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The Clinical Effectiveness and Cost-Effectiveness of Primary Stroke Prevention in Children with Sickle Cell Disease: A Systematic Review and Economic Evaluation

Sickle cell disease (SCD) is a recessive genetic blood disorder, caused by a mutation in the β-globin gene. For children with SCD, the risk of stroke is estimated to be up to 250 times higher than in the general childhood population. Transcranial Doppler (TCD) ultrasonography is a non-invasive technique which measures local blood velocity in the proximal portions of large intracranial arteries. Screening with TCD ultrasonography identifies individuals with high cerebral blood velocity; these children are at the highest risk of stroke. A number of primary stroke prevention strategies are currently used in clinical practice in the UK including blood transfusion, treatment with hydroxycarbamide and bone marrow transplantation (BMT). No reviews have yet assessed the clinical effectiveness and cost effectiveness of primary stroke prevention strategies in children with SCD identified to be at high risk of stroke using TCD ultrasonography.

Health Technology Assessment - NIHR Journals Library.

Version: November 2012
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Visual Dysfunction in Patients with Traumatic Brain Injury: A Systematic Review [Internet]

In 2009, approximately 3.5 million people sought treatment related to a traumatic brain injury (TBI) in the United States (U.S.), just over 1% of the U.S. population. Researchers estimate that approximately 15% of Operation Enduring Freedom/Operation Iraqi Freedom/Operation New Dawn (OEF/OIF/OND) U.S. Service Members have incurred TBI during deployment. This equates to 390,000 of the 2.6 million Service Members who have deployed as of 2014. Given that intact visual functioning depends on portions of the brain interacting in complex ways, there are multiple potential mechanisms through which TBI can result in visual dysfunction. To provide relevant data for policymakers, optometrists, ophthalmologists, rehabilitation specialists, and others who provide services for Veterans with TBI history, we conducted a systematic review of the prevalence and types of visual dysfunction in individuals with a history of TBI.

Evidence-based Synthesis Program - Department of Veterans Affairs (US).

Version: September 2014
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Stroke Rehabilitation: Long Term Rehabilitation After Stroke [Internet]

The aim of this guideline development group was to review the structure, processes and interventions currently used in rehabilitation care, and to evaluate whether they improve outcomes for people with stroke. Such studies are complex and research methodologies need to be robust. Evaluation of clinical effectiveness needs studies that have robust theoretical underpinnings, capture changes that are relevant to the treatment evaluated and reflect what is important to patients, and be large enough to allow reliable data interpretation. This guideline reviews some of the available interventions that can be used in stroke rehabilitation, and highlights where there are gaps in the evidence. It is not intended to be comprehensive.

NICE Clinical Guidelines - National Clinical Guideline Centre (UK).

Version: May 23, 2013
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An assessment of the cost-effectiveness of magnetic resonance, including diffusion-weighted imaging, in patients with transient ischaemic attack and minor stroke: a systematic review, meta-analysis and economic evaluation

Study finds that magnetic resonance with diffusion-weighted imaging is not cost-effective for routine transient ischaemic attack/minor stroke investigation.

Health Technology Assessment - NIHR Journals Library.

Version: April 2014
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Ophthalmological adverse effects of (chiropractic) upper spinal manipulation: evidence from recent case reports

This review summarised recent case reports of opthalmological adverse effects of upper spinal manipulation (USM). The author concluded that USM is associated with opthalmological adverse effects of unknown frequency and that research is required to reliably determine the frequency. Despite limitations in the reporting of the review methods, the author's conclusion appears reasonable given the reliance on evidence from case reports.

Database of Abstracts of Reviews of Effects (DARE): Quality-assessed Reviews [Internet] - Centre for Reviews and Dissemination (UK).

Version: 2005

Systematic Reviews in PubMed

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