed

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