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Acne is the most common skin disease of adolescence, and in most cases it clears spontaneously. However, in some people it persists in to adulthood. There are many different treatment options, but there is little good evidence to inform doctors and individuals about which to choose.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: August 15, 2012

Non‐cystic fibrosis (CF) bronchiectasis is a chronic respiratory condition characterised by abnormal dilatation of the airways. Although its global prevalence is largely unknown, available data from Australia, New Zealand, the United States and England show that bronchiectasis is now diagnosed with increasing frequency. The lungs of patients with bronchiectasis have excessive secretions, which tend to consist of different types of micro‐organisms. Long‐term antibiotic therapy was proposed to halt persistent and ongoing damage to the lung due to insult from micro‐organisms. Therefore, we seek to assess the effects of prolonged antibiotic therapy on patients with bronchiectasis.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: August 13, 2015

The objectives for the systematic review are to synthesize information on the effectiveness of tympanostomy tubes (TT) in children with chronic otitis media with effusion and recurrent acute otitis media, summarize the frequency of adverse effects or complications associated with TT placement, synthesize information on the necessity for water precautions in children with TT, and assess the effectiveness of available treatments for otorrhea in children who have TT.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: May 2017

This clinical guideline was commissioned by NICE and developed by the National Collaborating Centre for Mental Health. It sets out clear, evidenceand consensus-based recommendations for healthcare staff on how to treat and manage depression in adults with a chronic physical health problem.

NICE Clinical Guidelines - National Collaborating Centre for Mental Health (UK).

Version: 2010

This systematic review found insufficient evidence to draw conclusions about the effectiveness of any intervention for adults with Eustachian tube dysfunction (ETD). The quality of the evidence was generally poor. Evidence was insufficient to allow recommendation of a trial of any particular intervention. Further research is needed to establish a definition of ETD, its relation to broader middle ear ventilation problems and clear diagnostic criteria.

Health Technology Assessment - NIHR Journals Library.

Version: July 2014

Since the publication of the NICE clinical guideline on the prevention of healthcare-associated infections (HCAI) in primary and community care in 2003, many changes have occurred within the NHS that place the patient firmly at the centre of all activities. First, the NHS Constitution for England defines the rights and pledges that every patient can expect regarding their care. To support this, the Care Quality Commission (CQC), the independent regulator of all health and adult social care in England, ensures that health and social care is safe, and monitors how providers comply with established standards. In addition, the legal framework that underpins the guidance has changed since 2003.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: March 2012

Malaria case management, which consists of prompt diagnosis and effective treatment, remains a vital component of malaria control and elimination strategies. This third edition of the WHO Guidelines for the treatment of malaria contains updated recommendations based on new evidence as well as a recommendation on the use of drugs to prevent malaria in high-risk groups.

World Health Organization.

Version: 2015

Two of the five guidelines in the NICE Trauma Suite relate to fractures. These are titled non-complex and complex fractures. In broad terms the non-complex fractures are those likely to be treated at the receiving hospital, whereas the complex fractures require transfer or the consideration of transfer of the injured person to a specialist centre.

NICE Guideline - National Clinical Guideline Centre (UK).

Version: February 2016

All drugs have the potential to cause side effects, also known as ‘adverse drug reactions’, but not all of these are allergic in nature. Other reactions are idiosyncratic, pseudo-allergic or caused by drug intolerance. The British Society for Allergy and Clinical Immunology (BSACI) defines drug allergy as an adverse drug reaction with an established immunological mechanism. The mechanism at presentation may not be apparent from the clinical history and it cannot always be established whether a drug reaction is allergic or non-allergic without investigation. Therefore, this guideline has defined drug allergy as any reaction caused by a drug with clinical features compatible with an immunological mechanism.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: September 2014

BACKGROUND: Many interventions have been described for inherited epidermolysis bullosa (EB), but it is unclear which are beneficial.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

The authors concluded that topical antimicrobial treatment was very effective for acute otitis externa, although there was little difference between different antimicrobials. Their conclusions about the effectiveness of antimicrobials versus placebo are likely to be reliable, but few studies compared the same treatments and this limited comparisons between antimicrobials.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2006

This well-conducted review evaluated the effect of antibiotics on clinical outcomes in patients suffering from exacerbations of chronic obstructive pulmonary disease (COPD). Antibiotics lead to a substantial reduction in treatment failure and mortality rates in COPD patients with severe but not mild to moderate exacerbations. The results of the review are likely to be reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Systematic Reviews in PubMed

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