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Osteoglycin Attenuates Cardiac Fibrosis by Suppressing Cardiac myofibroblast proliferation and migration throughAntagonizing LPA3/MMP2/EGFR signaling.

Zuo C, Li X, Huang J, Chen D, Ji K, Yang Y, Xu T, Zhu DL, Yan C, Gao P.

Cardiovasc Res. 2018 Feb 5. doi: 10.1093/cvr/cvy035. [Epub ahead of print]


An update on vinpocetine: New discoveries and clinical implications.

Zhang YS, Li JD, Yan C.

Eur J Pharmacol. 2018 Jan 15;819:30-34. doi: 10.1016/j.ejphar.2017.11.041. Epub 2017 Nov 26. Review.


Glutaredoxin 1 mediates the protective effect of steady laminar flow on endothelial cells against oxidative stress-induced apoptosis via inhibiting Bim.

Li Y, Ren M, Wang X, Cui X, Zhao H, Zhao C, Zhou J, Guo Y, Hu Y, Yan C, Berk B, Wang J.

Sci Rep. 2017 Nov 14;7(1):15539. doi: 10.1038/s41598-017-15672-3.


Model-based vascular elastography improves the detection of flow-induced carotid artery remodeling in mice.

Korshunov VA, Wang H, Ahmed R, Mickelsen DM, Zhou Q, Yan C, Doyley MM.

Sci Rep. 2017 Sep 21;7(1):12081. doi: 10.1038/s41598-017-12321-7.


Phospholipase Cγ1 Mediates Intima Formation Through Akt-Notch1 Signaling Independent of the Phospholipase Activity.

Jiang D, Zhuang J, Peng W, Lu Y, Liu H, Zhao Q, Chi C, Li X, Zhu G, Xu X, Yan C, Xu Y, Ge J, Pang J.

J Am Heart Assoc. 2017 Jul 11;6(7). pii: e005537. doi: 10.1161/JAHA.117.005537.


Vinpocetine Inhibits NF-κB-Dependent Inflammation in Acute Ischemic Stroke Patients.

Zhang F, Yan C, Wei C, Yao Y, Ma X, Gong Z, Liu S, Zang D, Chen J, Shi FD, Hao J.

Transl Stroke Res. 2017 Jul 9. doi: 10.1007/s12975-017-0549-z. [Epub ahead of print]


Cybersecurity and medical devices: A practical guide for cardiac electrophysiologists.

Ransford B, Kramer DB, Foo Kune D, Auto de Medeiros J, Yan C, Xu W, Crawford T, Fu K.

Pacing Clin Electrophysiol. 2017 Aug;40(8):913-917. doi: 10.1111/pace.13102. Epub 2017 Jul 12. Review.


Vinpocetine Attenuates Pathological Cardiac Remodeling by Inhibiting Cardiac Hypertrophy and Fibrosis.

Wu MP, Zhang YS, Xu X, Zhou Q, Li JD, Yan C.

Cardiovasc Drugs Ther. 2017 Apr;31(2):157-166. doi: 10.1007/s10557-017-6719-0.


PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction.

Knight WE, Chen S, Zhang Y, Oikawa M, Wu M, Zhou Q, Miller CL, Cai Y, Mickelsen DM, Moravec C, Small EM, Abe J, Yan C.

Proc Natl Acad Sci U S A. 2016 Oct 20. pii: 201607728. [Epub ahead of print]


Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway.

Wu MP, Zhang YS, Zhou QM, Xiong J, Dong YR, Yan C.

Pharmacol Res. 2016 Feb;104:115-23. doi: 10.1016/j.phrs.2015.12.032. Epub 2015 Dec 30.


Cyclic nucleotide phosphodiesterase 1 and vascular aging.

Yan C.

Clin Sci (Lond). 2015 Dec;129(12):1077-81. doi: 10.1042/CS20150605. Epub 2015 Sep 15.


Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1α and transforming growth factor-β1 expression.

Huang CK, Luo J, Lai KP, Wang R, Pang H, Chang E, Yan C, Sparks J, Lee SO, Cho J, Chang C.

Hypertension. 2015 Oct;66(4):881-91. doi: 10.1161/HYPERTENSIONAHA.115.05654.


The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.

Shi X, O'Neill MM, MacDonnell S, Brookes PS, Yan C, Berk BC.

J Cardiovasc Pharmacol Ther. 2016 Mar;21(2):177-86. doi: 10.1177/1074248415591700. Epub 2015 Jun 30.


Vinpocetine inhibits Streptococcus pneumoniae-induced upregulation of mucin MUC5AC expression via induction of MKP-1 phosphatase in the pathogenesis of otitis media.

Lee JY, Komatsu K, Lee BC, Miyata M, O'Neill Bohn A, Xu H, Yan C, Li JD.

J Immunol. 2015 Jun 15;194(12):5990-8. doi: 10.4049/jimmunol.1401489. Epub 2015 May 13.


Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi.

Susuki-Miyata S, Miyata M, Lee BC, Xu H, Kai H, Yan C, Li JD.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1800-9. doi: 10.1073/pnas.1418716112. Epub 2015 Mar 23.


Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.

Cai Y, Nagel DJ, Zhou Q, Cygnar KD, Zhao H, Li F, Pi X, Knight PA, Yan C.

Circ Res. 2015 Mar 27;116(7):1120-32. doi: 10.1161/CIRCRESAHA.116.304408. Epub 2015 Jan 21.


Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice.

Ruan CC, Ge Q, Li Y, Li XD, Chen DR, Ji KD, Wu YJ, Sheng LJ, Yan C, Zhu DL, Gao PJ.

Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):598-606. doi: 10.1161/ATVBAHA.114.304927. Epub 2015 Jan 8.


Healthcare Engineering Defined: A White Paper.

Chyu MC, Austin T, Calisir F, Chanjaplammootil S, Davis MJ, Favela J, Gan H, Gefen A, Haddas R, Hahn-Goldberg S, Hornero R, Huang YL, Jensen Ø, Jiang Z, Katsanis JS, Lee JA, Lewis G, Lovell NH, Luebbers HT, Morales GG, Matis T, Matthews JT, Mazur L, Ng EY, Oommen KJ, Ormand K, Rohde T, Sánchez-Morillo D, Sanz-Calcedo JG, Sawan M, Shen CL, Shieh JS, Su CT, Sun L, Sun M, Sun Y, Tewolde SN, Williams EA, Yan C, Zhang J, Zhang YT.

J Healthc Eng. 2015;6(4):635-47. doi: 10.1260/2040-2295.6.4.635.


Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT1) knock out mice.

Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC.

PLoS One. 2014 Feb 19;9(2):e89127. doi: 10.1371/journal.pone.0089127. eCollection 2014.


Biological values of acupuncture and chinese herbal medicine: impact on the life science.

Yang YQ, Yan C, Branford-White CJ, Hou XY.

Evid Based Complement Alternat Med. 2014;2014:593921. doi: 10.1155/2014/593921. Epub 2014 Jan 12. No abstract available.

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