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Malignant peripheral nerve sheath tumors of the trigeminal nerve: a systematic review of 36 cases

OBJECT: Malignant peripheral nerve sheath tumors (MPNSTs) are a rare form of malignancy arising from the Schwann cells of peripheral nerves. MPNSTs of the trigeminal nerve are exceptionally rare, with only a handful of reports in the literature. These tumors are typically very aggressive, resulting in significant patient morbidity and a generally grim prognosis. Most current reports suggest that radical resection with radiation therapy offers the best benefit. In this study, the authors systematically reviewed the world English-language literature on MPNSTs of the trigeminal nerve to analyze the presentations, treatment options, and outcomes for patients with this disease.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2013

Immune treatments for peripheral neuropathy caused by an IgM paraprotein antibody, which may bind to MAG, a protein on the myelin sheath of nerves

There are several types of antibodies in the human body. They are more or less specifically adapted to recognise a target, usually a 'foreign' protein such as a bit of a bacterium, virus or tumour. In some people too much of one type of antibody is made, called a paraprotein. Some of these paraproteins are of the IgM class (IgM antibodies are usually an 'early attack force' type of antibody). Some of these antibodies may react against myelin‐associated glycoprotein, also known as MAG. MAG is a molecule on the insulating myelin sheath of nerves. The antibody probably results in damage to the nerve myelin to which it is bound and thus causes a specific type of damage to the nerves, known as a peripheral neuropathy. Anti‐MAG paraprotein‐associated peripheral neuropathy is a condition affecting more men than women, most commonly over the age of 60 years. It causes progressive sensory symptoms, unsteadiness and tremor, and sometimes some weakness of the feet and lower legs.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: 2016

Metastatic Spinal Cord Compression: Diagnosis and Management of Patients at Risk of or with Metastatic Spinal Cord Compression

It is difficult to know what the true incidence of metastatic spinal cord compression (MSCC) is in England and Wales because the cases are not systematically recorded. However, evidence from an audit carried out in Scotland between 1997 and 1999 and from a published study from Ontario, Canada, suggests that the incidence may be up to 80 cases per million population per year. This would mean around 4000 cases per year in England and Wales or more than 100 cases per cancer network per year.

NICE Clinical Guidelines - National Collaborating Centre for Cancer (UK).

Version: November 2008
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Wilms Tumor and Other Childhood Kidney Tumors Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of Wilms tumor.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: November 30, 2016

Particle Beam Radiation Therapies for Cancer [Internet]

Radiotherapy with charged particles can potentially deliver maximal doses while minimizing irradiation of surrounding tissues. It may be more effective or less harmful than other forms of radiotherapy for some cancers. Currently, seven centers in the United States have facilities for particle (proton) irradiation, and at least four are under construction, each costing between $100 and $225 million. The aim of this Technical Brief was to survey the evidence on particle beam radiotherapy.

Comparative Effectiveness Technical Briefs - Agency for Healthcare Research and Quality (US).

Version: November 2009
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The Management of Lower Urinary Tract Symptoms in Men [Internet]

The guideline covers men (18 and over) with a clinical working diagnosis of lower urinary tract symptoms (LUTS). Options for conservative, pharmacological, surgical, and complementary or alternative treatments are considered in terms of clinical and cost effectiveness.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: 2010
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Proton Beam Therapy versus Photon Radiotherapy for Adult and Pediatric Oncology Patients: A Review of the Clinical and Cost-Effectiveness [Internet]

There is much interest in increasing the availability of photon therapy — proton beam therapy (PBT) in Canada, but increased costs, implementation concerns, and unsubstantiated comparative clinical benefit and harms compared to other cancer radiotherapy treatments should be considered. This review will evaluate evidence on the comparative clinical and cost-effectiveness of PBT and photon radiotherapy in adult and pediatric patients requiring radiotherapy for the treatment of cancer.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: May 20, 2016
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Heavy Menstrual Bleeding

Heavy menstrual bleeding (HMB) has an adverse effect on the quality of life of many women. It is not a problem associated with significant mortality. Many women seek help from their general practitioners and it is a common reason for referral into secondary care.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: January 2007

Systematic Review and Economic Modelling of the Relative Clinical Benefit and Cost-Effectiveness of Laparoscopic Surgery and Robotic Surgery for Removal of the Prostate in Men with Localised Prostate Cancer

Complete surgical removal of the prostate, radical prostatectomy, is the most frequently used treatment option for men with localised prostate cancer. The use of laparoscopic (keyhole) and robot-assisted surgery has improved operative safety but the comparative effectiveness and cost-effectiveness of these options remains uncertain.

Health Technology Assessment - NIHR Journals Library.

Version: November 2012
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Childhood Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of childhood soft tissue sarcomas.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: February 15, 2017

Adult Central Nervous System Tumors Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of adult central nervous system tumors.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 31, 2017

Unusual Cancers of Childhood Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of unusual cancers of childhood such as cancers of the head and neck, chest, abdomen, reproductive system, skin, and others.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: April 4, 2017

Late Effects of Treatment for Childhood Cancer (PDQ®): Health Professional Version

Expert-reviewed information summary about the health problems that appear after cancer treatment has ended.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: April 14, 2017

Urinary Incontinence in Neurological Disease: Management of Lower Urinary Tract Dysfunction in Neurological Disease

The guideline covers adults and children (from birth) with lower urinary tract dysfunction resulting from neurological disease or injury.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: August 2012
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Gastrointestinal Stromal Tumors Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of Gastrointestinal Stromal Tumors

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: May 10, 2017

Childhood Soft Tissue Sarcoma Treatment (PDQ®): Patient Version

Expert-reviewed information summary about the treatment of childhood soft tissue sarcomas.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: May 15, 2017

Childhood Rhabdomyosarcoma Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of childhood rhabdomyosarcoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: April 6, 2017

Adult Soft Tissue Sarcoma Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of adult soft tissue sarcoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 31, 2017

Neuroblastoma Treatment (PDQ®): Health Professional Version

Expert-reviewed information summary about the treatment of childhood neuroblastoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: April 14, 2017

Urinary Incontinence in Women: The Management of Urinary Incontinence in Women

This guidance is a partial update of National Institute for Health and Care Excellence (NICE) clinical guideline 40 (published October 2006) and will replace it.

NICE Clinical Guidelines - National Collaborating Centre for Women's and Children's Health (UK).

Version: September 2013

Systematic Reviews in PubMed

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