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Items: 1 to 20 of 95


The Frequency Response of Outer Hair Cell Voltage-Dependent Motility Is Limited by Kinetics of Prestin.

Santos-Sacchi J, Tan W.

J Neurosci. 2018 Jun 13;38(24):5495-5506. doi: 10.1523/JNEUROSCI.0425-18.2018. Epub 2018 May 21.


Current carried by the Slc26 family member prestin does not flow through the transporter pathway.

Bai JP, Moeini-Naghani I, Zhong S, Li FY, Bian S, Sigworth FJ, Santos-Sacchi J, Navaratnam D.

Sci Rep. 2017 Apr 19;7:46619. doi: 10.1038/srep46619.


Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear.

Tan WJT, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough WG, Santos-Sacchi J, Ivanova AV.

Antioxid Redox Signal. 2017 Sep 10;27(8):489-509. doi: 10.1089/ars.2016.6851. Epub 2017 Mar 9.


Synaptic Ribbons Require Ribeye for Electron Density, Proper Synaptic Localization, and Recruitment of Calcium Channels.

Lv C, Stewart WJ, Akanyeti O, Frederick C, Zhu J, Santos-Sacchi J, Sheets L, Liao JC, Zenisek D.

Cell Rep. 2016 Jun 21;15(12):2784-95. doi: 10.1016/j.celrep.2016.05.045. Epub 2016 Jun 9.


Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5.

Santos-Sacchi J, Song L.

Biophys J. 2016 Jun 7;110(11):2551-2561. doi: 10.1016/j.bpj.2016.05.002.


A Walkthrough of Nonlinear Capacitance Measurement of Outer Hair Cells.

Song L, Santos-Sacchi J.

Methods Mol Biol. 2016;1427:501-12. doi: 10.1007/978-1-4939-3615-1_28.


Auditory Pathology in a Transgenic mtTFB1 Mouse Model of Mitochondrial Deafness.

McKay SE, Yan W, Nouws J, Thormann MJ, Raimundo N, Khan A, Santos-Sacchi J, Song L, Shadel GS.

Am J Pathol. 2015 Dec;185(12):3132-40. doi: 10.1016/j.ajpath.2015.08.014. Epub 2015 Nov 6.


An electrical inspection of the subsurface cisternae of the outer hair cell.

Song L, Santos-Sacchi J.

Biophys J. 2015 Feb 3;108(3):568-77. doi: 10.1016/j.bpj.2014.12.010.


Tyrosine motifs are required for prestin basolateral membrane targeting.

Zhang Y, Moeini-Naghani I, Bai J, Santos-Sacchi J, Navaratnam DS.

Biol Open. 2015 Jan 16;4(2):197-205. doi: 10.1242/bio.201410629.


Chloride-driven electromechanical phase lags at acoustic frequencies are generated by SLC26a5, the outer hair cell motor protein.

Santos-Sacchi J, Song L.

Biophys J. 2014 Jul 1;107(1):126-33. doi: 10.1016/j.bpj.2014.05.018.


Chloride and salicylate influence prestin-dependent specific membrane capacitance: support for the area motor model.

Santos-Sacchi J, Song L.

J Biol Chem. 2014 Apr 11;289(15):10823-30. doi: 10.1074/jbc.M114.549329. Epub 2014 Feb 19.


IR laser-induced perturbations of the voltage-dependent solute carrier protein SLC26a5.

Okunade O, Santos-Sacchi J.

Biophys J. 2013 Oct 15;105(8):1822-8. doi: 10.1016/j.bpj.2013.09.008.


Real time measures of prestin charge and fluorescence during plasma membrane trafficking reveal sub-tetrameric activity.

Bian S, Navaratnam D, Santos-Sacchi J.

PLoS One. 2013 Jun 10;8(6):e66078. doi: 10.1371/journal.pone.0066078. Print 2013.


Disparities in voltage-sensor charge and electromotility imply slow chloride-driven state transitions in the solute carrier SLC26a5.

Song L, Santos-Sacchi J.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3883-8. doi: 10.1073/pnas.1218341110. Epub 2013 Feb 19.


Patch-clamp recordings from lateral line neuromast hair cells of the living zebrafish.

Ricci AJ, Bai JP, Song L, Lv C, Zenisek D, Santos-Sacchi J.

J Neurosci. 2013 Feb 13;33(7):3131-4. doi: 10.1523/JNEUROSCI.4265-12.2013.


Tracking vesicle fusion from hair cell ribbon synapses using a high frequency, dual sine wave stimulus paradigm.

Schnee ME, Castellano-Muñoz M, Kong JH, Santos-Sacchi J, Ricci AJ.

Commun Integr Biol. 2011 Nov 1;4(6):785-7.


Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.

Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS.

Cell. 2012 Feb 17;148(4):716-26. doi: 10.1016/j.cell.2011.12.027.


Extracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells.

Li X, Surguchev A, Bian S, Navaratnam D, Santos-Sacchi J.

Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C296-306. doi: 10.1152/ajpcell.00177.2011. Epub 2011 Sep 21.


Calcium-dependent synaptic vesicle trafficking underlies indefatigable release at the hair cell afferent fiber synapse.

Schnee ME, Santos-Sacchi J, Castellano-Muñoz M, Kong JH, Ricci AJ.

Neuron. 2011 Apr 28;70(2):326-38. doi: 10.1016/j.neuron.2011.01.031.

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