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Items: 18

1.

Deficiency of sterol regulatory element-binding protein-1c induces schizophrenia-like behavior in mice.

Lee S, Kang S, Ang MJ, Kim J, Kim JC, Kim SH, Jeon TI, Jung C, Im SS, Moon C.

Genes Brain Behav. 2018 Nov 14. doi: 10.1111/gbb.12540. [Epub ahead of print]

PMID:
30430717
2.

Curcumin Activates AMPK Pathway and Regulates Lipid Metabolism in Rats Following Prolonged Clozapine Exposure.

Liu Z, Cui C, Xu P, Dang R, Cai H, Liao D, Yang M, Feng Q, Yan X, Jiang P.

Front Neurosci. 2017 Oct 4;11:558. doi: 10.3389/fnins.2017.00558. eCollection 2017.

3.

Overexpression of Insig-2 inhibits atypical antipsychotic-induced adipogenic differentiation and lipid biosynthesis in adipose-derived stem cells.

Chen CC, Hsu LW, Huang KT, Goto S, Chen CL, Nakano T.

Sci Rep. 2017 Sep 7;7(1):10901. doi: 10.1038/s41598-017-11323-9.

4.

Genetic evidence for a role of the SREBP transcription system and lipid biosynthesis in schizophrenia and antipsychotic treatment.

Steen VM, Skrede S, Polushina T, López M, Andreassen OA, Fernø J, Hellard SL.

Eur Neuropsychopharmacol. 2017 Jun;27(6):589-598. doi: 10.1016/j.euroneuro.2016.07.011. Epub 2016 Aug 1. Review.

PMID:
27492885
5.

Association between SCAP and SREBF1 gene polymorphisms and metabolic syndrome in schizophrenia patients treated with atypical antipsychotics.

Yang L, Chen J, Li Y, Wang Y, Liang S, Shi Y, Shi S, Xu Y.

World J Biol Psychiatry. 2016 Sep;17(6):467-74. doi: 10.3109/15622975.2016.1165865. Epub 2016 Apr 28.

PMID:
26982812
6.

Ameliorating antipsychotic-induced weight gain by betahistine: Mechanisms and clinical implications.

Lian J, Huang XF, Pai N, Deng C.

Pharmacol Res. 2016 Apr;106:51-63. doi: 10.1016/j.phrs.2016.02.011. Epub 2016 Feb 15. Review.

PMID:
26892184
7.

Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia.

Chen Y, Bang S, McMullen MF, Kazi H, Talbot K, Ho MX, Carlson G, Arnold SE, Ong WY, Kim SF.

Mol Neurobiol. 2017 Apr;54(3):1699-1709. doi: 10.1007/s12035-016-9773-x. Epub 2016 Feb 12.

8.

Association between SREBF2 gene polymorphisms and metabolic syndrome in clozapine-treated patients with schizophrenia.

Yang L, Chen J, Liu D, Yu S, Cong E, Li Y, Wu H, Yue Y, Zuo S, Wang Y, Liang S, Shi Y, Shi S, Xu Y.

Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:136-41. doi: 10.1016/j.pnpbp.2014.08.015. Epub 2014 Sep 6.

PMID:
25201120
9.

Pharmacogenomics of sterol synthesis and statin use in schizophrenia subjects treated with antipsychotics.

Vassas TJ, Burghardt KJ, Ellingrod VL.

Pharmacogenomics. 2014 Jan;15(1):61-7. doi: 10.2217/pgs.13.157.

10.

Lipogenic effects of psychotropic drugs: focus on the SREBP system.

Ferno J, Skrede S, Vik-Mo AO, Jassim G, Le Hellard S, Steen VM.

Front Biosci (Landmark Ed). 2011 Jan 1;16:49-60. Review.

PMID:
21196158
11.

Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol.

Kristiana I, Sharpe LJ, Catts VS, Lutze-Mann LH, Brown AJ.

Pharmacogenomics J. 2010 Oct;10(5):396-407. doi: 10.1038/tpj.2009.62. Epub 2009 Dec 8.

PMID:
19997082
12.

Psychotropic drugs up-regulate the expression of cholesterol transport proteins including ApoE in cultured human CNS- and liver cells.

Vik-Mo AO, Fernø J, Skrede S, Steen VM.

BMC Pharmacol. 2009 Aug 29;9:10. doi: 10.1186/1471-2210-9-10.

13.

Polymorphisms in SREBF1 and SREBF2, two antipsychotic-activated transcription factors controlling cellular lipogenesis, are associated with schizophrenia in German and Scandinavian samples.

Le Hellard S, Mühleisen TW, Djurovic S, Fernø J, Ouriaghi Z, Mattheisen M, Vasilescu C, Raeder MB, Hansen T, Strohmaier J, Georgi A, Brockschmidt FF, Melle I, Nenadic I, Sauer H, Rietschel M, Nöthen MM, Werge T, Andreassen OA, Cichon S, Steen VM.

Mol Psychiatry. 2010 May;15(5):463-72. doi: 10.1038/mp.2008.110. Epub 2008 Oct 21.

PMID:
18936756
14.

Association between the insulin-induced gene 2 (INSIG2) and weight gain in a German sample of antipsychotic-treated schizophrenic patients: perturbation of SREBP-controlled lipogenesis in drug-related metabolic adverse effects?

Le Hellard S, Theisen FM, Haberhausen M, Raeder MB, Fernø J, Gebhardt S, Hinney A, Remschmidt H, Krieg JC, Mehler-Wex C, Nöthen MM, Hebebrand J, Steen VM.

Mol Psychiatry. 2009 Mar;14(3):308-17. doi: 10.1038/sj.mp.4002133. Epub 2008 Jan 15.

PMID:
18195716
16.

Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells.

Raeder MB, Fernø J, Glambek M, Stansberg C, Steen VM.

Neurosci Lett. 2006 Mar 13;395(3):185-90. Epub 2005 Dec 1.

PMID:
16324787
17.

Antipsychotic drugs activate SREBP-regulated expression of lipid biosynthetic genes in cultured human glioma cells: a novel mechanism of action?

Fernø J, Raeder MB, Vik-Mo AO, Skrede S, Glambek M, Tronstad KJ, Breilid H, Løvlie R, Berge RK, Stansberg C, Steen VM.

Pharmacogenomics J. 2005;5(5):298-304.

PMID:
16027736
18.

Fatty acid regulation of gene transcription.

Jump DB.

Crit Rev Clin Lab Sci. 2004;41(1):41-78. Review.

PMID:
15077723

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