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1.

Drinking Water Nitrate and Human Health: An Updated Review.

Ward MH, Jones RR, Brender JD, de Kok TM, Weyer PJ, Nolan BT, Villanueva CM, van Breda SG.

Int J Environ Res Public Health. 2018 Jul 23;15(7). pii: E1557. doi: 10.3390/ijerph15071557. Review.

2.

Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes.

Wolters JEJ, van Breda SGJ, Grossmann J, Fortes C, Caiment F, Kleinjans JCS.

Toxicol Lett. 2018 Jun 1;289:1-13. doi: 10.1016/j.toxlet.2018.02.026. Epub 2018 Mar 6.

3.

A cross-omics approach to investigate temporal gene expression regulation by 5-hydroxymethylcytosine via TBH-derived oxidative stress showed involvement of different regulatory kinases.

Briedé JJ, Deferme L, Wolters JEJ, Claessen SMH, van den Beucken T, Wagner RJ, van Breda SG, Kleinjans JCS.

Toxicol In Vitro. 2018 Apr;48:318-328. doi: 10.1016/j.tiv.2018.02.006. Epub 2018 Feb 9.

4.

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction.

van Breda SGJ, Claessen SMH, van Herwijnen M, Theunissen DHJ, Jennen DGJ, de Kok TMCM, Kleinjans JCS.

Toxicology. 2018 Jan 15;393:160-170. doi: 10.1016/j.tox.2017.11.013. Epub 2017 Nov 14.

5.

Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases.

van Breda SGJ, de Kok TMCM.

Mol Nutr Food Res. 2018 Jan;62(1). doi: 10.1002/mnfr.201700597. Epub 2017 Dec 19. Review.

PMID:
29108107
6.

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes.

Wolters JEJ, van Breda SGJ, Caiment F, Claessen SM, de Kok TMCM, Kleinjans JCS.

Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.

7.

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

Wolters JE, van Herwijnen MH, Theunissen DH, Jennen DG, Van den Hof WF, de Kok TM, Schaap FG, van Breda SG, Kleinjans JC.

Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174. Epub 2016 Dec 2.

PMID:
27989131
8.

Dynamic Interplay between the Transcriptome and Methylome in Response to Oxidative and Alkylating Stress.

Deferme L, Wolters JE, Claessen SM, Theunissen DH, van den Beucken T, Wagner JR, van Breda SG, Kleinjans JC, Briedé JJ.

Chem Res Toxicol. 2016 Sep 19;29(9):1428-38. doi: 10.1021/acs.chemrestox.6b00090. Epub 2016 Aug 24.

PMID:
27509014
9.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity.

Rieswijk L, Brauers KJ, Coonen ML, Jennen DG, van Breda SG, Kleinjans JC.

Mutagenesis. 2016 Sep;31(5):603-15. doi: 10.1093/mutage/gew027. Epub 2016 Jun 23.

PMID:
27338304
10.

Aflatoxin B1 induces persistent epigenomic effects in primary human hepatocytes associated with hepatocellular carcinoma.

Rieswijk L, Claessen SM, Bekers O, van Herwijnen M, Theunissen DH, Jennen DG, de Kok TM, Kleinjans JC, van Breda SG.

Toxicology. 2016 Mar 28;350-352:31-9. doi: 10.1016/j.tox.2016.05.002. Epub 2016 May 3.

PMID:
27153756
11.

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

Fernando RN, Chaudhari U, Escher SE, Hengstler JG, Hescheler J, Jennings P, Keun HC, Kleinjans JCS, Kolde R, Kollipara L, Kopp-Schneider A, Limonciel A, Nemade H, Nguemo F, Peterson H, Prieto P, Rodrigues RM, Sachinidis A, Schäfer C, Sickmann A, Spitkovsky D, Stöber R, van Breda SGJ, van de Water B, Vivier M, Zahedi RP, Vinken M, Rogiers V.

Arch Toxicol. 2016 Jun;90(6):1529-1539. doi: 10.1007/s00204-016-1719-6. Epub 2016 Apr 29.

12.

Development of novel tools for the in vitro investigation of drug-induced liver injury.

Jiang J, Wolters JE, van Breda SG, Kleinjans JC, de Kok TM.

Expert Opin Drug Metab Toxicol. 2015;11(10):1523-37. doi: 10.1517/17425255.2015.1065814. Epub 2015 Jul 9. Review.

PMID:
26155718
13.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.

Rieswijk L, Brauers KJ, Coonen ML, van Breda SG, Jennen DG, Kleinjans JC.

Mutagenesis. 2015 Nov;30(6):771-84. doi: 10.1093/mutage/gev036. Epub 2015 May 14.

PMID:
25976910
14.

The exposome concept in a human nutrigenomics study: evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures.

van Breda SG, Wilms LC, Gaj S, Jennen DG, Briedé JJ, Kleinjans JC, de Kok TM.

Mutagenesis. 2015 Nov;30(6):723-31. doi: 10.1093/mutage/gev008. Epub 2015 Feb 22. Review.

PMID:
25711498
15.

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis.

van Breda SG, Claessen SM, Lo K, van Herwijnen M, Brauers KJ, Lisanti S, Theunissen DH, Jennen DG, Gaj S, de Kok TM, Kleinjans JC.

Arch Toxicol. 2015 Nov;89(11):1959-69. doi: 10.1007/s00204-014-1351-2. Epub 2014 Sep 9.

PMID:
25199682
16.

Selenoprotein gene variants, toenail selenium levels, and risk for advanced prostate cancer.

Geybels MS, van den Brandt PA, Schouten LJ, van Schooten FJ, van Breda SG, Rayman MP, Green FR, Verhage BA.

J Natl Cancer Inst. 2014 Mar;106(3):dju003. doi: 10.1093/jnci/dju003. Epub 2014 Feb 22.

PMID:
24563517
17.

Can transcriptomics provide insight into the chemopreventive mechanisms of complex mixtures of phytochemicals in humans?

van Breda SG, Wilms LC, Gaj S, Jennen DG, Briedé JJ, Helsper JP, Kleinjans JC, de Kok TM.

Antioxid Redox Signal. 2014 May 10;20(14):2107-13. doi: 10.1089/ars.2013.5528. Epub 2014 Feb 27.

18.

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris).

Pedersen M, von Stedingk H, Botsivali M, Agramunt S, Alexander J, Brunborg G, Chatzi L, Fleming S, Fthenou E, Granum B, Gutzkow KB, Hardie LJ, Knudsen LE, Kyrtopoulos SA, Mendez MA, Merlo DF, Nielsen JK, Rydberg P, Segerbäck D, Sunyer J, Wright J, Törnqvist M, Kleinjans JC, Kogevinas M; NewGeneris Consortium.

Environ Health Perspect. 2012 Dec;120(12):1739-45. doi: 10.1289/ehp.1205327. Epub 2012 Sep 23.

19.

A lyophilized red grape pomace containing proanthocyanidin-rich dietary fiber induces genetic and metabolic alterations in colon mucosa of female C57BL/6J mice.

Lizarraga D, Vinardell MP, Noé V, van Delft JH, Alcarraz-Vizán G, van Breda SG, Staal Y, Günther UL, Carrigan JB, Reed MA, Ciudad CJ, Torres JL, Cascante M.

J Nutr. 2011 Sep;141(9):1597-604. doi: 10.3945/jn.110.133199. Epub 2011 Jul 20. Erratum in: J Nutr. 2012 Feb 1;142(2):396. Carrigan, John B [added].

PMID:
21775529
20.

Dietary acrylamide intake and risk of breast cancer in the UK women's cohort.

Burley VJ, Greenwood DC, Hepworth SJ, Fraser LK, de Kok TM, van Breda SG, Kyrtopoulos SA, Botsivali M, Kleinjans J, McKinney PA, Cade JE.

Br J Cancer. 2010 Nov 23;103(11):1749-54. doi: 10.1038/sj.bjc.6605956. Epub 2010 Oct 19.

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