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Items: 1 to 20 of 191


Mediator Undergoes a Compositional Change during Transcriptional Activation.

Petrenko N, Jin Y, Wong KH, Struhl K.

Mol Cell. 2016 Nov 3;64(3):443-454. doi: 10.1016/j.molcel.2016.09.015.


LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer.

Henry WS, Hendrickson DG, Beca F, Glass B, Lindahl-Allen M, He L, Ji Z, Struhl K, Beck AH, Rinn JL, Toker A.

Oncotarget. 2016 Dec 13;7(50):81981-81994. doi: 10.18632/oncotarget.11962.


Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers.

Miotto B, Ji Z, Struhl K.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):E4810-9. doi: 10.1073/pnas.1609060113.


Transcriptome-scale RNase-footprinting of RNA-protein complexes.

Ji Z, Song R, Huang H, Regev A, Struhl K.

Nat Biotechnol. 2016 Apr;34(4):410-3. doi: 10.1038/nbt.3441.


Many lncRNAs, 5'UTRs, and pseudogenes are translated and some are likely to express functional proteins.

Ji Z, Song R, Regev A, Struhl K.

Elife. 2015 Dec 19;4:e08890. doi: 10.7554/eLife.08890.


Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.

Rotem A, Janzer A, Izar B, Ji Z, Doench JG, Garraway LA, Struhl K.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):5708-13. doi: 10.1073/pnas.1505979112.


Mapping 3' mRNA isoforms on a genomic scale.

Jin Y, Geisberg JV, Moqtaderi Z, Ji Z, Hoque M, Tian B, Struhl K.

Curr Protoc Mol Biol. 2015 Apr 1;110:4.23.1-17. doi: 10.1002/0471142727.mb0423s110.


STAT3 acts through pre-existing nucleosome-depleted regions bound by FOS during an epigenetic switch linking inflammation to cancer.

Fleming JD, Giresi PG, Lindahl-Allen M, Krall EB, Lieb JD, Struhl K.

Epigenetics Chromatin. 2015 Feb 14;8:7. doi: 10.1186/1756-8935-8-7.


Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.

Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10574-9. doi: 10.1073/pnas.1409844111.


TFIIH phosphorylation of the Pol II CTD stimulates mediator dissociation from the preinitiation complex and promoter escape.

Wong KH, Jin Y, Struhl K.

Mol Cell. 2014 May 22;54(4):601-12. doi: 10.1016/j.molcel.2014.03.024.


Is DNA methylation of tumour suppressor genes epigenetic?

Struhl K.

Elife. 2014 Mar 12;3:e02475. doi: 10.7554/eLife.02475.


Global analysis of mRNA isoform half-lives reveals stabilizing and destabilizing elements in yeast.

Geisberg JV, Moqtaderi Z, Fan X, Ozsolak F, Struhl K.

Cell. 2014 Feb 13;156(4):812-24. doi: 10.1016/j.cell.2013.12.026.


Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts.

Moqtaderi Z, Geisberg JV, Jin Y, Fan X, Struhl K.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):11073-8. doi: 10.1073/pnas.1309384110.


NF-Y coassociates with FOS at promoters, enhancers, repetitive elements, and inactive chromatin regions, and is stereo-positioned with growth-controlling transcription factors.

Fleming JD, Pavesi G, Benatti P, Imbriano C, Mantovani R, Struhl K.

Genome Res. 2013 Aug;23(8):1195-209. doi: 10.1101/gr.148080.112.


Determinants of nucleosome positioning.

Struhl K, Segal E.

Nat Struct Mol Biol. 2013 Mar;20(3):267-73. doi: 10.1038/nsmb.2506. Review.


Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.

Hirsch HA, Iliopoulos D, Struhl K.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):972-7. doi: 10.1073/pnas.1221055110.


Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.

Yuan CC, Matthews AG, Jin Y, Chen CF, Chapman BA, Ohsumi TK, Glass KC, Kutateladze TG, Borowsky ML, Struhl K, Oettinger MA.

Cell Rep. 2012 Feb 23;1(2):83-90.


The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein.

Wong KH, Struhl K.

Genes Dev. 2011 Dec 1;25(23):2525-39. doi: 10.1101/gad.179275.111.


An HNF4α-miRNA inflammatory feedback circuit regulates hepatocellular oncogenesis.

Hatziapostolou M, Polytarchou C, Aggelidou E, Drakaki A, Poultsides GA, Jaeger SA, Ogata H, Karin M, Struhl K, Hadzopoulou-Cladaras M, Iliopoulos D.

Cell. 2011 Dec 9;147(6):1233-47. doi: 10.1016/j.cell.2011.10.043. Erratum in: Cell. 2013 Feb 28;152(5):1196.

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