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Items: 17


Novel anti-obesity effects of beer hops compound xanthohumol: role of AMPK signaling pathway.

Samuels JS, Shashidharamurthy R, Rayalam S.

Nutr Metab (Lond). 2018 Jun 15;15:42. doi: 10.1186/s12986-018-0277-8. eCollection 2018.


Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice.

Miranda CL, Johnson LA, de Montgolfier O, Elias VD, Ullrich LS, Hay JJ, Paraiso IL, Choi J, Reed RL, Revel JS, Kioussi C, Bobe G, Iwaniec UT, Turner RT, Katzenellenbogen BS, Katzenellenbogen JA, Blakemore PR, Gombart AF, Maier CS, Raber J, Stevens JF.

Sci Rep. 2018 Jan 12;8(1):613. doi: 10.1038/s41598-017-18992-6.


Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms.

Karimi-Sales E, Mohaddes G, Alipour MR.

Pharmacol Res. 2018 Mar;129:177-187. doi: 10.1016/j.phrs.2017.11.022. Epub 2017 Nov 23. Review.


Hop Phytochemicals and Their Potential Role in Metabolic Syndrome Prevention and Therapy.

Dostálek P, Karabín M, Jelínek L.

Molecules. 2017 Oct 19;22(10). pii: E1761. doi: 10.3390/molecules22101761. Review.


Conformational modulation of the farnesoid X receptor by prenylflavonoids: Insights from hydrogen deuterium exchange mass spectrometry (HDX-MS), fluorescence titration and molecular docking studies.

Yang L, Broderick D, Campbell Y, Gombart AF, Stevens JF, Jiang Y, Hsu VL, Bisson WH, Maier CS.

Biochim Biophys Acta. 2016 Dec;1864(12):1667-1677. doi: 10.1016/j.bbapap.2016.08.019. Epub 2016 Sep 3.


Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.

Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF.

Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/ Epub 2016 Mar 11.


Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.

Miyata S, Inoue J, Shimizu M, Sato R.

J Biol Chem. 2015 Aug 14;290(33):20565-79. doi: 10.1074/jbc.M115.656975. Epub 2015 Jul 3.


The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels.

Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C.

Front Physiol. 2015 May 6;6:140. doi: 10.3389/fphys.2015.00140. eCollection 2015. Review.


Effects of xanthohumol-rich hop extract on the differentiation of preadipocytes.

Kiyofuji A, Yui K, Takahashi K, Osada K.

J Oleo Sci. 2014;63(6):593-7. Epub 2014 May 15.


Effects of xanthohumol-rich extract from the hop on fatty acid metabolism in rats fed a high-fat diet.

Yui K, Kiyofuji A, Osada K.

J Oleo Sci. 2014;63(2):159-68. Epub 2014 Jan 14.


A metabolomics-driven elucidation of the anti-obesity mechanisms of xanthohumol.

Kirkwood JS, Legette LL, Miranda CL, Jiang Y, Stevens JF.

J Biol Chem. 2013 Jun 28;288(26):19000-13. doi: 10.1074/jbc.M112.445452. Epub 2013 May 14.


Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats.

Legette LL, Luna AY, Reed RL, Miranda CL, Bobe G, Proteau RR, Stevens JF.

Phytochemistry. 2013 Jul;91:236-41. doi: 10.1016/j.phytochem.2012.04.018. Epub 2012 May 27.


Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes.

Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA.

J Med Food. 2009 Aug;12(4):846-53. doi: 10.1089/jmf.2008.0158.


Xanthohumol from hop (Humulus lupulus L.) is an efficient inhibitor of monocyte chemoattractant protein-1 and tumor necrosis factor-alpha release in LPS-stimulated RAW 264.7 mouse macrophages and U937 human monocytes.

Lupinacci E, Meijerink J, Vincken JP, Gabriele B, Gruppen H, Witkamp RF.

J Agric Food Chem. 2009 Aug 26;57(16):7274-81. doi: 10.1021/jf901244k.


Xanthohumol influences preadipocyte differentiation: implication of antiproliferative and apoptotic effects.

Mendes V, Monteiro R, Pestana D, Teixeira D, Calhau C, Azevedo I.

J Agric Food Chem. 2008 Dec 24;56(24):11631-7. doi: 10.1021/jf802233q.


Enhanced effects of xanthohumol plus honokiol on apoptosis in 3T3-L1 adipocytes.

Yang JY, Della-Fera MA, Rayalam S, Baile CA.

Obesity (Silver Spring). 2008 Jun;16(6):1232-8. doi: 10.1038/oby.2008.66. Epub 2008 Mar 27.

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