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Items: 1 to 20 of 77


Efficacy and safety of a clinically relevant foamy vector design in human hematopoietic repopulating cells.

Everson EM, Hocum JD, Trobridge GD.

J Gene Med. 2018 Jun 23:e3028. doi: 10.1002/jgm.3028. [Epub ahead of print]


Rapid immune reconstitution of SCID-X1 canines after G-CSF/AMD3100 mobilization and in vivo gene therapy.

Humbert O, Chan F, Rajawat YS, Torgerson TR, Burtner CR, Hubbard NW, Humphrys D, Norgaard ZK, O'Donnell P, Adair JE, Trobridge GD, Scharenberg AM, Felsburg PJ, Rawlings DJ, Kiem HP.

Blood Adv. 2018 May 8;2(9):987-999. doi: 10.1182/bloodadvances.2018016451.


Replication-incompetent gammaretroviral and lentiviral vector-based insertional mutagenesis screens identify prostate cancer progression genes.

Bii VM, Collins CP, Hocum JD, Trobridge GD.

Oncotarget. 2018 Feb 15;9(21):15451-15463. doi: 10.18632/oncotarget.24503. eCollection 2018 Mar 20.


Insulators to Improve the Safety of Retroviral Vectors for HIV Gene Therapy.

Browning DL, Trobridge GD.

Biomedicines. 2016 Mar;4(1). pii: 4. doi: 10.3390/biomedicines4010004. Epub 2016 Feb 2.


Evidence for the in vivo safety of insulated foamy viral vectors.

Browning DL, Everson EM, Leap DJ, Hocum JD, Wang H, Stamatoyannopoulos G, Trobridge GD.

Gene Ther. 2017 Mar;24(3):187-198. doi: 10.1038/gt.2016.88. Epub 2016 Dec 26.


Retargeted Foamy Virus Vectors Integrate Less Frequently Near Proto-oncogenes.

Hocum JD, Linde I, Rae DT, Collins CP, Matern LK, Trobridge GD.

Sci Rep. 2016 Nov 4;6:36610. doi: 10.1038/srep36610.


Identifying Cancer Driver Genes Using Replication-Incompetent Retroviral Vectors.

Bii VM, Trobridge GD.

Cancers (Basel). 2016 Oct 25;8(11). pii: E99. Review.


Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.

Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem HP.

Nat Commun. 2016 Oct 20;7:13173. doi: 10.1038/ncomms13173.


A comparison of foamy and lentiviral vector genotoxicity in SCID-repopulating cells shows foamy vectors are less prone to clonal dominance.

Everson EM, Olzsko ME, Leap DJ, Hocum JD, Trobridge GD.

Mol Ther Methods Clin Dev. 2016 Aug 17;3:16048. doi: 10.1038/mtm.2016.48. eCollection 2016.


Retroviral vector interactions with hematopoietic cells.

Everson EM, Trobridge GD.

Curr Opin Virol. 2016 Dec;21:41-46. doi: 10.1016/j.coviro.2016.07.010. Epub 2016 Aug 10. Review.


Development of Third-generation Cocal Envelope Producer Cell Lines for Robust Lentiviral Gene Transfer into Hematopoietic Stem Cells and T-cells.

Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem HP.

Mol Ther. 2016 Aug;24(7):1237-46. doi: 10.1038/mt.2016.70. Epub 2016 Apr 8.


Prospects for Foamy Viral Vector Anti-HIV Gene Therapy.

Nalla AK, Trobridge GD.

Biomedicines. 2016 Mar 29;4(2). pii: E8. doi: 10.3390/biomedicines4020008. Review.


Insulated Foamy Viral Vectors.

Browning DL, Collins CP, Hocum JD, Leap DJ, Rae DT, Trobridge GD.

Hum Gene Ther. 2016 Mar;27(3):255-66. doi: 10.1089/hum.2015.110. Epub 2016 Mar 15.


Lentiviral vector-mediated insertional mutagenesis screen identifies genes that influence androgen independent prostate cancer progression and predict clinical outcome.

Nalla AK, Williams TF, Collins CP, Rae DT, Trobridge GD.

Mol Carcinog. 2016 Nov;55(11):1761-1771. doi: 10.1002/mc.22425. Epub 2015 Oct 29.


Modified Genomic Sequencing PCR Using the MiSeq Platform to Identify Retroviral Integration Sites.

Rae DT, Collins CP, Hocum JD, Browning DL, Trobridge GD.

Hum Gene Ther Methods. 2015 Dec;26(6):221-7. doi: 10.1089/hgtb.2015.060. Epub 2015 Oct 20.


A novel retroviral mutagenesis screen identifies prognostic genes in RUNX1 mediated myeloid leukemogenesis.

Rae DT, Hocum JD, Bii V, Deeg HJ, Trobridge GD.

Oncotarget. 2015 Oct 13;6(31):30664-74. doi: 10.18632/oncotarget.5133.


VISA--Vector Integration Site Analysis server: a web-based server to rapidly identify retroviral integration sites from next-generation sequencing.

Hocum JD, Battrell LR, Maynard R, Adair JE, Beard BC, Rawlings DJ, Kiem HP, Miller DG, Trobridge GD.

BMC Bioinformatics. 2015 Jul 7;16:212. doi: 10.1186/s12859-015-0653-6.


Foamy viral vector integration sites in SCID-repopulating cells after MGMTP140K-mediated in vivo selection.

Olszko ME, Adair JE, Linde I, Rae DT, Trobridge P, Hocum JD, Rawlings DJ, Kiem HP, Trobridge GD.

Gene Ther. 2015 Jul;22(7):591-5. doi: 10.1038/gt.2015.20. Epub 2015 Mar 19.


High-throughput genomic mapping of vector integration sites in gene therapy studies.

Beard BC, Adair JE, Trobridge GD, Kiem HP.

Methods Mol Biol. 2014;1185:321-44. doi: 10.1007/978-1-4939-1133-2_22.


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