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Am J Gastroenterol. 2015 Nov;110(11):1539-48. doi: 10.1038/ajg.2015.296. Epub 2015 Sep 29.

Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta-Analysis.

Author information

1
Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
2
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
3
Max Healthcare, Gurgaon, India.
4
Medical Services Division, Innlandet Hospital Trust, Lillehammer, Norway.
5
Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.

Abstract

OBJECTIVES:

First-degree relatives (FDRs) of patients with celiac disease (CD) are at high risk for CD and prevalence among them varies from 1.6 to 38%. The risk of having CD among FDRs if the FDR is sister, brother, mother, father, son, or daughter of index patient with CD is not known. We conducted a meta-analysis and calculated pooled prevalence of CD among FDRs, second-degree relatives (SDRs), and specific relations with index patient.

METHODS:

On search of literature, 2,259 articles appeared of which 54 articles were included in this meta-analysis. Diagnosis of CD was based on standard criteria.

RESULTS:

Pooled prevalence of CD was 7.5% (95% confidence interval (CI) 6.3%, 8.8%) in 10,252 FDRs and 2.3% (95% CI 1.3%, 3.8%) in 642 SDRs. Pooled prevalence of CD was highest in siblings (8.9%), followed by offsprings (7.9%) and parents (3.0%). Female FDRs had higher prevalence than male FDRs (8.4% vs. 5.2%, P=0.047). While sisters and daughters of index patient had the highest risk of having CD (1 in 7 and 1 in 8, respectively), the risk was 1 in 13 in sons, 1 in 16 in brothers, 1 in 32 in mothers, and 1 in 33 in fathers. There were also differences in the pooled prevalence of CD in FDRs according to their geographic location.

CONCLUSIONS:

Pooled prevalence of CD among FDRs is 7.5% and varies considerably with their relationship with the index patient. The risk of CD in FDRs also varies according to gender and geographical location.

PMID:
26416192
DOI:
10.1038/ajg.2015.296
[Indexed for MEDLINE]

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