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Items: 1 to 20 of 71


HnRNPA2 is a novel histone acetyltransferase that mediates mitochondrial stress-induced nuclear gene expression.

Guha M, Srinivasan S, Guja K, Mejia E, Garcia-Diaz M, Johnson FB, Ruthel G, Kaufman BA, Rappaport EF, Glineburg MR, Fang JK, Szanto AK, Nakagawa H, Basha J, Kundu T, Avadhani NG.

Cell Discov. 2016 Dec 6;2:16045. eCollection 2016.


Redefining the Chronic-Wound Microbiome: Fungal Communities Are Prevalent, Dynamic, and Associated with Delayed Healing.

Kalan L, Loesche M, Hodkinson BP, Heilmann K, Ruthel G, Gardner SE, Grice EA.

MBio. 2016 Sep 6;7(5). pii: e01058-16. doi: 10.1128/mBio.01058-16.


Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress.

Loughran HM, Han Z, Wrobel JE, Decker SE, Ruthel G, Freedman BD, Harty RN, Reitz AB.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3429-35. doi: 10.1016/j.bmcl.2016.06.053. Epub 2016 Jun 23.


IL-10+ Innate-like B Cells Are Part of the Skin Immune System and Require α4β1 Integrin To Migrate between the Peritoneum and Inflamed Skin.

Geherin SA, Gómez D, Glabman RA, Ruthel G, Hamann A, Debes GF.

J Immunol. 2016 Mar 15;196(6):2514-25. doi: 10.4049/jimmunol.1403246. Epub 2016 Feb 5.


T Cell Receptor-induced Nuclear Factor κB (NF-κB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry.

Liu X, Berry CT, Ruthel G, Madara JJ, MacGillivray K, Gray CM, Madge LA, McCorkell KA, Beiting DP, Hershberg U, May MJ, Freedman BD.

J Biol Chem. 2016 Apr 15;291(16):8440-52. doi: 10.1074/jbc.M115.713008. Epub 2016 Jan 29.


Ebola virus mediated infectivity is restricted in canine and feline cells.

Han Z, Bart SM, Ruthel G, Vande Burgt NH, Haines KM, Volk SW, Vite CH, Freedman BD, Bates P, Harty RN.

Vet Microbiol. 2016;182:102-7. doi: 10.1016/j.vetmic.2015.11.011. Epub 2015 Nov 17.


Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention.

Han Z, Madara JJ, Herbert A, Prugar LI, Ruthel G, Lu J, Liu Y, Liu W, Liu X, Wrobel JE, Reitz AB, Dye JM, Harty RN, Freedman BD.

PLoS Pathog. 2015 Oct 29;11(10):e1005220. doi: 10.1371/journal.ppat.1005220. eCollection 2015 Oct.


Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming.

Srinivasan S, Guha M, Dong DW, Whelan KA, Ruthel G, Uchikado Y, Natsugoe S, Nakagawa H, Avadhani NG.

Oncogene. 2016 Mar 24;35(12):1585-95. doi: 10.1038/onc.2015.227. Epub 2015 Jul 6.


The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target.

Madara JJ, Han Z, Ruthel G, Freedman BD, Harty RN.

Future Virol. 2015 May;10(5):537-546.


ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress.

Han Z, Madara JJ, Liu Y, Liu W, Ruthel G, Freedman BD, Harty RN.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S138-45. doi: 10.1093/infdis/jiu838. Epub 2015 Mar 18.


Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD.

Zwack EE, Snyder AG, Wynosky-Dolfi MA, Ruthel G, Philip NH, Marketon MM, Francis MS, Bliska JB, Brodsky IE.

MBio. 2015 Feb 17;6(1):e02095-14. doi: 10.1128/mBio.02095-14.


Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

Han Z, Lu J, Liu Y, Davis B, Lee MS, Olson MA, Ruthel G, Freedman BD, Schnell MJ, Wrobel JE, Reitz AB, Harty RN.

J Virol. 2014 Jul;88(13):7294-306. doi: 10.1128/JVI.00591-14. Epub 2014 Apr 16.


Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations.

Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD.

PLoS One. 2014 Mar 5;9(3):e90390. doi: 10.1371/journal.pone.0090390. eCollection 2014.


A host-oriented inhibitor of Junin Argentine hemorrhagic fever virus egress.

Lu J, Han Z, Liu Y, Liu W, Lee MS, Olson MA, Ruthel G, Freedman BD, Harty RN.

J Virol. 2014 May;88(9):4736-43. doi: 10.1128/JVI.03757-13. Epub 2014 Feb 12.


Mitochondrial retrograde signaling induces epithelial-mesenchymal transition and generates breast cancer stem cells.

Guha M, Srinivasan S, Ruthel G, Kashina AK, Carstens RP, Mendoza A, Khanna C, Van Winkle T, Avadhani NG.

Oncogene. 2014 Nov 6;33(45):5238-50. doi: 10.1038/onc.2013.467. Epub 2013 Nov 4.


Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis.

Novais FO, Carvalho LP, Graff JW, Beiting DP, Ruthel G, Roos DS, Betts MR, Goldschmidt MH, Wilson ME, de Oliveira CI, Scott P.

PLoS Pathog. 2013;9(7):e1003504. doi: 10.1371/journal.ppat.1003504. Epub 2013 Jul 18.


Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway.

Garrison AR, Radoshitzky SR, Kota KP, Pegoraro G, Ruthel G, Kuhn JH, Altamura LA, Kwilas SA, Bavari S, Haucke V, Schmaljohn CS.

Virology. 2013 Sep;444(1-2):45-54. doi: 10.1016/j.virol.2013.05.030. Epub 2013 Jun 19.


Host IQGAP1 and Ebola virus VP40 interactions facilitate virus-like particle egress.

Lu J, Qu Y, Liu Y, Jambusaria R, Han Z, Ruthel G, Freedman BD, Harty RN.

J Virol. 2013 Jul;87(13):7777-80. doi: 10.1128/JVI.00470-13. Epub 2013 May 1.


CD44 Promotes intoxication by the clostridial iota-family toxins.

Wigelsworth DJ, Ruthel G, Schnell L, Herrlich P, Blonder J, Veenstra TD, Carman RJ, Wilkins TD, Van Nhieu GT, Pauillac S, Gibert M, Sauvonnet N, Stiles BG, Popoff MR, Barth H.

PLoS One. 2012;7(12):e51356. doi: 10.1371/journal.pone.0051356. Epub 2012 Dec 7.


Therapeutic inhibition of pro-inflammatory signaling and toxicity to staphylococcal enterotoxin B by a synthetic dimeric BB-loop mimetic of MyD88.

Kissner TL, Ruthel G, Alam S, Mann E, Ajami D, Rebek M, Larkin E, Fernandez S, Ulrich RG, Ping S, Waugh DS, Rebek J Jr, Saikh KU.

PLoS One. 2012;7(7):e40773. doi: 10.1371/journal.pone.0040773. Epub 2012 Jul 27.

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