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Items: 1 to 20 of 251

1.

Characterization of the antinociceptive effects of intrathecal DALDA peptides following bolus intrathecal delivery.

Kokubu S, Eddinger KA, Nguyen TM, Huerta-Esquivel LL, Yamaguchi S, Schiller PW, Yaksh TL.

Scand J Pain. 2018 Oct 25. pii: /j/sjpain.ahead-of-print/sjpain-2018-0120/sjpain-2018-0120.xml. doi: 10.1515/sjpain-2018-0120. [Epub ahead of print]

PMID:
30367811
2.

Strengthening peptide-based drug activity with novel glyconanoparticle.

Lewicky JD, Martel AL, Fraleigh NL, Boraman A, Nguyen TM, Schiller PW, Shiao TC, Roy R, Le HT.

PLoS One. 2018 Sep 27;13(9):e0204472. doi: 10.1371/journal.pone.0204472. eCollection 2018.

3.

Corrigendum to "Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings" [Bioorg. Med. Chem. Lett. 28(13) (2018) 2320-2323].

Willemse T, Eiselt E, Hollanders K, Schepens W, van Vlijmen HWT, Chung NN, Blais V, Holleran B, Longpré JM, Schiller PW, Maes BUW, Sarret P, Gendron L, Ballet S.

Bioorg Med Chem Lett. 2018 Nov 1;28(20):3418. doi: 10.1016/j.bmcl.2018.08.023. Epub 2018 Sep 5. No abstract available.

PMID:
30195888
4.

Chemical space screening around Phe3 in opioid peptides: Modulating µ versus δ agonism by Suzuki-Miyaura cross-couplings.

Willemse T, Eiselt E, Hollanders K, Schepens W, van Vlijmen HWT, Chung NN, Blais V, Holleran B, Longpré JM, Schiller PW, Maes BUW, Sarret P, Gendron L, Ballet S.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2320-2323. doi: 10.1016/j.bmcl.2018.05.015. Epub 2018 May 12. Erratum in: Bioorg Med Chem Lett. 2018 Nov 1;28(20):3418.

5.

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action.

Stoeber M, Jullié D, Lobingier BT, Laeremans T, Steyaert J, Schiller PW, Manglik A, von Zastrow M.

Neuron. 2018 Jun 6;98(5):963-976.e5. doi: 10.1016/j.neuron.2018.04.021. Epub 2018 May 10.

PMID:
29754753
6.

Protective Effect of a Mitochondria-Targeted Peptide against the Development of Chemotherapy-Induced Peripheral Neuropathy in Mice.

Toyama S, Shimoyama N, Szeto HH, Schiller PW, Shimoyama M.

ACS Chem Neurosci. 2018 Jul 18;9(7):1566-1571. doi: 10.1021/acschemneuro.8b00013. Epub 2018 Apr 18.

7.

χ-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds.

Van der Poorten O, Van Den Hauwe R, Eiselt E, Betti C, Guillemyn K, Chung NN, Hallé F, Bihel F, Schiller PW, Tourwé D, Sarret P, Gendron L, Ballet S.

ACS Med Chem Lett. 2017 Oct 4;8(11):1177-1182. doi: 10.1021/acsmedchemlett.7b00347. eCollection 2017 Nov 9.

8.

Analgesic Properties of Opioid/NK1 Multitarget Ligands with Distinct in Vitro Profiles in Naive and Chronic Constriction Injury Mice.

Starnowska J, Costante R, Guillemyn K, Popiolek-Barczyk K, Chung NN, Lemieux C, Keresztes A, Van Duppen J, Mollica A, Streicher J, Vanden Broeck J, Schiller PW, Tourwé D, Mika J, Ballet S, Przewlocka B.

ACS Chem Neurosci. 2017 Oct 18;8(10):2315-2324. doi: 10.1021/acschemneuro.7b00226. Epub 2017 Jul 26.

9.

A Cyclic Tetrapeptide ("Cyclodal") and Its Mirror-Image Isomer Are Both High-Affinity μ Opioid Receptor Antagonists.

Weltrowska G, Nguyen TM, Chung NN, Wood J, Ma X, Guo J, Wilkes BC, Ge Y, Laferrière A, Coderre TJ, Schiller PW.

J Med Chem. 2016 Oct 13;59(19):9243-9254. doi: 10.1021/acs.jmedchem.6b01200. Epub 2016 Oct 3.

10.

Prorenin/renin receptor blockade promotes a healthy fat distribution in obese mice.

Tan P, Blais C, Nguyen TM, Schiller PW, Gutkowska J, Lavoie JL.

Obesity (Silver Spring). 2016 Sep;24(9):1946-54. doi: 10.1002/oby.21592. Epub 2016 Jul 26.

11.

Molecular Pharmacology of δ-Opioid Receptors.

Gendron L, Cahill CM, von Zastrow M, Schiller PW, Pineyro G.

Pharmacol Rev. 2016 Jul;68(3):631-700. doi: 10.1124/pr.114.008979. Review.

12.

[Dmt(1)]DALDA analogues modified with tyrosine analogues at position 1.

Cai Y, Lu D, Chen Z, Ding Y, Chung NN, Li T, Schiller PW.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3629-31. doi: 10.1016/j.bmcl.2016.06.003. Epub 2016 Jun 3.

13.

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.

Guillemyn K, Starnowska J, Lagard C, Dyniewicz J, Rojewska E, Mika J, Chung NN, Utard V, Kosson P, Lipkowski AW, Chevillard L, Arranz-Gibert P, Teixidó M, Megarbane B, Tourwé D, Simonin F, Przewlocka B, Schiller PW, Ballet S.

J Med Chem. 2016 Apr 28;59(8):3777-92. doi: 10.1021/acs.jmedchem.5b01976. Epub 2016 Apr 14.

14.

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics.

Betti C, Starnowska J, Mika J, Dyniewicz J, Frankiewicz L, Novoa A, Bochynska M, Keresztes A, Kosson P, Makuch W, Van Duppen J, Chung NN, Vanden Broeck J, Lipkowski AW, Schiller PW, Janssens F, Ceusters M, Sommen F, Meert T, Przewlocka B, Tourwé D, Ballet S.

ACS Med Chem Lett. 2015 Oct 31;6(12):1209-14. doi: 10.1021/acsmedchemlett.5b00359. eCollection 2015 Dec 10.

15.

The bifunctional μ opioid agonist/antioxidant [Dmt(1)]DALDA is a superior analgesic in an animal model of complex regional pain syndrome-type i.

Schiller PW, Nguyen TM, Saray A, Poon AW, Laferrière A, Coderre TJ.

ACS Chem Neurosci. 2015 Nov 18;6(11):1789-93. doi: 10.1021/acschemneuro.5b00228. Epub 2015 Sep 14.

16.

Structural basis for bifunctional peptide recognition at human δ-opioid receptor.

Fenalti G, Zatsepin NA, Betti C, Giguere P, Han GW, Ishchenko A, Liu W, Guillemyn K, Zhang H, James D, Wang D, Weierstall U, Spence JC, Boutet S, Messerschmidt M, Williams GJ, Gati C, Yefanov OM, White TA, Oberthuer D, Metz M, Yoon CH, Barty A, Chapman HN, Basu S, Coe J, Conrad CE, Fromme R, Fromme P, Tourwé D, Schiller PW, Roth BL, Ballet S, Katritch V, Stevens RC, Cherezov V.

Nat Struct Mol Biol. 2015 Mar;22(3):265-8. doi: 10.1038/nsmb.2965. Epub 2015 Feb 16.

17.

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.

Guillemyn K, Kleczkowska P, Lesniak A, Dyniewicz J, Van der Poorten O, Van den Eynde I, Keresztes A, Varga E, Lai J, Porreca F, Chung NN, Lemieux C, Mika J, Rojewska E, Makuch W, Van Duppen J, Przewlocka B, Vanden Broeck J, Lipkowski AW, Schiller PW, Tourwé D, Ballet S.

Eur J Med Chem. 2015 Mar 6;92:64-77. doi: 10.1016/j.ejmech.2014.12.033. Epub 2014 Dec 19.

18.

'Carba'-carfentanil (trans isomer): a μ opioid receptor (MOR) partial agonist with a distinct binding mode.

Weltrowska G, Lemieux C, Chung NN, Guo JJ, Wilkes BC, Schiller PW.

Bioorg Med Chem. 2014 Sep 1;22(17):4581-6. doi: 10.1016/j.bmc.2014.07.033. Epub 2014 Jul 29.

19.

Impact of the prorenin/renin receptor on the development of obesity and associated cardiometabolic risk factors.

Tan P, Shamansurova Z, Bisotto S, Michel C, Gauthier MS, Rabasa-Lhoret R, Nguyen TM, Schiller PW, Gutkowska J, Lavoie JL.

Obesity (Silver Spring). 2014 Oct;22(10):2201-9. doi: 10.1002/oby.20844. Epub 2014 Jul 10.

20.

One-pot isomerization-cross metathesis-reduction (ICMR) synthesis of lipophilic tetrapeptides.

Jida M, Betti C, Schiller PW, Tourwé D, Ballet S.

ACS Comb Sci. 2014 Jul 14;16(7):342-51. doi: 10.1021/co500020a. Epub 2014 Jun 18.

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