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Items: 1 to 20 of 29


Gastroprotective [6]-Gingerol Aspirinate as a Novel Chemopreventive Prodrug of Aspirin for Colon Cancer.

Zhu Y, Wang F, Zhao Y, Wang P, Sang S.

Sci Rep. 2017 Jan 9;7:40119. doi: 10.1038/srep40119.


Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches.

Zhu Y, Wang P, Sha W, Sang S.

Sci Rep. 2016 Nov 2;6:36278. doi: 10.1038/srep36278.


Ginger compound [6]-shogaol and its cysteine-conjugated metabolite (M2) activate Nrf2 in colon epithelial cells in vitro and in vivo.

Chen H, Fu J, Chen H, Hu Y, Soroka DN, Prigge JR, Schmidt EE, Yan F, Major MB, Chen X, Sang S.

Chem Res Toxicol. 2014 Sep 15;27(9):1575-85. doi: 10.1021/tx500211x. Epub 2014 Sep 2.


Cysteine-conjugated metabolites of ginger components, shogaols, induce apoptosis through oxidative stress-mediated p53 pathway in human colon cancer cells.

Fu J, Chen H, Soroka DN, Warin RF, Sang S.

J Agric Food Chem. 2014 May 21;62(20):4632-42. doi: 10.1021/jf501351r. Epub 2014 May 12.


Evaluating bioactive food components in obesity and cancer prevention.

Crowe KM, Allison D; Bioactive Food Components Conference Speakers..

Crit Rev Food Sci Nutr. 2015;55(5):732-4. doi: 10.1080/10408398.2013.878305. Review.


Induction of lung cancer cell apoptosis through a p53 pathway by [6]-shogaol and its cysteine-conjugated metabolite M2.

Warin RF, Chen H, Soroka DN, Zhu Y, Sang S.

J Agric Food Chem. 2014 Feb 12;62(6):1352-62. doi: 10.1021/jf405573e. Epub 2014 Jan 30.


[10]-Gingerdiols as the major metabolites of [10]-gingerol in zebrafish embryos and in humans and their hematopoietic effects in zebrafish embryos.

Chen H, Soroka DN, Haider J, Ferri-Lagneau KF, Leung T, Sang S.

J Agric Food Chem. 2013 Jun 5;61(22):5353-60. doi: 10.1021/jf401501s. Epub 2013 May 23.


Cysteine-conjugated metabolite of ginger component [6]-shogaol serves as a carrier of [6]-shogaol in cancer cells and in mice.

Chen H, Soroka DN, Zhu Y, Hu Y, Chen X, Sang S.

Chem Res Toxicol. 2013 Jun 17;26(6):976-85. doi: 10.1021/tx4001286. Epub 2013 May 15.


Metabolites of ginger component [6]-shogaol remain bioactive in cancer cells and have low toxicity in normal cells: chemical synthesis and biological evaluation.

Zhu Y, Warin RF, Soroka DN, Chen H, Sang S.

PLoS One. 2013;8(1):e54677. doi: 10.1371/journal.pone.0054677. Epub 2013 Jan 30.


Metabolism of ginger component [6]-shogaol in liver microsomes from mouse, rat, dog, monkey, and human.

Chen H, Soroka D, Zhu Y, Sang S.

Mol Nutr Food Res. 2013 May;57(5):865-76. doi: 10.1002/mnfr.201200708. Epub 2013 Jan 16.


Characterization of thiol-conjugated metabolites of ginger components shogaols in mouse and human urine and modulation of the glutathione levels in cancer cells by [6]-shogaol.

Chen H, Soroka DN, Hu Y, Chen X, Sang S.

Mol Nutr Food Res. 2013 Mar;57(3):447-58. doi: 10.1002/mnfr.201200679. Epub 2013 Jan 16.


The microbiota is essential for the generation of black tea theaflavins-derived metabolites.

Chen H, Hayek S, Rivera Guzman J, Gillitt ND, Ibrahim SA, Jobin C, Sang S.

PLoS One. 2012;7(12):e51001. doi: 10.1371/journal.pone.0051001. Epub 2012 Dec 5.


Chemoprevention of 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster cheek pouch carcinogenesis by a 5-lipoxygenase inhibitor, garcinol.

Chen X, Zhang X, Lu Y, Shim JY, Sang S, Sun Z, Chen X.

Nutr Cancer. 2012;64(8):1211-8. doi: 10.1080/01635581.2012.718032. Epub 2012 Nov 8.


6-gingerdiols as the major metabolites of 6-gingerol in cancer cells and in mice and their cytotoxic effects on human cancer cells.

Lv L, Chen H, Soroka D, Chen X, Leung T, Sang S.

J Agric Food Chem. 2012 Nov 14;60(45):11372-7. doi: 10.1021/jf303879b. Epub 2012 Nov 6.


Identification of phase II metabolites of thiol-conjugated [6]-shogaol in mouse urine using high-performance liquid chromatography tandem mass spectrometry.

Chen H, Sang S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Oct 15;907:126-39. doi: 10.1016/j.jchromb.2012.09.020. Epub 2012 Sep 18.


Ginger stimulates hematopoiesis via Bmp pathway in zebrafish.

Ferri-Lagneau KF, Moshal KS, Grimes M, Zahora B, Lv L, Sang S, Leung T.

PLoS One. 2012;7(6):e39327. doi: 10.1371/journal.pone.0039327. Epub 2012 Jun 25.


Metabolism of [6]-shogaol in mice and in cancer cells.

Chen H, Lv L, Soroka D, Warin RF, Parks TA, Hu Y, Zhu Y, Chen X, Sang S.

Drug Metab Dispos. 2012 Apr;40(4):742-53. doi: 10.1124/dmd.111.043331. Epub 2012 Jan 13.


Structural identification of mouse fecal metabolites of theaflavin 3,3'-digallate using liquid chromatography tandem mass spectrometry.

Chen H, Parks TA, Chen X, Gillitt ND, Jobin C, Sang S.

J Chromatogr A. 2011 Oct 14;1218(41):7297-306. doi: 10.1016/j.chroma.2011.08.056. Epub 2011 Aug 25.


Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection.

Shao X, Lv L, Parks T, Wu H, Ho CT, Sang S.

J Agric Food Chem. 2010 Dec 22;58(24):12608-14. doi: 10.1021/jf1029256. Epub 2010 Nov 23.


Anticancer and anti-inflammatory effects of cysteine metabolites of the green tea polyphenol, (-)-epigallocatechin-3-gallate.

Lambert JD, Sang S, Hong J, Yang CS.

J Agric Food Chem. 2010 Sep 22;58(18):10016-9. doi: 10.1021/jf102311t.

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