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Items: 1 to 20 of 79

1.

Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16.

Dixon-Clarke SE, Shehata SN, Krojer T, Sharpe TD, von Delft F, Sakamoto K, Bullock AN.

Biochem J. 2017 Feb 20;474(5):699-713. doi: 10.1042/BCJ20160941.

PMID:
28057719
2.

Functional and structural characterization of a novel putative cysteine protease cell wall-modifying multi-domain enzyme selected from a microbial metagenome.

Faheem M, Martins-de-Sa D, Vidal JF, Álvares AC, Brandão-Neto J, Bird LE, Tully MD, von Delft F, Souto BM, Quirino BF, Freitas SM, Barbosa JA.

Sci Rep. 2016 Dec 9;6:38031. doi: 10.1038/srep38031.

3.

An overview of heavy-atom derivatization of protein crystals.

Pike AC, Garman EF, Krojer T, von Delft F, Carpenter EP.

Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):303-18. doi: 10.1107/S2059798316000401. Review.

4.

Lessons from ten years of crystallization experiments at the SGC.

Ng JT, Dekker C, Reardon P, von Delft F.

Acta Crystallogr D Struct Biol. 2016 Feb;72(Pt 2):224-35. doi: 10.1107/S2059798315024687.

5.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan YV, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, England KS, Sejberg J, Thai C, Donovan A, Pal A, Scozzafava G, Bennett JM, Kawamura A, Johansson C, Szykowska A, Gileadi C, Burgess-Brown NA, von Delft F, Oppermann U, Walters Z, Shipley J, Raynaud FI, Westaway SM, Prinjha RK, Fedorov O, Burke R, Schofield CJ, Westwood IM, Bountra C, Müller S, van Montfort RL, Brennan PE, Blagg J.

J Med Chem. 2016 Feb 25;59(4):1388-409. doi: 10.1021/acs.jmedchem.5b01635.

6.

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Riemersma M, Froese DS, van Tol W, Engelke UF, Kopec J, van Scherpenzeel M, Ashikov A, Krojer T, von Delft F, Tessari M, Buczkowska A, Swiezewska E, Jae LT, Brummelkamp TR, Manya H, Endo T, van Bokhoven H, Yue WW, Lefeber DJ.

Chem Biol. 2015 Dec 17;22(12):1643-52. doi: 10.1016/j.chembiol.2015.10.014.

7.

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.

England KS, Tumber A, Krojer T, Scozzafava G, Ng SS, Daniel M, Szykowska A, Che K, von Delft F, Burgess-Brown NA, Kawamura A, Schofield CJ, Brennan PE.

Medchemcomm. 2014 Dec 1;5(12):1879-1886.

8.

WONKA: objective novel complex analysis for ensembles of protein-ligand structures.

Bradley AR, Wall ID, von Delft F, Green DV, Deane CM, Marsden BD.

J Comput Aided Mol Des. 2015 Oct;29(10):963-73. doi: 10.1007/s10822-015-9866-z.

9.

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants.

Tsoumpra MK, Muniz JR, Barnett BL, Kwaasi AA, Pilka ES, Kavanagh KL, Evdokimov A, Walter RL, Von Delft F, Ebetino FH, Oppermann U, Russell RG, Dunford JE.

Bone. 2015 Dec;81:478-86. doi: 10.1016/j.bone.2015.08.020.

10.

Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).

Rouka E, Simister PC, Janning M, Kumbrink J, Konstantinou T, Muniz JR, Joshi D, O'Reilly N, Volkmer R, Ritter B, Knapp S, von Delft F, Kirsch KH, Feller SM.

J Biol Chem. 2015 Oct 16;290(42):25275-92. doi: 10.1074/jbc.M115.637207.

11.

Defined PEG smears as an alternative approach to enhance the search for crystallization conditions and crystal-quality improvement in reduced screens.

Chaikuad A, Knapp S, von Delft F.

Acta Crystallogr D Biol Crystallogr. 2015 Aug;71(Pt 8):1627-39. doi: 10.1107/S1399004715007968.

12.

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.

Froese DS, Michaeli A, McCorvie TJ, Krojer T, Sasi M, Melaev E, Goldblum A, Zatsepin M, Lossos A, Álvarez R, Escribá PV, Minassian BA, von Delft F, Kakhlon O, Yue WW.

Hum Mol Genet. 2015 Oct 15;24(20):5667-76. doi: 10.1093/hmg/ddv280.

13.

Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures.

Pike AC, Gomathinayagam S, Swuec P, Berti M, Zhang Y, Schnecke C, Marino F, von Delft F, Renault L, Costa A, Gileadi O, Vindigni A.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4286-91. doi: 10.1073/pnas.1417594112.

14.

A small molecule targeting ALK1 prevents Notch cooperativity and inhibits functional angiogenesis.

Kerr G, Sheldon H, Chaikuad A, Alfano I, von Delft F, Bullock AN, Harris AL.

Angiogenesis. 2015 Apr;18(2):209-17. doi: 10.1007/s10456-014-9457-y.

15.

Application of in situ diffraction in high-throughput structure determination platforms.

Aller P, Sanchez-Weatherby J, Foadi J, Winter G, Lobley CM, Axford D, Ashton AW, Bellini D, Brandao-Neto J, Culurgioni S, Douangamath A, Duman R, Evans G, Fisher S, Flaig R, Hall DR, Lukacik P, Mazzorana M, McAuley KE, Mykhaylyk V, Owen RL, Paterson NG, Romano P, Sandy J, Sorensen T, von Delft F, Wagner A, Warren A, Williams M, Stuart DI, Walsh MA.

Methods Mol Biol. 2015;1261:233-53. doi: 10.1007/978-1-4939-2230-7_13. Review.

PMID:
25502203
16.

Using textons to rank crystallization droplets by the likely presence of crystals.

Ng JT, Dekker C, Kroemer M, Osborne M, von Delft F.

Acta Crystallogr D Biol Crystallogr. 2014 Oct;70(Pt 10):2702-18. doi: 10.1107/S1399004714017581.

17.

Ribosomal oxygenases are structurally conserved from prokaryotes to humans.

Chowdhury R, Sekirnik R, Brissett NC, Krojer T, Ho CH, Ng SS, Clifton IJ, Ge W, Kershaw NJ, Fox GC, Muniz JR, Vollmar M, Phillips C, Pilka ES, Kavanagh KL, von Delft F, Oppermann U, McDonough MA, Doherty AJ, Schofield CJ.

Nature. 2014 Jun 19;510(7505):422-6. doi: 10.1038/nature13263.

18.

Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain.

Ferguson FM, Fedorov O, Chaikuad A, Philpott M, Muniz JR, Felletar I, von Delft F, Heightman T, Knapp S, Abell C, Ciulli A.

J Med Chem. 2013 Dec 27;56(24):10183-7. doi: 10.1021/jm401582c.

19.

Structural insights into functional overlapping and differentiation among myosin V motors.

Nascimento AF, Trindade DM, Tonoli CC, de Giuseppe PO, Assis LH, Honorato RV, de Oliveira PS, Mahajan P, Burgess-Brown NA, von Delft F, Larson RE, Murakami MT.

J Biol Chem. 2013 Nov 22;288(47):34131-45. doi: 10.1074/jbc.M113.507202.

20.

Molecular architecture of the ankyrin SOCS box family of Cul5-dependent E3 ubiquitin ligases.

Muniz JR, Guo K, Kershaw NJ, Ayinampudi V, von Delft F, Babon JJ, Bullock AN.

J Mol Biol. 2013 Sep 9;425(17):3166-77. doi: 10.1016/j.jmb.2013.06.015.

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