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Items: 1 to 20 of 171


Interleukin-1/inhibitory kappa B kinase epsilon-induced glycolysis augment epithelial effector function and promote allergic airways disease.

Qian X, Aboushousha R, van de Wetering C, Chia SB, Amiel E, Schneider RW, van der Velden JL, Lahue KG, Hoagland DA, Casey DT, Daphtary N, Ather JL, Randall MJ, Aliyeva M, Black KE, Chapman DG, Lundblad LKA, McMillan DH, Dixon AE, Anathy V, Irvin CG, Poynter ME, Wouters EFM, Vacek PM, Henket M, Schleich F, Louis R, van der Vliet A, Janssen-Heininger YMW.

J Allergy Clin Immunol. 2017 Nov 3. pii: S0091-6749(17)31663-9. doi: 10.1016/j.jaci.2017.08.043. [Epub ahead of print]


Cysteine perthiosulfenic acid (Cys-SSOH): A novel intermediate in thiol-based redox signaling?

Heppner DE, Hristova M, Ida T, Mijuskovic A, Dustin CM, Bogdándi V, Fukuto JM, Dick TP, Nagy P, Li J, Akaike T, van der Vliet A.

Redox Biol. 2017 Oct 9;14:379-385. doi: 10.1016/j.redox.2017.10.006. [Epub ahead of print]


Paradoxical roles of dual oxidases in cancer biology.

Little AC, Sulovari A, Danyal K, Heppner DE, Seward DJ, van der Vliet A.

Free Radic Biol Med. 2017 Sep;110:117-132. doi: 10.1016/j.freeradbiomed.2017.05.024. Epub 2017 May 31. Review.


Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome.

Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, Janssen-Heininger YM, van der Vliet A, Dixon AE, Amiel E, Poynter ME.

Redox Biol. 2017 Aug;12:883-896. doi: 10.1016/j.redox.2017.04.020. Epub 2017 Apr 25.


The role of sulfenic acids in cellular redox signaling: Reconciling chemical kinetics and molecular detection strategies.

Heppner DE, Janssen-Heininger YM, van der Vliet A.

Arch Biochem Biophys. 2017 Feb 15;616:40-46. doi: 10.1016/ Epub 2017 Jan 23.


DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma.

Habibovic A, Hristova M, Heppner DE, Danyal K, Ather JL, Janssen-Heininger YM, Irvin CG, Poynter ME, Lundblad LK, Dixon AE, Geiszt M, van der Vliet A.

JCI Insight. 2016 Nov 3;1(18):e88811.


Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR.

Danyal K, de Jong W, O'Brien E, Bauer RA, Heppner DE, Little AC, Hristova M, Habibovic A, van der Vliet A.

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L913-L923. doi: 10.1152/ajplung.00276.2016. Epub 2016 Sep 9.


The NADPH Oxidases DUOX1 and NOX2 Play Distinct Roles in Redox Regulation of Epidermal Growth Factor Receptor Signaling.

Heppner DE, Hristova M, Dustin CM, Danyal K, Habibovic A, van der Vliet A.

J Biol Chem. 2016 Oct 28;291(44):23282-23293. Epub 2016 Sep 20.


DUOX1 silencing in lung cancer promotes EMT, cancer stem cell characteristics and invasive properties.

Little AC, Sham D, Hristova M, Danyal K, Heppner DE, Bauer RA, Sipsey LM, Habibovic A, van der Vliet A.

Oncogenesis. 2016 Oct 3;5(10):e261. doi: 10.1038/oncsis.2016.61.


Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

McMillan DH, van der Velden JL, Lahue KG, Qian X, Schneider RW, Iberg MS, Nolin JD, Abdalla S, Casey DT, Tew KD, Townsend DM, Henderson CJ, Wolf CR, Butnor KJ, Taatjes DJ, Budd RC, Irvin CG, van der Vliet A, Flemer S, Anathy V, Janssen-Heininger YM.

JCI Insight. 2016 Jun 2;1(8). pii: e85717.


Glutathione S-transferase pi modulates NF-κB activation and pro-inflammatory responses in lung epithelial cells.

Jones JT, Qian X, van der Velden JL, Chia SB, McMillan DH, Flemer S, Hoffman SM, Lahue KG, Schneider RW, Nolin JD, Anathy V, van der Vliet A, Townsend DM, Tew KD, Janssen-Heininger YM.

Redox Biol. 2016 Aug;8:375-82. doi: 10.1016/j.redox.2016.03.005. Epub 2016 Mar 26.


Ablation of Glutaredoxin-1 Modulates House Dust Mite-Induced Allergic Airways Disease in Mice.

Hoffman SM, Qian X, Nolin JD, Chapman DG, Chia SB, Lahue KG, Schneider R, Ather JL, Randall MJ, McMillan DH, Jones JT, Taatjes DJ, Aliyeva M, Daphtary N, Abdalla S, Lundblad LK, Ho YS, Anathy V, Irvin CG, Wouters EF, Reynaert NL, Dixon AE, van der Vliet A, Poynter ME, Janssen-Heininger YM.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):377-86. doi: 10.1165/rcmb.2015-0401OC.


Redox-dependent regulation of epidermal growth factor receptor signaling.

Heppner DE, van der Vliet A.

Redox Biol. 2016 Aug;8:24-7. doi: 10.1016/j.redox.2015.12.002. Epub 2015 Dec 8. Review.


Airway epithelial dual oxidase 1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses.

Hristova M, Habibovic A, Veith C, Janssen-Heininger YM, Dixon AE, Geiszt M, van der Vliet A.

J Allergy Clin Immunol. 2016 May;137(5):1545-1556.e11. doi: 10.1016/j.jaci.2015.10.003. Epub 2015 Nov 17.


The tobacco smoke component acrolein induces glucocorticoid resistant gene expression via inhibition of histone deacetylase.

Randall MJ, Haenen GR, Bouwman FG, van der Vliet A, Bast A.

Toxicol Lett. 2016 Jan 5;240(1):43-9. doi: 10.1016/j.toxlet.2015.10.009. Epub 2015 Oct 19.



Valacchi G, van der Vliet A.

Free Radic Biol Med. 2015 Nov;88(Pt A):1-2. doi: 10.1016/j.freeradbiomed.2015.09.001. No abstract available.


Inhalation of the reactive aldehyde acrolein promotes antigen sensitization to ovalbumin and enhances neutrophilic inflammation.

O'Brien E, Spiess PC, Habibovic A, Hristova M, Bauer RA, Randall MJ, Poynter ME, van der Vliet A.

J Immunotoxicol. 2016;13(2):191-7. doi: 10.3109/1547691X.2015.1033571. Epub 2015 Apr 15.


Exploratory use of docetaxel loaded acid-prepared mesoporous spheres for the treatment of malignant melanoma.

Kaiser S, MacPherson MB, James TA, Emery A, Spiess P, van der Vliet A, Landry CC, Shukla A.

Cancer Nanotechnol. 2015;6:1. Epub 2015 Jan 24.


The glutaredoxin/S-glutathionylation axis regulates interleukin-17A-induced proinflammatory responses in lung epithelial cells in association with S-glutathionylation of nuclear factor κB family proteins.

Nolin JD, Tully JE, Hoffman SM, Guala AS, van der Velden JL, Poynter ME, van der Vliet A, Anathy V, Janssen-Heininger YM.

Free Radic Biol Med. 2014 Aug;73:143-53. doi: 10.1016/j.freeradbiomed.2014.04.028. Epub 2014 May 9.


Identification of DUOX1-dependent redox signaling through protein S-glutathionylation in airway epithelial cells.

Hristova M, Veith C, Habibovic A, Lam YW, Deng B, Geiszt M, Janssen-Heininger YM, van der Vliet A.

Redox Biol. 2014 Jan 15;2:436-46. doi: 10.1016/j.redox.2013.12.030. eCollection 2014.

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