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Items: 1 to 20 of 95


A protein chimera strategy supports production of a model "difficult-to-express" recombinant target.

Hussain H, Fisher DI, Roth RG, Mark Abbott W, Carballo-Amador MA, Warwicker J, Dickson AJ.

FEBS Lett. 2018 Jun 22. doi: 10.1002/1873-3468.13170. [Epub ahead of print]


Interfacial Adsorption of Monoclonal Antibody COE-3 at the Solid/Water Interface.

Pan F, Li Z, Leyshon T, Rouse D, Li R, Smith C, Campana M, Webster JRP, Bishop SM, Narwal R, van der Walle CF, Warwicker J, Lu JR.

ACS Appl Mater Interfaces. 2018 Jan 10;10(1):1306-1316. doi: 10.1021/acsami.7b13332. Epub 2017 Dec 19.


Features of reactive cysteines discovered through computation: from kinase inhibition to enrichment around protein degrons.

Fowler NJ, Blanford CF, de Visser SP, Warwicker J.

Sci Rep. 2017 Nov 27;7(1):16338. doi: 10.1038/s41598-017-15997-z.


Protein-protein interactions in paralogues: Electrostatics modulates specificity on a conserved steric scaffold.

Ivanov SM, Cawley A, Huber RG, Bond PJ, Warwicker J.

PLoS One. 2017 Oct 10;12(10):e0185928. doi: 10.1371/journal.pone.0185928. eCollection 2017.


Erratum to: Charged residues next to transmembrane regions revisited: "Positive-inside rule" is complemented by the "negative inside depletion/outside enrichment rule".

Baker JA, Wong WC, Eisenhaber B, Warwicker J, Eisenhaber F.

BMC Biol. 2017 Aug 18;15(1):72. doi: 10.1186/s12915-017-0410-6. No abstract available.


Prediction of Reduction Potentials of Copper Proteins with Continuum Electrostatics and Density Functional Theory.

Fowler NJ, Blanford CF, Warwicker J, de Visser SP.

Chemistry. 2017 Nov 2;23(61):15436-15445. doi: 10.1002/chem.201702901. Epub 2017 Sep 21.


Charged residues next to transmembrane regions revisited: "Positive-inside rule" is complemented by the "negative inside depletion/outside enrichment rule".

Baker JA, Wong WC, Eisenhaber B, Warwicker J, Eisenhaber F.

BMC Biol. 2017 Jul 24;15(1):66. doi: 10.1186/s12915-017-0404-4. Erratum in: BMC Biol. 2017 Aug 18;15(1):72.


Neutron Reflection Study of Surface Adsorption of Fc, Fab, and the Whole mAb.

Li Z, Li R, Smith C, Pan F, Campana M, Webster JRP, van der Walle CF, Uddin S, Bishop SM, Narwal R, Warwicker J, Lu JR.

ACS Appl Mater Interfaces. 2017 Jul 12;9(27):23202-23211. doi: 10.1021/acsami.7b06131. Epub 2017 Jun 27.


Protein-Sol: a web tool for predicting protein solubility from sequence.

Hebditch M, Carballo-Amador MA, Charonis S, Curtis R, Warwicker J.

Bioinformatics. 2017 Oct 1;33(19):3098-3100. doi: 10.1093/bioinformatics/btx345.


The effect of charge mutations on the stability and aggregation of a human single chain Fv fragment.

Austerberry JI, Dajani R, Panova S, Roberts D, Golovanov AP, Pluen A, van der Walle CF, Uddin S, Warwicker J, Derrick JP, Curtis R.

Eur J Pharm Biopharm. 2017 Jun;115:18-30. doi: 10.1016/j.ejpb.2017.01.019. Epub 2017 Feb 1.


Proofreading of substrate structure by the Twin-Arginine Translocase is highly dependent on substrate conformational flexibility but surprisingly tolerant of surface charge and hydrophobicity changes.

Jones AS, Austerberry JI, Dajani R, Warwicker J, Curtis R, Derrick JP, Robinson C.

Biochim Biophys Acta. 2016 Dec;1863(12):3116-3124. doi: 10.1016/j.bbamcr.2016.09.006. Epub 2016 Sep 13.


Energetics and Dynamics Across the Bcl-2-Regulated Apoptotic Pathway Reveal Distinct Evolutionary Determinants of Specificity and Affinity.

Ivanov SM, Huber RG, Warwicker J, Bond PJ.

Structure. 2016 Nov 1;24(11):2024-2033. doi: 10.1016/j.str.2016.09.006. Epub 2016 Oct 20.


Polyunsaturated fatty acids inhibit Kv1.4 by interacting with positively charged extracellular pore residues.

Farag NE, Jeong D, Claydon T, Warwicker J, Boyett MR.

Am J Physiol Cell Physiol. 2016 Aug 1;311(2):C255-68. doi: 10.1152/ajpcell.00277.2015. Epub 2016 Jun 8.


Energetic Calculations to Decipher pH-Dependent Oligomerization and Domain Swapping of Proteins.

Shingate P, Warwicker J, Sowdhamini R.

PLoS One. 2015 Jun 4;10(6):e0127716. doi: 10.1371/journal.pone.0127716. eCollection 2015.


Computational Tools for Interpreting Ion Channel pH-Dependence.

Sazanavets I, Warwicker J.

PLoS One. 2015 Apr 27;10(4):e0125293. doi: 10.1371/journal.pone.0125293. eCollection 2015.


Breaking and restoring the hydrophobic core of a centromere-binding protein.

Saeed S, Jowitt TA, Warwicker J, Hayes F.

J Biol Chem. 2015 Apr 3;290(14):9273-83. doi: 10.1074/jbc.M115.638148. Epub 2015 Feb 23.


Deciphering complex patterns of class-I HLA-peptide cross-reactivity via hierarchical grouping.

Mukherjee S, Warwicker J, Chandra N.

Immunol Cell Biol. 2015 Jul;93(6):522-32. doi: 10.1038/icb.2015.3. Epub 2015 Feb 24.


Pathophysiologic Changes in Extracellular pH Modulate Parathyroid Calcium-Sensing Receptor Activity and Secretion via a Histidine-Independent Mechanism.

Campion KL, McCormick WD, Warwicker J, Khayat ME, Atkinson-Dell R, Steward MC, Delbridge LW, Mun HC, Conigrave AD, Ward DT.

J Am Soc Nephrol. 2015 Sep;26(9):2163-71. doi: 10.1681/ASN.2014070653. Epub 2015 Jan 2.


Specific ion and buffer effects on protein-protein interactions of a monoclonal antibody.

Roberts D, Keeling R, Tracka M, van der Walle CF, Uddin S, Warwicker J, Curtis R.

Mol Pharm. 2015 Jan 5;12(1):179-93. doi: 10.1021/mp500533c. Epub 2014 Dec 2.


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