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Items: 1 to 20 of 24


Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain.

Gontier G, Iyer M, Shea JM, Bieri G, Wheatley EG, Ramalho-Santos M, Villeda SA.

Cell Rep. 2018 Feb 20;22(8):1974-1981. doi: 10.1016/j.celrep.2018.02.001.


The systemic environment: at the interface of aging and adult neurogenesis.

Smith LK, White CW 3rd, Villeda SA.

Cell Tissue Res. 2018 Jan;371(1):105-113. doi: 10.1007/s00441-017-2715-8. Epub 2017 Nov 9. Review.


Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner.

Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, Singer O, David E, Winter DR, Smith LK, Kertser A, Baruch K, Rosenzweig N, Terem A, Prinz M, Villeda S, Citri A, Amit I, Schwartz M.

Nat Commun. 2017 Sep 28;8(1):717. doi: 10.1038/s41467-017-00769-0.


Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease.

Horowitz AM, Villeda SA.

F1000Res. 2017 Aug 1;6:1291. doi: 10.12688/f1000research.11437.1. eCollection 2017. Review.


Mechanisms of Hippocampal Aging and the Potential for Rejuvenation.

Fan X, Wheatley EG, Villeda SA.

Annu Rev Neurosci. 2017 Jul 25;40:251-272. doi: 10.1146/annurev-neuro-072116-031357. Epub 2017 Apr 24. Review.


Post-Babesiosis Warm Autoimmune Hemolytic Anemia.

Woolley AE, Montgomery MW, Savage WJ, Achebe MO, Dunford K, Villeda S, Maguire JH, Marty FM.

N Engl J Med. 2017 Mar 9;376(10):939-946. doi: 10.1056/NEJMoa1612165.


Microglia communication: Parallels between aging and Alzheimer's disease.

Udeochu JC, Shea JM, Villeda SA.

Clin Exp Neuroimmunol. 2016 May;7(2):114-125. Epub 2016 May 3. Review.


Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.

Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T.

JAMA Neurol. 2016 Nov 1;73(11):1325-1333. doi: 10.1001/jamaneurol.2016.3185.


Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node.

Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG.

Elife. 2016 Aug 3;5. pii: e18156. doi: 10.7554/eLife.18156.


Translational strategies in aging and age-related disease.

Armanios M, de Cabo R, Mannick J, Partridge L, van Deursen J, Villeda S.

Nat Med. 2015 Dec;21(12):1395-9. doi: 10.1038/nm.4004.


Fat Chance for Neural Stem Cells in Alzheimer's Disease.

Gontier G, Lin K, Villeda SA.

Cell Stem Cell. 2015 Oct 1;17(4):373-4. doi: 10.1016/j.stem.2015.09.006.


β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis.

Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, Luo J, Wyss-Coray T, Villeda SA.

Nat Med. 2015 Aug;21(8):932-7. doi: 10.1038/nm.3898. Epub 2015 Jul 6.


Aging and brain rejuvenation as systemic events.

Bouchard J, Villeda SA.

J Neurochem. 2015 Jan;132(1):5-19. doi: 10.1111/jnc.12969. Epub 2014 Dec 5. Review.


ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis.

He Y, Zhang H, Yung A, Villeda SA, Jaeger PA, Olayiwola O, Fainberg N, Wyss-Coray T.

Nat Neurosci. 2014 Jul;17(7):943-52. doi: 10.1038/nn.3732. Epub 2014 May 25.


Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T.

Nat Med. 2014 Jun;20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4.


Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury.

Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS, Wyss-Coray T.

Front Neurol. 2014 Feb 4;5:12. doi: 10.3389/fneur.2014.00012. eCollection 2014.


Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival.

Luo J, Elwood F, Britschgi M, Villeda S, Zhang H, Ding Z, Zhu L, Alabsi H, Getachew R, Narasimhan R, Wabl R, Fainberg N, James ML, Wong G, Relton J, Gambhir SS, Pollard JW, Wyss-Coray T.

J Exp Med. 2013 Jan 14;210(1):157-72. doi: 10.1084/jem.20120412. Epub 2013 Jan 7.


The circulatory systemic environment as a modulator of neurogenesis and brain aging.

Villeda SA, Wyss-Coray T.

Autoimmun Rev. 2013 Apr;12(6):674-7. doi: 10.1016/j.autrev.2012.10.014. Epub 2012 Nov 29. Review.


The ageing systemic milieu negatively regulates neurogenesis and cognitive function.

Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, Li G, Peskind ER, Kaye JA, Quinn JF, Galasko DR, Xie XS, Rando TA, Wyss-Coray T.

Nature. 2011 Aug 31;477(7362):90-4. doi: 10.1038/nature10357.


Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis.

Moriyama M, Fukuhara T, Britschgi M, He Y, Narasimhan R, Villeda S, Molina H, Huber BT, Holers M, Wyss-Coray T.

J Neurosci. 2011 Mar 16;31(11):3981-9. doi: 10.1523/JNEUROSCI.3617-10.2011.

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