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Items: 1 to 20 of 150

1.

The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ.

Cell. 2018 Jul 26;174(3):505-520. doi: 10.1016/j.cell.2018.06.016. Review.

PMID:
30053424
2.

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors.

Patriarchi T, Cho JR, Merten K, Howe MW, Marley A, Xiong WH, Folk RW, Broussard GJ, Liang R, Jang MJ, Zhong H, Dombeck D, von Zastrow M, Nimmerjahn A, Gradinaru V, Williams JT, Tian L.

Science. 2018 Jun 29;360(6396). pii: eaat4422. doi: 10.1126/science.aat4422. Epub 2018 May 31.

PMID:
29853555
3.

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.

Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M.

Neuron. 2018 Jun 6;98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. Epub 2018 May 10.

PMID:
29754753
4.

Catalytic activation of β-arrestin by GPCRs.

Eichel K, Jullié D, Barsi-Rhyne B, Latorraca NR, Masureel M, Sibarita JB, Dror RO, von Zastrow M.

Nature. 2018 May;557(7705):381-386. doi: 10.1038/s41586-018-0079-1. Epub 2018 May 2.

PMID:
29720660
5.

Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras.

Liang SI, van Lengerich B, Eichel K, Cha M, Patterson DM, Yoon TY, von Zastrow M, Jura N, Gartner ZJ.

Cell Rep. 2018 Mar 6;22(10):2593-2600. doi: 10.1016/j.celrep.2018.02.031.

6.

Subcellular Organization of GPCR Signaling.

Eichel K, von Zastrow M.

Trends Pharmacol Sci. 2018 Feb;39(2):200-208. doi: 10.1016/j.tips.2017.11.009. Epub 2018 Jan 28. Review.

PMID:
29478570
7.

Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.

Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C.

Nat Genet. 2018 Feb;50(2):180-185. doi: 10.1038/s41588-017-0020-9. Epub 2018 Jan 8.

8.

Time-gated detection of protein-protein interactions with transcriptional readout.

Kim MW, Wang W, Sanchez MI, Coukos R, von Zastrow M, Ting AY.

Elife. 2017 Nov 30;6. pii: e30233. doi: 10.7554/eLife.30233.

9.

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.

O'Hayre M, Eichel K, Avino S, Zhao X, Steffen DJ, Feng X, Kawakami K, Aoki J, Messer K, Sunahara R, Inoue A, von Zastrow M, Gutkind JS.

Sci Signal. 2017 Jun 20;10(484). pii: eaal3395. doi: 10.1126/scisignal.aal3395.

10.

Functional selectivity of GPCR-directed drug action through location bias.

Irannejad R, Pessino V, Mika D, Huang B, Wedegaertner PB, Conti M, von Zastrow M.

Nat Chem Biol. 2017 Jul;13(7):799-806. doi: 10.1038/nchembio.2389. Epub 2017 May 29.

11.

An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells.

Lobingier BT, Hüttenhain R, Eichel K, Miller KB, Ting AY, von Zastrow M, Krogan NJ.

Cell. 2017 Apr 6;169(2):350-360.e12. doi: 10.1016/j.cell.2017.03.022.

12.

G Protein-Coupled Receptor Endocytosis Confers Uniformity in Responses to Chemically Distinct Ligands.

Tsvetanova NG, Trester-Zedlitz M, Newton BW, Riordan DP, Sundaram AB, Johnson JR, Krogan NJ, von Zastrow M.

Mol Pharmacol. 2017 Feb;91(2):145-156. doi: 10.1124/mol.116.106369. Epub 2016 Nov 22.

13.

Retromer Endosome Exit Domains Serve Multiple Trafficking Destinations and Regulate Local G Protein Activation by GPCRs.

Varandas KC, Irannejad R, von Zastrow M.

Curr Biol. 2016 Dec 5;26(23):3129-3142. doi: 10.1016/j.cub.2016.09.052. Epub 2016 Nov 10.

14.

Endosomal Phosphatidylinositol 3-Kinase Is Essential for Canonical GPCR Signaling.

Uchida Y, Rutaganira FU, Jullié D, Shokat KM, von Zastrow M.

Mol Pharmacol. 2017 Jan;91(1):65-73. Epub 2016 Nov 7.

15.

GIV/Girdin activates Gαi and inhibits Gαs via the same motif.

Gupta V, Bhandari D, Leyme A, Aznar N, Midde KK, Lo IC, Ear J, Niesman I, López-Sánchez I, Blanco-Canosa JB, von Zastrow M, Garcia-Marcos M, Farquhar MG, Ghosh P.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):E5721-30. doi: 10.1073/pnas.1609502113. Epub 2016 Sep 12.

16.

Molecular Pharmacology of δ-Opioid Receptors.

Gendron L, Cahill CM, von Zastrow M, Schiller PW, Pineyro G.

Pharmacol Rev. 2016 Jul;68(3):631-700. doi: 10.1124/pr.114.008979. Review.

17.

The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor.

Tian X, Irannejad R, Bowman SL, Du Y, Puthenveedu MA, von Zastrow M, Benovic JL.

J Biol Chem. 2016 Jul 8;291(28):14510-25. doi: 10.1074/jbc.M116.716589. Epub 2016 May 11.

18.

β-Arrestin drives MAP kinase signalling from clathrin-coated structures after GPCR dissociation.

Eichel K, Jullié D, von Zastrow M.

Nat Cell Biol. 2016 Mar;18(3):303-10. doi: 10.1038/ncb3307. Epub 2016 Feb 1.

19.
20.

Effects of endocytosis on receptor-mediated signaling.

Irannejad R, Tsvetanova NG, Lobingier BT, von Zastrow M.

Curr Opin Cell Biol. 2015 Aug;35:137-43. doi: 10.1016/j.ceb.2015.05.005. Epub 2015 Jun 6. Review.

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