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Items: 1 to 20 of 271

1.

Pharmacokinetic Simulations of Intravitreal Biologicals: Aspects of Drug Delivery to the Posterior and Anterior Segments.

Rimpelä AK, Kiiski I, Deng F, Kidron H, Urtti A.

Pharmaceutics. 2018 Dec 30;11(1). pii: E9. doi: 10.3390/pharmaceutics11010009.

2.

Enhanced Delivery of 4-Thioureidoiminomethylpyridinium Perchlorate in Tuberculosis Models with IgG Functionalized Poly(Lactic Acid)-Based Particles.

Churilov L, Korzhikov-Vlakh V, Sinitsyna E, Polyakov D, Darashkevich O, Poida M, Platonova G, Vinogradova T, Utekhin V, Zabolotnykh N, Zinserling V, Yablonsky P, Urtti A, Tennikova T.

Pharmaceutics. 2018 Dec 21;11(1). pii: E2. doi: 10.3390/pharmaceutics11010002.

3.

Modified cells as potential ocular drug delivery systems.

Tennikova T, Urtti A.

Drug Discov Today. 2018 Dec 15. pii: S1359-6446(18)30402-1. doi: 10.1016/j.drudis.2018.12.004. [Epub ahead of print] Review.

PMID:
30562585
4.

Understanding Molecular Drivers of Melanin Binding To Support Rational Design of Small Molecule Ophthalmic Drugs.

Jakubiak P, Reutlinger M, Mattei P, Schuler F, Urtti A, Alvarez-Sánchez R.

J Med Chem. 2018 Nov 21;61(22):10106-10115. doi: 10.1021/acs.jmedchem.8b01281. Epub 2018 Nov 13.

PMID:
30398862
5.

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K.

Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14.

6.

Accelerated pharmaceutical protein development with integrated cell free expression, purification, and bioconjugation.

Richardson D, Itkonen J, Nievas J, Urtti A, Casteleijn MG.

Sci Rep. 2018 Aug 10;8(1):11967. doi: 10.1038/s41598-018-30435-4.

7.

Esterase activity in porcine and albino rabbit ocular tissues.

Heikkinen EM, Del Amo EM, Ranta VP, Urtti A, Vellonen KS, Ruponen M.

Eur J Pharm Sci. 2018 Oct 15;123:106-110. doi: 10.1016/j.ejps.2018.07.034. Epub 2018 Jul 17.

8.

The effect of light sensitizer localization on the stability of indocyanine green liposomes.

Lajunen T, Nurmi R, Wilbie D, Ruoslahti T, Johansson NG, Korhonen O, Rog T, Bunker A, Ruponen M, Urtti A.

J Control Release. 2018 Aug 28;284:213-223. doi: 10.1016/j.jconrel.2018.06.029. Epub 2018 Jun 28.

9.

Preface.

Bunt C, Urtti A, Thrimawithana T.

Adv Drug Deliv Rev. 2018 Feb 15;126:1-2. doi: 10.1016/j.addr.2018.05.003. No abstract available.

PMID:
29887021
10.

Melanin targeting for intracellular drug delivery: Quantification of bound and free drug in retinal pigment epithelial cells.

Rimpelä AK, Hagström M, Kidron H, Urtti A.

J Control Release. 2018 Aug 10;283:261-268. doi: 10.1016/j.jconrel.2018.05.034. Epub 2018 May 31.

11.

Extended Pharmacokinetic Model of the Rabbit Eye for Intravitreal and Intracameral Injections of Macromolecules: Quantitative Analysis of Anterior and Posterior Elimination Pathways.

Lamminsalo M, Taskinen E, Karvinen T, Subrizi A, Murtomäki L, Urtti A, Ranta VP.

Pharm Res. 2018 May 31;35(8):153. doi: 10.1007/s11095-018-2435-0.

PMID:
29855726
12.

Cisplatin Encapsulation Generates Morphologically Different Multicompartments in the Internal Nanostructures of Nonlamellar Liquid-Crystalline Self-Assemblies.

Azmi IDM, Østergaard J, Stürup S, Gammelgaard B, Urtti A, Moghimi SM, Yaghmur A.

Langmuir. 2018 Jun 5;34(22):6570-6581. doi: 10.1021/acs.langmuir.8b01149. Epub 2018 May 24.

PMID:
29768016
13.

Binding of Small Molecule Drugs to Porcine Vitreous Humor.

Rimpelä AK, Reunanen S, Hagström M, Kidron H, Urtti A.

Mol Pharm. 2018 Jun 4;15(6):2174-2179. doi: 10.1021/acs.molpharmaceut.8b00038. Epub 2018 May 4.

PMID:
29648838
14.

Corneal and conjunctival drug permeability: Systematic comparison and pharmacokinetic impact in the eye.

Ramsay E, Del Amo EM, Toropainen E, Tengvall-Unadike U, Ranta VP, Urtti A, Ruponen M.

Eur J Pharm Sci. 2018 Jul 1;119:83-89. doi: 10.1016/j.ejps.2018.03.034. Epub 2018 Apr 3.

PMID:
29625211
15.

Corrigendum to "Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data" [Exp. Eye Res. 137C (2015) 111-124].

Del Amo EM, Urtti A.

Exp Eye Res. 2018 Apr;169:60. doi: 10.1016/j.exer.2018.01.006. Epub 2018 Feb 3. No abstract available.

PMID:
29421329
16.

Expression, activity and pharmacokinetic impact of ocular transporters.

Vellonen KS, Hellinen L, Mannermaa E, Ruponen M, Urtti A, Kidron H.

Adv Drug Deliv Rev. 2018 Feb 15;126:3-22. doi: 10.1016/j.addr.2017.12.009. Epub 2017 Dec 14. Review.

PMID:
29248478
17.

Implications of melanin binding in ocular drug delivery.

Rimpelä AK, Reinisalo M, Hellinen L, Grazhdankin E, Kidron H, Urtti A, Del Amo EM.

Adv Drug Deliv Rev. 2018 Feb 15;126:23-43. doi: 10.1016/j.addr.2017.12.008. Epub 2017 Dec 13. Review.

PMID:
29247767
18.

Time-Resolved Fluorescence Spectroscopy Reveals Fine Structure and Dynamics of Poly(l-lysine) and Polyethylenimine Based DNA Polyplexes.

Lisitsyna ES, Ketola TM, Morin-Picardat E, Liang H, Hanzlíková M, Urtti A, Yliperttula M, Vuorimaa-Laukkanen E.

J Phys Chem B. 2017 Dec 7;121(48):10782-10792. doi: 10.1021/acs.jpcb.7b08394. Epub 2017 Nov 27.

PMID:
29116794
19.

Increased intraocular pressure alters the cellular distribution of HuR protein in retinal ganglion cells - A possible sign of endogenous neuroprotection failure.

Smedowski A, Liu X, Podracka L, Akhtar S, Trzeciecka A, Pietrucha-Dutczak M, Lewin-Kowalik J, Urtti A, Ruponen M, Kaarniranta K, Varjosalo M, Amadio M.

Biochim Biophys Acta Mol Basis Dis. 2018 Jan;1864(1):296-306. doi: 10.1016/j.bbadis.2017.10.030. Epub 2017 Oct 28.

20.

Inner Blood-Retinal Barrier Dominantly Expresses Breast Cancer Resistance Protein: Comparative Quantitative Targeted Absolute Proteomics Study of CNS Barriers in Pig.

Zhang Z, Uchida Y, Hirano S, Ando D, Kubo Y, Auriola S, Akanuma SI, Hosoya KI, Urtti A, Terasaki T, Tachikawa M.

Mol Pharm. 2017 Nov 6;14(11):3729-3738. doi: 10.1021/acs.molpharmaceut.7b00493. Epub 2017 Oct 12.

PMID:
28954515

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