Home > Search Results

Results: 13

Clear

This review assessed the efficacy and safety of catheter-tip devices in patients with acute massive pulmonary embolism. The authors suggested that aspiration, fragmentation, and rheolytic techniques could be useful in the management of acute massive pulmonary embolism. These conclusions have to be viewed with caution given the small size and poor quality of the studies included.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2007

Study found that for people with painful osteoporotic vertebral compression fractures refractory to analgesic treatment, percutaneous vertebroplasty and balloon kyphoplasty significantly reduce pain and improve quality of life compared with optimal pain management. However, there is no evidence that either performs better than operative placebo with local anaesthetic. Complications from either procedure are rare but can be serious. Further research is needed to establish whether or not either procedure has a mortality advantage over or utility gain compared with operative placebo with local anaesthetic.

Health Technology Assessment - NIHR Journals Library.

Version: March 2014

This guideline provides guidance on the assessment and management of major trauma, including resuscitation following major blood loss associated with trauma. For the purposes of this guideline, major trauma is defined as an injury or a combination of injuries that are life-threatening and could be life changing because it may result in long-term disability. This guideline covers both the pre-hospital and immediate hospital care of major trauma patients but does not include any management after definitive lifesaving intervention. It has been developed for health practitioners and professionals, patients and carers and commissioners of health services.

NICE Guideline - National Clinical Guideline Centre (UK).

Version: February 2016

This study found that there is evidence of a significant clinical benefit, in terms of reducing restenosis rates, for self-expanding stents, stent graft, endovascular brachytherapy and drug-coated balloons compared with percutaneous transluminal balloon angioplasty and for drug-eluting stents compared with bare-metal stents. If it is assumed that patency translates into beneficial long-term clinical outcomes, then drug-coated balloons and bail-out drug-eluting stents are the enhancements to percutaneous transluminal balloon angioplasty that are most likely to be cost-effective.

Health Technology Assessment - NIHR Journals Library.

Version: February 2014

Study finds that there is still insufficient evidence to advocate a clear benefit of the addition of anti-platelet therapy to anticoagulant therapy, compared with anticoagulant therapy alone, in reducing the risk of vascular events in a population of patients who are at high risk of thromboembolic events resulting from atrial fibrillation

Health Technology Assessment - NIHR Journals Library.

Version: July 2013

Venous thromboembolism (VTE) is a condition in which a blood clot (a thrombus) forms in a vein and then dislodges to travel in the blood (an embolus). A venous thrombus most commonly occurs in the deep veins of the legs or pelvis; this is then called a deep vein thrombosis (DVT). Blood flow through the affected vein can be limited by the clot, and it can cause swelling and pain in the leg. If it dislodges and travels to the lungs, to the pulmonary arteries, it is called a pulmonary embolism (PE), which in some cases may be fatal. VTE as a term includes both DVT and PE. Major risk factors for VTE include a prior history of DVT, age over 60 years, surgery, obesity, prolonged travel, acute medical illness, cancer, immobility, thrombophilia (an abnormal tendency for the blood to clot) and pregnancy.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: June 2012

Acute ischemic strokes are associated with poor outcomes and high healthcare burden. In patients with occlusions of large cerebral vessels, patients with high baseline stroke severity scores as defined by the National Institute of Health Stroke Score (NIHSS), and patients unlikely to benefit or having failed treatment with intravenous (IV) recombinant tissue plasminogen activator (rtPA), there is a need for alternative methods of revascularization which can improve outcomes without increasing the risk for intracranial hemorrhage. The uses of various neurothrombectomy devices (clot retrievers, aspiration/suction devices, snare-like devices, ultrasonography technologies, and lasers) have been examined in these populations. Currently, two neurothrombectomy devices are FDA-cleared through the FDA 510(k) process: the MERCI clot retriever and the Penumbra System. Various ongoing clinical trials are currently evaluating the impact of these devices, as well as other (off-label) neurothrombectomy devices, for the treatment of acute ischemic stroke. The goal of this technical brief is to describe neurothrombectomy devices currently being used or actively investigated in the treatment of patients with acute ischemic stroke and to summarize the evidence supporting their use.

Comparative Effectiveness Technical Briefs - Agency for Healthcare Research and Quality.

Version: January 2011

When myocardial blood flow is acutely impaired (ischaemia), and often not provoked by exertion, a person will commonly suffer more prolonged pain; this is referred to as acute coronary syndrome (ACS). The underlying common pathophysiology of ACS involves the erosion or sudden rupture of an atherosclerotic plaque within the wall of a coronary artery. Exposure of the circulating blood to the cholesterol-rich material within the plaque stimulates blood clotting (thrombosis), which obstructs blood flow within the affected coronary artery. This coronary obstruction may be of short duration, and may not result in myocardial cell damage (necrosis), in which case the clinical syndrome is termed unstable angina. Unstable angina may result in reversible changes on the electrocardiogram (ECG) but does not cause a rise in troponin, a protein released by infarcting myocardial cells. Ischaemia which causes myocardial necrosis (infarction) will result in elevated troponin. When the ischaemia-causing infarction is either short-lived or affects only a small territory of myocardium the ECG will often show either no abnormality or subtle changes. This syndrome is termed non-ST-segment elevation myocardial infarction (NSTEMI). The diagnosis and immediate management of STEMI and the management of unstable angina and NSTEMI is addressed in other NICE Clinical Guidelines (CG95 and CG94).

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: July 2013

A trauma service provides care for people who have sustained physical injuries. These injuries are often the result of an accident but can be sustained in other circumstances. Injuries range from minor to serious life-threatening trauma. The scope of this guidance is the delivery of services for people with major trauma in the initial phase of care, exploring areas of uncertainty and variation.

NICE Guideline - National Clinical Guideline Centre (UK).

Version: February 2016

The purpose of this review, therefore, is to examine the available evidence and evidence-based guidelines on the clinical effectiveness and cost-effectiveness of endovascular therapy (EVT) relative to intravenous (IV) tissue plasminogen activator (tPA) for patients suffering from acute ischemic stroke (AIS). In addition, a review of the costs associated with diagnostic imaging for selecting patients for EVT is included.

Rapid Response Report: Summary with Critical Appraisal - Canadian Agency for Drugs and Technologies in Health.

Version: August 14, 2015

Venous thromboembolism (VTE) is a term used to include the formation of a blood clot (a thrombus) in a vein which may dislodge from its site of origin to travel in the blood, a phenomenon called embolism. A thrombus most commonly occurs in the deep veins of the legs; this is called deep vein thrombosis. A dislodged thrombus that travels to the lungs is known as a pulmonary embolism.

NICE Clinical Guidelines - National Clinical Guideline Centre – Acute and Chronic Conditions (UK).

Version: 2010

The authors concluded that percutaneous mechanical embolectomy to treat acute ischaemic stroke was feasible and may be an option for some patients, but that randomised controlled trials were required. The very poor quality of evidence currently available suggests that these tentative conclusions are justified.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

This review of closed suction drainage following surgical lower limb revascularisation concluded there was no clear evidence that closed suction drainage reduced wound infection, haematoma, seroma or lymphocele formation. However, the small number of studies, small sample sizes, possible methodological heterogeneity and lack of information on data extraction and validity assessment may limit the validity of the conclusions.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2008

Systematic Reviews in PubMed

See all (54)...

Recent Activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...