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The aim of this Cochrane Review was to find out if integrated or non‐integrated orbital implants (artificial eyes) are better for treating anophthalmic sockets. Cochrane researchers collected and ana lysed all relevant studies to answer this question and found three studies.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: November 7, 2016

The review found that there was little evidence on the safety and effectiveness of proton radiation for indications of the eye and that better-quality studies were needed. These conclusions appear reliable.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2009

The guideline covers men (18 and over) with a clinical working diagnosis of lower urinary tract symptoms (LUTS). Options for conservative, pharmacological, surgical, and complementary or alternative treatments are considered in terms of clinical and cost effectiveness.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: 2010

Radiotherapy with charged particles can potentially deliver maximal doses while minimizing irradiation of surrounding tissues. It may be more effective or less harmful than other forms of radiotherapy for some cancers. Currently, seven centers in the United States have facilities for particle (proton) irradiation, and at least four are under construction, each costing between $100 and $225 million. The aim of this Technical Brief was to survey the evidence on particle beam radiotherapy.

Comparative Effectiveness Technical Briefs - Agency for Healthcare Research and Quality (US).

Version: November 2009

Retinoblastoma is a cancer that forms in the retina (part of the eye). Sometimes, retinoblastoma is inherited. Patients and their family members may be checked for the disease with eye exams and need genetic counseling. Get information about the symptoms, tests to diagnose, prognosis, and treatment of newly diagnosed and recurrent retinoblastoma in this expert-reviewed summary.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 29, 2018

There are different types of treatments for intraocular melanoma. The most common treatment is surgery. Radiation therapy, photocoagulation, and thermotherapy may also be used to kill cancer cells in the eye. Learn more about the different treatment options for intraocular melanoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: April 9, 2018

The aim of this Cochrane Review was to find out if focal laser therapy in addition to treatment by systemic chemotherapy for retinoblastoma reduces the risk of tumour recurrence.

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet] - John Wiley & Sons, Ltd.

Version: June 7, 2017

Retinoblastoma is a tumor that occurs in heritable and sporadic forms. Heritable disease is defined by the presence of a germline mutation of the RB1 gene. Get detailed information about screening, genetic testing, diagnosis, prognosis, and treatment of newly diagnosed and recurrent retinoblastoma in this summary for clinicians.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 25, 2018

Expert-reviewed information summary about the treatment of intraocular (eye) melanoma.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: February 8, 2018

To determine the safety, efficacy, and evidence for halting disease progression for retinal prosthesis systems (RPSs) and the outcomes that are and could be assessed in future studies of these devices.

Technology Assessments - Agency for Healthcare Research and Quality (US).

Version: September 30, 2016

This study found that the effectiveness of fibrin sealants do not appear to vary according to surgical procedures with regard to reducing the risk of seroma or haematoma.

Health Technology Assessment - NIHR Journals Library.

Version: December 2016

Late effects of cancer treatment can cause serious, disabling, and life-threatening chronic health conditions that adversely affect the health of aging childhood cancer survivors. Learn about subsequent neoplasms and the cardiovascular, cognitive, psychosocial, digestive, endocrine, immune, musculoskeletal, reproductive, and urinary late effects of pediatric cancer treatment in this expert-reviewed summary.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 2, 2018

There is no single universal definition of the upper aerodigestive tract; for the purposes of this guideline, it encompasses the oral cavity, oropharynx, nasopharynx, hypopharynx, larynx, and paranasal sinuses. The vast majority of cancers at these sites are squamous cell carcinomas (National Head and Neck Cancer Audit, 2014). Some other cancers with less common histological diagnoses, such as mucosal melanomas of the upper aerodigestive tract, are also covered by this guideline.

NICE Guideline - National Collaborating Centre for Cancer (UK).

Version: February 2016

Hereditary kidney cancer syndromes include von Hippel-Lindau disease, hereditary leiomyomatosis and renal cell cancer, Birt-Hogg-Dubé syndrome, and hereditary papillary renal carcinoma. Learn about the genetics, clinical manifestations, and management of these hereditary kidney cancer syndromes in this expert-reviewed summary.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: January 10, 2018

This report evaluates the level of evidence currently available to support the effectiveness and safety of using recombinant activated coagulation factor VII (rFVIIa) for clinical indications not approved by the U. S. Food and Drug Administration (FDA). rFVIIa is approved for a variety of uses in hemophilia patients who have developed antibody inhibitors that compromise the use of standard factor replacement. Use of this costly biologic product has expanded beyond these hemophilia-related indications to encompass a range of off-label uses, most of which are in-hospital uses. These uses differ substantially from the drug’s FDA approved label. The purpose of this report is two-fold: (1) To document the full range of clinical indications for which rFVIIa is being used and the types of studies available to evaluate these uses and (2) To provide a comparative effectiveness review of rFVIIa vs. usual care for several in-hospital clinical indications: intracranial hemorrhage, massive bleeding secondary to trauma, and the selected surgical procedures of cardiac surgery, liver transplantation, and prostatectomy.

Comparative Effectiveness Reviews - Agency for Healthcare Research and Quality (US).

Version: May 2010

The purpose of this report is to review the clinical evidence regarding the effects of segregation or solitary confinement on mental and physical health of inmates in correctional facilities and to review the evidence-based guidelines regarding segregation or solitary confinement in correctional facilities.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: December 18, 2015

Expert-reviewed information summary about the genetics of skin cancer — basal cell carcinoma, squamous cell carcinoma, and melanoma — including information about specific gene mutations and related cancer syndromes. The summary also contains information about interventions that may influence the risk of developing skin cancer in individuals who may be genetically susceptible to these syndromes.

PDQ Cancer Information Summaries [Internet] - National Cancer Institute (US).

Version: February 22, 2018

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