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Items: 1 to 20 of 111


A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine.

Chaim IA, Gardner A, Wu J, Iyama T, Wilson DM 3rd, Samson LD.

Nucleic Acids Res. 2017 Jan 23. pii: gkx015. doi: 10.1093/nar/gkx015. [Epub ahead of print]


Base Excision Repair of N6-Deoxyadenosine Adducts of 1,3-Butadiene.

Wickramaratne S, Banda DM, Ji S, Manlove AH, Malayappan B, Nuñez NN, Samson L, Campbell C, David SS, Tretyakova N.

Biochemistry. 2016 Nov 1;55(43):6070-6081.


DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.

Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD.

Cancer Res. 2017 Jan 1;77(1):198-206. doi: 10.1158/0008-5472.CAN-16-1151.


Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner.

Calvo JA, Allocca M, Fake KR, Muthupalani S, Corrigan JJ, Bronson RT, Samson LD.

Oncotarget. 2016 Jul 19;7(29):44950-44965. doi: 10.18632/oncotarget.10440.


The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.

Yu AM, Calvo JA, Muthupalani S, Samson LD.

Oncotarget. 2016 May 10;7(19):28624-36. doi: 10.18632/oncotarget.8721.


Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response.

Beharry AA, Nagel ZD, Samson LD, Kool ET.

PLoS One. 2016 Apr 1;11(4):e0152684. doi: 10.1371/journal.pone.0152684.


Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616.


Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney.

Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C, Samson LD.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4878-86. doi: 10.1073/pnas.1413582111.


DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo.

Kiraly O, Gong G, Roytman MD, Yamada Y, Samson LD, Engelward BP.

Carcinogenesis. 2014 Nov;35(11):2495-502. doi: 10.1093/carcin/bgu177.


Repair of endogenous DNA base lesions modulate lifespan in mice.

Meira LB, Calvo JA, Shah D, Klapacz J, Moroski-Erkul CA, Bronson RT, Samson LD.

DNA Repair (Amst). 2014 Sep;21:78-86. doi: 10.1016/j.dnarep.2014.05.012.


Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research.

Nagel ZD, Chaim IA, Samson LD.

DNA Repair (Amst). 2014 Jul;19:199-213. doi: 10.1016/j.dnarep.2014.03.009.


Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.

Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1823-32. doi: 10.1073/pnas.1401182111.


Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae.

Mazumder A, Pesudo LQ, McRee S, Bathe M, Samson LD.

Nucleic Acids Res. 2013 Nov;41(20):9310-24. doi: 10.1093/nar/gkt715.


Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis.

Fu D, Jordan JJ, Samson LD.

Genes Dev. 2013 May 15;27(10):1089-100. doi: 10.1101/gad.215533.113.


Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae.

Vahey MD, Quiros Pesudo L, Svensson JP, Samson LD, Voldman J.

Lab Chip. 2013 Jul 21;13(14):2754-63. doi: 10.1039/c3lc50162k.


Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1.

Calvo JA, Moroski-Erkul CA, Lake A, Eichinger LW, Shah D, Jhun I, Limsirichai P, Bronson RT, Christiani DC, Meira LB, Samson LD.

PLoS Genet. 2013 Apr;9(4):e1003413. doi: 10.1371/journal.pgen.1003413.


Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).

van Loon B, Samson LD.

DNA Repair (Amst). 2013 Mar 1;12(3):177-87. doi: 10.1016/j.dnarep.2012.11.009.


Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage.

Mazumder A, Tummler K, Bathe M, Samson LD.

Mol Cell Biol. 2013 Feb;33(3):635-42. doi: 10.1128/MCB.01020-12.

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