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Expert Rev Neurother. 2006 Oct;6(10):1465-79.

Chemotherapy and targeted molecular therapies for brain metastases.

Author information

1
Center for Neuro-oncology Dana-Farber/Brigham and Women's Cancer Center, and Division of Neuro-Oncology, Department of Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA. jdrappatz@partners.org

Abstract

As therapy for systemic cancers improves, an increasing number of patients are developing brain metastases. Although conventional therapy with surgery, radiation therapy and radiosurgery has improved the outcome of a significant number of patients, many develop multiple lesions that are not amenable to standard treatments. In this review, the current role of chemotherapy and targeted molecular agents for brain metastases is summarized and future directions are discussed.

PMID:
17078787
DOI:
10.1586/14737175.6.10.1465
[Indexed for MEDLINE]

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