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Significance of prohibitin domain family in tumorigenesis and its implication in cancer diagnosis and treatment.

Yang J, Li B, He QY.

Cell Death Dis. 2018 May 21;9(6):580. doi: 10.1038/s41419-018-0661-3.


Xanthohumol exerts protective effects in liver alterations associated with aging.

Fernández-García C, Rancan L, Paredes SD, Montero C, de la Fuente M, Vara E, Tresguerres JAF.

Eur J Nutr. 2018 Mar 13. doi: 10.1007/s00394-018-1657-6. [Epub ahead of print]


Antifibrotic effect of xanthohumol in combination with praziquantel is associated with altered redox status and reduced iron accumulation during liver fluke-associated cholangiocarcinogenesis.

Jamnongkan W, Thanee M, Yongvanit P, Loilome W, Thanan R, Kimawaha P, Boonmars T, Silakit R, Namwat N, Techasen A.

PeerJ. 2018 Jan 22;6:e4281. doi: 10.7717/peerj.4281. eCollection 2018.


Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice.

Miranda CL, Johnson LA, de Montgolfier O, Elias VD, Ullrich LS, Hay JJ, Paraiso IL, Choi J, Reed RL, Revel JS, Kioussi C, Bobe G, Iwaniec UT, Turner RT, Katzenellenbogen BS, Katzenellenbogen JA, Blakemore PR, Gombart AF, Maier CS, Raber J, Stevens JF.

Sci Rep. 2018 Jan 12;8(1):613. doi: 10.1038/s41598-017-18992-6.


Chalcones as putative hepatoprotective agents: Preclinical evidence and molecular mechanisms.

Karimi-Sales E, Mohaddes G, Alipour MR.

Pharmacol Res. 2018 Mar;129:177-187. doi: 10.1016/j.phrs.2017.11.022. Epub 2017 Nov 23. Review.


An iso-α-acid-rich extract from hops (Humulus lupulus) attenuates acute alcohol-induced liver steatosis in mice.

Hege M, Jung F, Sellmann C, Jin C, Ziegenhardt D, Hellerbrand C, Bergheim I.

Nutrition. 2018 Jan;45:68-75. doi: 10.1016/j.nut.2017.07.010. Epub 2017 Jul 27.


Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells.

Chen SF, Chen PY, Hsu HJ, Wu MJ, Yen JH.

J Agric Food Chem. 2017 Sep 13;65(36):7908-7918. doi: 10.1021/acs.jafc.7b02282. Epub 2017 Aug 28.


Xanthohumol Restores Hepatic Glucolipid Metabolism Balance in Type 1 Diabetic Wistar Rats.

Lima-Fontes M, Costa R, Rodrigues I, Soares R.

J Agric Food Chem. 2017 Aug 30;65(34):7433-7439. doi: 10.1021/acs.jafc.7b02595. Epub 2017 Aug 18.


Xanthohumol, a hop-derived prenylated flavonoid, promotes macrophage reverse cholesterol transport.

Hirata H, Uto-Kondo H, Ogura M, Ayaori M, Shiotani K, Ota A, Tsuchiya Y, Ikewaki K.

J Nutr Biochem. 2017 Sep;47:29-34. doi: 10.1016/j.jnutbio.2017.04.011. Epub 2017 Apr 22.


Xanthohumol and 8-prenylnaringenin ameliorate diabetic-related metabolic dysfunctions in mice.

Costa R, Rodrigues I, Guardão L, Rocha-Rodrigues S, Silva C, Magalhães J, Ferreira-de-Almeida M, Negrão R, Soares R.

J Nutr Biochem. 2017 Jul;45:39-47. doi: 10.1016/j.jnutbio.2017.03.006. Epub 2017 Apr 6.


Xanthohumol Prevents DNA Damage by Dietary Carcinogens: Results of a Human Intervention Trial.

Pichler C, Ferk F, Al-Serori H, Huber W, Jäger W, Waldherr M, Mišík M, Kundi M, Nersesyan A, Herbacek I, Knasmueller S.

Cancer Prev Res (Phila). 2017 Feb;10(2):153-160. doi: 10.1158/1940-6207.CAPR-15-0378. Epub 2016 Dec 6.


Xanthohumol improves dysfunctional glucose and lipid metabolism in diet-induced obese C57BL/6J mice.

Miranda CL, Elias VD, Hay JJ, Choi J, Reed RL, Stevens JF.

Arch Biochem Biophys. 2016 Jun 1;599:22-30. doi: 10.1016/ Epub 2016 Mar 11.


Xanthohumol inhibits STAT3 activation pathway leading to growth suppression and apoptosis induction in human cholangiocarcinoma cells.

Dokduang H, Yongvanit P, Namwat N, Pairojkul C, Sangkhamanon S, Yageta MS, Murakami Y, Loilome W.

Oncol Rep. 2016 Apr;35(4):2065-72. doi: 10.3892/or.2016.4584. Epub 2016 Jan 21.


Anticancer effect of xanthohumol induces growth inhibition and apoptosis of human liver cancer through NF-κB/p53-apoptosis signaling pathway.

Zhao X, Jiang K, Liang B, Huang X.

Oncol Rep. 2016 Feb;35(2):669-75. doi: 10.3892/or.2015.4455. Epub 2015 Nov 26.


Induction of NAD(P)H:Quinone Oxidoreductase 1 (NQO1) by Glycyrrhiza Species Used for Women's Health: Differential Effects of the Michael Acceptors Isoliquiritigenin and Licochalcone A.

Hajirahimkhan A, Simmler C, Dong H, Lantvit DD, Li G, Chen SN, Nikolić D, Pauli GF, van Breemen RB, Dietz BM, Bolton JL.

Chem Res Toxicol. 2015 Nov 16;28(11):2130-41. doi: 10.1021/acs.chemrestox.5b00310. Epub 2015 Nov 5.


In vitro structure-toxicity relationship of chalcones in human hepatic stellate cells.

Zenger K, Dutta S, Wolff H, Genton MG, Kraus B.

Toxicology. 2015 Oct 2;336:26-33. doi: 10.1016/j.tox.2015.07.012. Epub 2015 Jul 19.


Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation.

Miyata S, Inoue J, Shimizu M, Sato R.

J Biol Chem. 2015 Aug 14;290(33):20565-79. doi: 10.1074/jbc.M115.656975. Epub 2015 Jul 3.


Xanthohumol inhibits Notch signaling and induces apoptosis in hepatocellular carcinoma.

Kunnimalaiyaan S, Sokolowski KM, Balamurugan M, Gamblin TC, Kunnimalaiyaan M.

PLoS One. 2015 May 26;10(5):e0127464. doi: 10.1371/journal.pone.0127464. eCollection 2015.


The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels.

Weiskirchen R, Mahli A, Weiskirchen S, Hellerbrand C.

Front Physiol. 2015 May 6;6:140. doi: 10.3389/fphys.2015.00140. eCollection 2015. Review.

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