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Items: 1 to 20 of 175

1.

Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9*30.

Louet M, Labbé CM, Fagnen C, Aono CM, Homem-de-Mello P, Villoutreix BO, Miteva MA.

PLoS One. 2018 May 10;13(5):e0197249. doi: 10.1371/journal.pone.0197249. eCollection 2018.

2.

Breast Cancer Targeting through Inhibition of the Endoplasmic Reticulum-Based Apoptosis Regulator Nrh/BCL2L10.

Nougarede A, Popgeorgiev N, Kassem L, Omarjee S, Borel S, Mikaelian I, Lopez J, Gadet R, Marcillat O, Treilleux I, Villoutreix BO, Rimokh R, Gillet G.

Cancer Res. 2018 Mar 15;78(6):1404-1417. doi: 10.1158/0008-5472.CAN-17-0846. Epub 2018 Jan 12.

PMID:
29330143
3.

Expression and functional characterization of two natural heparin-binding site variants of antithrombin.

Dinarvand P, Yang L, Villoutreix BO, Rezaie AR.

J Thromb Haemost. 2018 Feb;16(2):330-341. doi: 10.1111/jth.13920. Epub 2018 Jan 8.

PMID:
29215785
4.

Identification of insulin-sensitizing molecules acting by disrupting the interaction between the Insulin Receptor and Grb14.

Gondoin A, Hampe C, Eudes R, Fayolle C, Pierre-Eugène C, Miteva M, Villoutreix BO, Charnay-Pouget F, Aitken DJ, Issad T, Burnol AF.

Sci Rep. 2017 Dec 4;7(1):16901. doi: 10.1038/s41598-017-17122-6.

5.

FAF-Drugs4: free ADME-tox filtering computations for chemical biology and early stages drug discovery.

Lagorce D, Bouslama L, Becot J, Miteva MA, Villoutreix BO.

Bioinformatics. 2017 Nov 15;33(22):3658-3660. doi: 10.1093/bioinformatics/btx491.

PMID:
28961788
6.

In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening.

Louet M, Bitam S, Bakouh N, Bignon Y, Planelles G, Lagorce D, Miteva MA, Eladari D, Teulon J, Villoutreix BO.

Sci Rep. 2017 Aug 3;7(1):7249. doi: 10.1038/s41598-017-07794-5.

7.

Pan-assay interference compounds (PAINS) that may not be too painful for chemical biology projects.

Lagorce D, Oliveira N, Miteva MA, Villoutreix BO.

Drug Discov Today. 2017 Aug;22(8):1131-1133. doi: 10.1016/j.drudis.2017.05.017. Epub 2017 Jul 1. No abstract available.

PMID:
28676405
8.

AMMOS2: a web server for protein-ligand-water complexes refinement via molecular mechanics.

Labbé CM, Pencheva T, Jereva D, Desvillechabrol D, Becot J, Villoutreix BO, Pajeva I, Miteva MA.

Nucleic Acids Res. 2017 Jul 3;45(W1):W350-W355. doi: 10.1093/nar/gkx397.

9.

Gly74Ser mutation in protein C causes thrombosis due to a defect in protein S-dependent anticoagulant function.

Chen C, Yang L, Villoutreix BO, Wang X, Ding Q, Rezaie AR.

Thromb Haemost. 2017 Jun 28;117(7):1358-1369. doi: 10.1160/TH17-01-0043. Epub 2017 Apr 13.

PMID:
28405673
10.

Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors.

Lagorce D, Douguet D, Miteva MA, Villoutreix BO.

Sci Rep. 2017 Apr 11;7:46277. doi: 10.1038/srep46277.

11.

Computational Biology and Chemistry in MTi: Emphasis on the Prediction of Some ADMET Properties.

Miteva MA, Villoutreix BO.

Mol Inform. 2017 Oct;36(10). doi: 10.1002/minf.201700008. Epub 2017 Feb 21. Review.

PMID:
28221002
12.

Acute genetic ablation of pendrin lowers blood pressure in mice.

Trepiccione F, Soukaseum C, Baudrie V, Kumai Y, Teulon J, Villoutreix B, Cornière N, Wangemann P, Griffith AJ, Byung Choi Y, Hadchouel J, Chambrey R, Eladari D.

Nephrol Dial Transplant. 2017 Jul 1;32(7):1137-1145. doi: 10.1093/ndt/gfw393.

PMID:
28064162
13.

Blockade of the malignant phenotype by β-subunit selective noncovalent inhibition of immuno- and constitutive proteasomes.

Villoutreix BO, Khatib AM, Cheng Y, Miteva MA, Maréchal X, Vidal J, Reboud-Ravaux M.

Oncotarget. 2017 Feb 7;8(6):10437-10449. doi: 10.18632/oncotarget.14428.

14.

Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism.

Isvoran A, Louet M, Vladoiu DL, Craciun D, Loriot MA, Villoutreix BO, Miteva MA.

Drug Discov Today. 2017 Feb;22(2):366-376. doi: 10.1016/j.drudis.2016.09.015. Epub 2016 Sep 28. Review.

PMID:
27693711
15.

A Cell-Penetrating Peptide Targeting AAC-11 Specifically Induces Cancer Cells Death.

Jagot-Lacoussiere L, Kotula E, Villoutreix BO, Bruzzoni-Giovanelli H, Poyet JL.

Cancer Res. 2016 Sep 15;76(18):5479-90. doi: 10.1158/0008-5472.CAN-16-0302. Epub 2016 Jul 12.

16.

Discoidin Domains as Emerging Therapeutic Targets.

Villoutreix BO, Miteva MA.

Trends Pharmacol Sci. 2016 Aug;37(8):641-659. doi: 10.1016/j.tips.2016.06.003. Epub 2016 Jun 29. Review.

PMID:
27372370
17.

Combining bioinformatics, chemoinformatics and experimental approaches to design chemical probes: Applications in the field of blood coagulation.

Villoutreix BO.

Ann Pharm Fr. 2016 Jul;74(4):253-66. doi: 10.1016/j.pharma.2016.03.006. Epub 2016 Apr 28. Review.

PMID:
27133312
18.

Genetic polymorphisms associated with increased risk of developing chronic myelogenous leukemia.

Bruzzoni-Giovanelli H, González JR, Sigaux F, Villoutreix BO, Cayuela JM, Guilhot J, Preudhomme C, Guilhot F, Poyet JL, Rousselot P.

Oncotarget. 2015 Nov 3;6(34):36269-77. doi: 10.18632/oncotarget.5915.

19.

iPPI-DB: an online database of modulators of protein-protein interactions.

Labbé CM, Kuenemann MA, Zarzycka B, Vriend G, Nicolaes GA, Lagorce D, Miteva MA, Villoutreix BO, Sperandio O.

Nucleic Acids Res. 2016 Jan 4;44(D1):D542-7. doi: 10.1093/nar/gkv982. Epub 2015 Oct 1.

20.

Integrated structure- and ligand-based in silico approach to predict inhibition of cytochrome P450 2D6.

Martiny VY, Carbonell P, Chevillard F, Moroy G, Nicot AB, Vayer P, Villoutreix BO, Miteva MA.

Bioinformatics. 2015 Dec 15;31(24):3930-7. doi: 10.1093/bioinformatics/btv486. Epub 2015 Aug 26.

PMID:
26315915

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