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A Network Explanation of Alzheimer's Regional Vulnerability.

Small SA, Swanson LW.

Cold Spring Harb Symp Quant Biol. 2019 Jan 14. pii: 036889. doi: 10.1101/sqb.2018.83.036889. [Epub ahead of print]


An Alzheimer's Disease-Linked Loss-of-Function CLN5 Variant Impairs Cathepsin D Maturation, Consistent with a Retromer Trafficking Defect.

Qureshi YH, Patel VM, Berman DE, Kothiya MJ, Neufeld JL, Vardarajan B, Tang M, Reyes-Dumeyer D, Lantigua R, Medrano M, Jiménez-Velázquez IJ, Small SA, Reitz C.

Mol Cell Biol. 2018 Sep 28;38(20). pii: e00011-18. doi: 10.1128/MCB.00011-18. Print 2018 Oct 15.


Cholera toxin inhibits SNX27-retromer-mediated delivery of cargo proteins to the plasma membrane.

Singh V, Yang J, Yin J, Cole R, Tse M, Berman DE, Small SA, Petsko G, Donowitz M.

J Cell Sci. 2018 Aug 17;131(16). pii: jcs218610. doi: 10.1242/jcs.218610.


Temporal lobe epilepsy lateralization using retrospective cerebral blood volume MRI.

Feng X, Hamberger MJ, Sigmon HC, Guo J, Small SA, Provenzano FA.

Neuroimage Clin. 2018 May 10;19:911-917. doi: 10.1016/j.nicl.2018.05.012. eCollection 2018.


Stabilizing the Retromer Complex in a Human Stem Cell Model of Alzheimer's Disease Reduces TAU Phosphorylation Independently of Amyloid Precursor Protein.

Young JE, Fong LK, Frankowski H, Petsko GA, Small SA, Goldstein LSB.

Stem Cell Reports. 2018 Mar 13;10(3):1046-1058. doi: 10.1016/j.stemcr.2018.01.031. Epub 2018 Mar 1.


Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction.

Lander SS, Khan U, Lewandowski N, Chakraborty D, Provenzano FA, Mingote S, Chornyy S, Frigerio F, Maechler P, Kaphzan H, Small SA, Rayport S, Gaisler-Salomon I.

Schizophr Bull. 2019 Jan 1;45(1):127-137. doi: 10.1093/schbul/sby011.


Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures.

Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G.

Nat Commun. 2018 Jan 18;9(1):291. doi: 10.1038/s41467-017-02533-w.


Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology.

Nuriel T, Angulo SL, Khan U, Ashok A, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE.

Nat Commun. 2017 Nov 13;8(1):1464. doi: 10.1038/s41467-017-01444-0.


In vivo detection and automatic analysis of GABA in the mouse brain with MEGA-PRESS at 9.4 T.

Guo J, Gang Z, Sun Y, Laine A, Small SA, Rothman DL.

NMR Biomed. 2018 Jan;31(1). doi: 10.1002/nbm.3837. Epub 2017 Nov 3.


Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease.

Small SA, Simoes-Spassov S, Mayeux R, Petsko GA.

Trends Neurosci. 2017 Oct;40(10):592-602. doi: 10.1016/j.tins.2017.08.003. Review.


The ModRey: An Episodic Memory Test for Nonclinical and Preclinical Populations.

Hale C, Last BS, Meier IB, Yeung LK, Budge M, Sloan RP, Small SA, Brickman AM.

Assessment. 2017 Aug 1:1073191117723113. doi: 10.1177/1073191117723113. [Epub ahead of print]


Retromer in Alzheimer disease, Parkinson disease and other neurological disorders.

Small SA, Petsko GA.

Nat Rev Neurosci. 2015 Mar;16(3):126-32. doi: 10.1038/nrn3896. Epub 2015 Feb 11. Review.


Anhedonia in the psychosis risk syndrome: associations with social impairment and basal orbitofrontal cortical activity.

Cressman VL, Schobel SA, Steinfeld S, Ben-David S, Thompson JL, Small SA, Moore H, Corcoran CM.

NPJ Schizophr. 2015 Jul 15;1:15020. doi: 10.1038/npjschz.2015.20. eCollection 2015.


The use of pharmacological retromer chaperones in Alzheimer's disease and other endosomal-related disorders.

Berman DE, Ringe D, Petsko GA, Small SA.

Neurotherapeutics. 2015 Jan;12(1):12-8. doi: 10.1007/s13311-014-0321-y. Review.


Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults.

Brickman AM, Khan UA, Provenzano FA, Yeung LK, Suzuki W, Schroeter H, Wall M, Sloan RP, Small SA.

Nat Neurosci. 2014 Dec;17(12):1798-803. doi: 10.1038/nn.3850. Epub 2014 Oct 26.


Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability.

Small SA.

Neuron. 2014 Oct 1;84(1):32-39. doi: 10.1016/j.neuron.2014.08.030. Review.


Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals.

Barral S, Reitz C, Small SA, Mayeux R.

Neurobiol Aging. 2014 Dec;35(12):2881.e7-2881.e10. doi: 10.1016/j.neurobiolaging.2014.06.024. Epub 2014 Jun 28.


Pharmacological chaperones in the age of proteomic pathology.

Small SA.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12274-5. doi: 10.1073/pnas.1413111111. Epub 2014 Aug 13. No abstract available.


Interneuron precursor transplants in adult hippocampus reverse psychosis-relevant features in a mouse model of hippocampal disinhibition.

Gilani AI, Chohan MO, Inan M, Schobel SA, Chaudhury NH, Paskewitz S, Chuhma N, Glickstein S, Merker RJ, Xu Q, Small SA, Anderson SA, Ross ME, Moore H.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7450-5. doi: 10.1073/pnas.1316488111. Epub 2014 May 2.


Pharmacological chaperones stabilize retromer to limit APP processing.

Mecozzi VJ, Berman DE, Simoes S, Vetanovetz C, Awal MR, Patel VM, Schneider RT, Petsko GA, Ringe D, Small SA.

Nat Chem Biol. 2014 Jun;10(6):443-9. doi: 10.1038/nchembio.1508. Epub 2014 Apr 20.

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