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Items: 1 to 20 of 48

1.

Mitochondrial DNA is critical for longevity and metabolism of transmission stage Trypanosoma brucei.

Dewar CE, MacGregor P, Cooper S, Gould MK, Matthews KR, Savill NJ, Schnaufer A.

PLoS Pathog. 2018 Jul 18;14(7):e1007195. doi: 10.1371/journal.ppat.1007195. eCollection 2018 Jul.

2.

Pharmacological inhibition of the vacuolar ATPase in bloodstream form Trypanosoma brucei rescues genetic knockdown of mitochondrial gene expression.

Schaffner-Barbero C, Miskinyte M, Grewal JS, Schnaufer A.

Antimicrob Agents Chemother. 2018 Jun 18. pii: AAC.02268-17. doi: 10.1128/AAC.02268-17. [Epub ahead of print]

3.

Multiple evolutionary origins of Trypanosoma evansi in Kenya.

Kamidi CM, Saarman NP, Dion K, Mireji PO, Ouma C, Murilla G, Aksoy S, Schnaufer A, Caccone A.

PLoS Negl Trop Dis. 2017 Sep 7;11(9):e0005895. doi: 10.1371/journal.pntd.0005895. eCollection 2017 Sep.

4.

In situ structure of trypanosomal ATP synthase dimer reveals a unique arrangement of catalytic subunits.

Mühleip AW, Dewar CE, Schnaufer A, Kühlbrandt W, Davies KM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):992-997. doi: 10.1073/pnas.1612386114. Epub 2017 Jan 17.

5.

NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms.

Surve SV, Jensen BC, Heestand M, Mazet M, Smith TK, Bringaud F, Parsons M, Schnaufer A.

Mol Biochem Parasitol. 2017 Jan;211:57-61. doi: 10.1016/j.molbiopara.2016.10.001. Epub 2016 Oct 4.

6.

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase.

Eze AA, Gould MK, Munday JC, Tagoe DN, Stelmanis V, Schnaufer A, De Koning HP.

PLoS Negl Trop Dis. 2016 Aug 12;10(8):e0004791. doi: 10.1371/journal.pntd.0004791. eCollection 2016 Aug.

7.

Correction: TAC102 Is a Novel Component of the Mitochondrial Genome Segregation Machinery in Trypanosomes.

Trikin R, Doiron N, Hoffmann A, Haenni B, Jakob M, Schnaufer A, Schimanski B, Zuber B, Ochsenreiter T.

PLoS Pathog. 2016 Jul 1;12(7):e1005750. doi: 10.1371/journal.ppat.1005750. eCollection 2016 Jul.

8.

TAC102 Is a Novel Component of the Mitochondrial Genome Segregation Machinery in Trypanosomes.

Trikin R, Doiron N, Hoffmann A, Haenni B, Jakob M, Schnaufer A, Schimanski B, Zuber B, Ochsenreiter T.

PLoS Pathog. 2016 May 11;12(5):e1005586. doi: 10.1371/journal.ppat.1005586. eCollection 2016 May. Erratum in: PLoS Pathog. 2016 Jul;12(7):e1005750.

9.

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection.

Cuypers B, Lecordier L, Meehan CJ, Van den Broeck F, Imamura H, Büscher P, Dujardin JC, Laukens K, Schnaufer A, Dewar C, Lewis M, Balmer O, Azurago T, Kyei-Faried S, Ohene SA, Duah B, Homiah P, Mensah EK, Anleah F, Franco JR, Pays E, Deborggraeve S.

MBio. 2016 Apr 12;7(2):e02198-15. doi: 10.1128/mBio.02198-15.

10.

PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast.

Grewal JS, McLuskey K, Das D, Myburgh E, Wilkes J, Brown E, Lemgruber L, Gould MK, Burchmore RJ, Coombs GH, Schnaufer A, Mottram JC.

J Biol Chem. 2016 Apr 29;291(18):9492-500. doi: 10.1074/jbc.M116.714972. Epub 2016 Mar 3.

11.

A novel high-throughput activity assay for the Trypanosoma brucei editosome enzyme REL1 and other RNA ligases.

Zimmermann S, Hall L, Riley S, Sørensen J, Amaro RE, Schnaufer A.

Nucleic Acids Res. 2016 Feb 18;44(3):e24. doi: 10.1093/nar/gkv938. Epub 2015 Sep 22.

12.

Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty.

Carnes J, Anupama A, Balmer O, Jackson A, Lewis M, Brown R, Cestari I, Desquesnes M, Gendrin C, Hertz-Fowler C, Imamura H, Ivens A, Kořený L, Lai DH, MacLeod A, McDermott SM, Merritt C, Monnerat S, Moon W, Myler P, Phan I, Ramasamy G, Sivam D, Lun ZR, Lukeš J, Stuart K, Schnaufer A.

PLoS Negl Trop Dis. 2015 Jan 8;9(1):e3404. doi: 10.1371/journal.pntd.0003404. eCollection 2015 Jan.

13.

Trypanosomal TAC40 constitutes a novel subclass of mitochondrial β-barrel proteins specialized in mitochondrial genome inheritance.

Schnarwiler F, Niemann M, Doiron N, Harsman A, Käser S, Mani J, Chanfon A, Dewar CE, Oeljeklaus S, Jackson CB, Pusnik M, Schmidt O, Meisinger C, Hiller S, Warscheid B, Schnaufer AC, Ochsenreiter T, Schneider A.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7624-9. doi: 10.1073/pnas.1404854111. Epub 2014 May 12.

14.

Independence from Kinetoplast DNA maintenance and expression is associated with multidrug resistance in Trypanosoma brucei in vitro.

Gould MK, Schnaufer A.

Antimicrob Agents Chemother. 2014 May;58(5):2925-8. doi: 10.1128/AAC.00122-14. Epub 2014 Feb 18.

15.

Single point mutations in ATP synthase compensate for mitochondrial genome loss in trypanosomes.

Dean S, Gould MK, Dewar CE, Schnaufer AC.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14741-6. doi: 10.1073/pnas.1305404110. Epub 2013 Aug 19.

16.

Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA.

Gould MK, Bachmaier S, Ali JA, Alsford S, Tagoe DN, Munday JC, Schnaufer AC, Horn D, Boshart M, de Koning HP.

Antimicrob Agents Chemother. 2013 Oct;57(10):4882-93. doi: 10.1128/AAC.00508-13. Epub 2013 Jul 22.

17.

Trypanosoma brucei 14-3-3I and II proteins predominantly form a heterodimer structure that acts as a potent cell cycle regulator in vivo.

Inoue M, Yasuda K, Uemura H, Yasaka N, Schnaufer A, Yano M, Kido H, Kohda D, Doi H, Fukuma T, Tsuji A, Horikoshi N.

J Biochem. 2013 May;153(5):431-9. doi: 10.1093/jb/mvt016. Epub 2013 Mar 1.

PMID:
23457405
18.

Mutational analysis of Trypanosoma brucei editosome proteins KREPB4 and KREPB5 reveals domains critical for function.

Carnes J, Schnaufer A, McDermott SM, Domingo G, Proff R, Steinberg AG, Kurtz I, Stuart K.

RNA. 2012 Oct;18(10):1897-909. doi: 10.1261/rna.035048.112. Epub 2012 Aug 23.

19.

Editosome accessory factors KREPB9 and KREPB10 in Trypanosoma brucei.

Lerch M, Carnes J, Acestor N, Guo X, Schnaufer A, Stuart K.

Eukaryot Cell. 2012 Jul;11(7):832-43. doi: 10.1128/EC.00046-12. Epub 2012 May 4.

20.

Enigmatic presence of mitochondrial complex I in Trypanosoma brucei bloodstream forms.

Surve S, Heestand M, Panicucci B, Schnaufer A, Parsons M.

Eukaryot Cell. 2012 Feb;11(2):183-93. doi: 10.1128/EC.05282-11. Epub 2011 Dec 9.

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