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Items: 1 to 20 of 55

1.

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells.

Annala S, Feng X, Shridhar N, Eryilmaz F, Patt J, Yang J, Pfeil EM, Cervantes-Villagrana RD, Inoue A, Häberlein F, Slodczyk T, Reher R, Kehraus S, Monteleone S, Schrage R, Heycke N, Rick U, Engel S, Pfeifer A, Kolb P, König G, Bünemann M, Tüting T, Vázquez-Prado J, Gutkind JS, Gaffal E, Kostenis E.

Sci Signal. 2019 Mar 19;12(573). pii: eaau5948. doi: 10.1126/scisignal.aau5948.

PMID:
30890659
2.

Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs.

Cervantes-Villagrana RD, Color-Aparicio VM, Reyes-Cruz G, Vázquez-Prado J.

J Cell Commun Signal. 2019 Jun;13(2):179-191. doi: 10.1007/s12079-018-00502-6. Epub 2019 Jan 5.

3.

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits.

Adame-García SR, Cervantes-Villagrana RD, Orduña-Castillo LB, Del Rio JC, Gutkind JS, Reyes-Cruz G, Taylor SS, Vázquez-Prado J.

J Biol Chem. 2019 Feb 15;294(7):2232-2246. doi: 10.1074/jbc.RA118.006691. Epub 2018 Dec 10.

4.

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.

Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J.

J Biol Chem. 2019 Jan 11;294(2):531-546. doi: 10.1074/jbc.RA118.006254. Epub 2018 Nov 16.

PMID:
30446620
5.

Calcium sensing receptor activates the NLRP3 inflammasome via a chaperone-assisted degradative pathway involving Hsp70 and LC3-II.

Gutiérrez-López TY, Orduña-Castillo LB, Hernández-Vásquez MN, Vázquez-Prado J, Reyes-Cruz G.

Biochem Biophys Res Commun. 2018 Nov 10;505(4):1121-1127. doi: 10.1016/j.bbrc.2018.10.028. Epub 2018 Oct 11.

PMID:
30316511
6.

VPS28, an ESCRT-I protein, regulates mitotic spindle organization via Gβγ, EG5 and TPX2.

Dionisio-Vicuña MN, Gutiérrez-López TY, Adame-García SR, Vázquez-Prado J, Reyes-Cruz G.

Biochim Biophys Acta Mol Cell Res. 2018 Jul;1865(7):1012-1022. doi: 10.1016/j.bbamcr.2018.03.005. Epub 2018 Mar 14. No abstract available.

7.

Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock.

Hernández-Vásquez MN, Adame-García SR, Hamoud N, Chidiac R, Reyes-Cruz G, Gratton JP, Côté JF, Vázquez-Prado J.

J Biol Chem. 2017 Jul 21;292(29):12178-12191. doi: 10.1074/jbc.M117.780304. Epub 2017 Jun 9.

8.

Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function.

Raya-Sandino A, Castillo-Kauil A, Domínguez-Calderón A, Alarcón L, Flores-Benitez D, Cuellar-Perez F, López-Bayghen B, Chávez-Munguía B, Vázquez-Prado J, González-Mariscal L.

Biochim Biophys Acta Mol Cell Res. 2017 Oct;1864(10):1714-1733. doi: 10.1016/j.bbamcr.2017.05.016. Epub 2017 May 26.

9.

Pro-adhesive phenotype of normal endothelial cells responding to metastatic breast cancer cell conditioned medium is linked to NFκB-mediated transcriptomic regulation.

Mejía-Rangel J, Córdova E, Orozco L, Ventura-Gallegos JL, Mitre-Aguilar I, Escalona-Guzmán A, Vadillo F, Vázquez-Prado J, Gariglio P, Zentella-Dehesa A.

Int J Oncol. 2016 Nov;49(5):2173-2185. doi: 10.3892/ijo.2016.3705. Epub 2016 Sep 26.

PMID:
27666521
10.

Gβγ Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment.

Vázquez-Prado J, Bracho-Valdés I, Cervantes-Villagrana RD, Reyes-Cruz G.

Mol Pharmacol. 2016 Nov;90(5):573-586. Epub 2016 Sep 16. Review.

PMID:
27638873
11.

Calcium-sensing-receptor (CaSR) controls IL-6 secretion in metastatic breast cancer MDA-MB-231 cells by a dual mechanism revealed by agonist and inverse-agonist modulators.

Hernández-Bedolla MA, González-Domínguez E, Zavala-Barrera C, Gutiérrez-López TY, Hidalgo-Moyle JJ, Vázquez-Prado J, Sánchez-Torres C, Reyes-Cruz G.

Mol Cell Endocrinol. 2016 Nov 15;436:159-68. doi: 10.1016/j.mce.2016.07.038. Epub 2016 Jul 29.

PMID:
27477783
12.

Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING.

Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor SS, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J.

J Biol Chem. 2016 Mar 18;291(12):6182-99. doi: 10.1074/jbc.M115.712216. Epub 2016 Jan 21.

13.

Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells.

Hernández-García R, Iruela-Arispe ML, Reyes-Cruz G, Vázquez-Prado J.

Vascul Pharmacol. 2015 Nov;74:60-72. doi: 10.1016/j.vph.2015.10.003. Epub 2015 Oct 17.

PMID:
26471833
14.

Chemotactic and proangiogenic role of calcium sensing receptor is linked to secretion of multiple cytokines and growth factors in breast cancer MDA-MB-231 cells.

Hernández-Bedolla MA, Carretero-Ortega J, Valadez-Sánchez M, Vázquez-Prado J, Reyes-Cruz G.

Biochim Biophys Acta. 2015 Jan;1853(1):166-82. doi: 10.1016/j.bbamcr.2014.10.011. Epub 2014 Oct 22.

15.

Gβγ interacts with mTOR and promotes its activation.

Robles-Molina E, Dionisio-Vicuña M, Guzmán-Hernández ML, Reyes-Cruz G, Vázquez-Prado J.

Biochem Biophys Res Commun. 2014 Feb 7;444(2):218-23. doi: 10.1016/j.bbrc.2014.01.044. Epub 2014 Jan 22.

PMID:
24462769
16.

Calcium-sensing receptor inhibits TGF-β-signaling by decreasing Smad2 phosphorylation.

Organista-Juárez D, Carretero-Ortega J, Vicente-Fermín O, Vázquez-Victorio G, Sosa-Garrocho M, Vázquez-Prado J, Macías-Silva M, Reyes-Cruz G.

IUBMB Life. 2013 Dec;65(12):1035-42. doi: 10.1002/iub.1232. Epub 2013 Nov 24.

17.

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.

O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS.

Nat Rev Cancer. 2013 Jun;13(6):412-24. doi: 10.1038/nrc3521. Epub 2013 May 3. Review.

18.

Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells.

Frausto-Del-Río D, Soto-Cruz I, Garay-Canales C, Ambriz X, Soldevila G, Carretero-Ortega J, Vázquez-Prado J, Ortega E.

Cytokine. 2012 Jan;57(1):158-68. doi: 10.1016/j.cyto.2011.11.008. Epub 2011 Dec 1.

PMID:
22137120
20.

mTORC1- and mTORC2-interacting proteins keep their multifunctional partners focused.

Bracho-Valdés I, Moreno-Alvarez P, Valencia-Martínez I, Robles-Molina E, Chávez-Vargas L, Vázquez-Prado J.

IUBMB Life. 2011 Oct;63(10):896-914. doi: 10.1002/iub.558. Epub 2011 Sep 9. Review.

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