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Items: 1 to 20 of 35

1.

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems.

Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu WL, Sánchez-Guardado L, Lois C, Mazmanian SK, Deverman BE, Gradinaru V.

Nat Neurosci. 2017 Aug;20(8):1172-1179. doi: 10.1038/nn.4593. Epub 2017 Jun 26.

PMID:
28671695
2.

Dorsal Raphe Dopamine Neurons Modulate Arousal and Promote Wakefulness by Salient Stimuli.

Cho JR, Treweek JB, Robinson JE, Xiao C, Bremner LR, Greenbaum A, Gradinaru V.

Neuron. 2017 Jun 21;94(6):1205-1219.e8. doi: 10.1016/j.neuron.2017.05.020. Epub 2017 Jun 8.

3.

Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex.

Allen WE, Kauvar IV, Chen MZ, Richman EB, Yang SJ, Chan K, Gradinaru V, Deverman BE, Luo L, Deisseroth K.

Neuron. 2017 May 17;94(4):891-907.e6. doi: 10.1016/j.neuron.2017.04.017.

4.

Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow.

Greenbaum A, Chan KY, Dobreva T, Brown D, Balani DH, Boyce R, Kronenberg HM, McBride HJ, Gradinaru V.

Sci Transl Med. 2017 Apr 26;9(387). pii: eaah6518. doi: 10.1126/scitranslmed.aah6518.

PMID:
28446689
5.

Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins.

Bedbrook CN, Rice AJ, Yang KK, Ding X, Chen S, LeProust EM, Gradinaru V, Arnold FH.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):E2624-E2633. doi: 10.1073/pnas.1700269114. Epub 2017 Mar 10.

PMID:
28283661
6.

Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore.

Herwig L, Rice AJ, Bedbrook CN, Zhang RK, Lignell A, Cahn JK, Renata H, Dodani SC, Cho I, Cai L, Gradinaru V, Arnold FH.

Cell Chem Biol. 2017 Mar 16;24(3):415-425. doi: 10.1016/j.chembiol.2017.02.008. Epub 2017 Mar 2.

PMID:
28262559
7.

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease.

Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, Challis C, Schretter CE, Rocha S, Gradinaru V, Chesselet MF, Keshavarzian A, Shannon KM, Krajmalnik-Brown R, Wittung-Stafshede P, Knight R, Mazmanian SK.

Cell. 2016 Dec 1;167(6):1469-1480.e12. doi: 10.1016/j.cell.2016.11.018.

8.

Exposing the Three-Dimensional Biogeography and Metabolic States of Pathogens in Cystic Fibrosis Sputum via Hydrogel Embedding, Clearing, and rRNA Labeling.

DePas WH, Starwalt-Lee R, Van Sambeek L, Ravindra Kumar S, Gradinaru V, Newman DK.

MBio. 2016 Sep 27;7(5). pii: e00796-16. doi: 10.1128/mBio.00796-16.

9.

Regional glutamine deficiency in tumours promotes dedifferentiation through inhibition of histone demethylation.

Pan M, Reid MA, Lowman XH, Kulkarni RP, Tran TQ, Liu X, Yang Y, Hernandez-Davies JE, Rosales KK, Li H, Hugo W, Song C, Xu X, Schones DE, Ann DK, Gradinaru V, Lo RS, Locasale JW, Kong M.

Nat Cell Biol. 2016 Oct;18(10):1090-101. doi: 10.1038/ncb3410. Epub 2016 Sep 12.

10.

Extracting structural and functional features of widely distributed biological circuits with single cell resolution via tissue clearing and delivery vectors.

Treweek JB, Gradinaru V.

Curr Opin Biotechnol. 2016 Aug;40:193-207. doi: 10.1016/j.copbio.2016.03.012. Epub 2016 Jul 6. Review.

11.

Single-molecule RNA detection at depth by hybridization chain reaction and tissue hydrogel embedding and clearing.

Shah S, Lubeck E, Schwarzkopf M, He TF, Greenbaum A, Sohn CH, Lignell A, Choi HM, Gradinaru V, Pierce NA, Cai L.

Development. 2016 Aug 1;143(15):2862-7. doi: 10.1242/dev.138560. Epub 2016 Jun 24.

12.

Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways.

Xiao C, Cho JR, Zhou C, Treweek JB, Chan K, McKinney SL, Yang B, Gradinaru V.

Neuron. 2016 Apr 20;90(2):333-47. doi: 10.1016/j.neuron.2016.03.028.

13.

Cre-dependent selection yields AAV variants for widespread gene transfer to the adult brain.

Deverman BE, Pravdo PL, Simpson BP, Kumar SR, Chan KY, Banerjee A, Wu WL, Yang B, Huber N, Pasca SP, Gradinaru V.

Nat Biotechnol. 2016 Feb;34(2):204-9. doi: 10.1038/nbt.3440. Epub 2016 Feb 1.

14.

Neuroscience: Fluorescent boost for voltage sensors.

Gradinaru V, Flytzanis NC.

Nature. 2016 Jan 28;529(7587):469-70. doi: 10.1038/529469a. No abstract available.

PMID:
26819038
15.

Genomic Reconstruction of an Uncultured Hydrothermal Vent Gammaproteobacterial Methanotroph (Family Methylothermaceae) Indicates Multiple Adaptations to Oxygen Limitation.

Skennerton CT, Ward LM, Michel A, Metcalfe K, Valiente C, Mullin S, Chan KY, Gradinaru V, Orphan VJ.

Front Microbiol. 2015 Dec 23;6:1425. doi: 10.3389/fmicb.2015.01425. eCollection 2015.

16.

Whole-body tissue stabilization and selective extractions via tissue-hydrogel hybrids for high-resolution intact circuit mapping and phenotyping.

Treweek JB, Chan KY, Flytzanis NC, Yang B, Deverman BE, Greenbaum A, Lignell A, Xiao C, Cai L, Ladinsky MS, Bjorkman PJ, Fowlkes CC, Gradinaru V.

Nat Protoc. 2015 Nov;10(11):1860-1896. doi: 10.1038/nprot.2015.122. Epub 2015 Oct 22.

17.

Genetically Encoded Spy Peptide Fusion System to Detect Plasma Membrane-Localized Proteins In Vivo.

Bedbrook CN, Kato M, Ravindra Kumar S, Lakshmanan A, Nath RD, Sun F, Sternberg PW, Arnold FH, Gradinaru V.

Chem Biol. 2015 Aug 20;22(8):1108-21. doi: 10.1016/j.chembiol.2015.06.020. Epub 2015 Jul 23.

18.

Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons.

Flytzanis NC, Bedbrook CN, Chiu H, Engqvist MK, Xiao C, Chan KY, Sternberg PW, Arnold FH, Gradinaru V.

Nat Commun. 2014 Sep 15;5:4894. doi: 10.1038/ncomms5894.

19.

Directed evolution of a far-red fluorescent rhodopsin.

McIsaac RS, Engqvist MK, Wannier T, Rosenthal AZ, Herwig L, Flytzanis NC, Imasheva ES, Lanyi JK, Balashov SP, Gradinaru V, Arnold FH.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13034-9. doi: 10.1073/pnas.1413987111. Epub 2014 Aug 25.

20.

Single-cell phenotyping within transparent intact tissue through whole-body clearing.

Yang B, Treweek JB, Kulkarni RP, Deverman BE, Chen CK, Lubeck E, Shah S, Cai L, Gradinaru V.

Cell. 2014 Aug 14;158(4):945-58. doi: 10.1016/j.cell.2014.07.017. Epub 2014 Jul 31.

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