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Items: 1 to 20 of 37


secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids.

de Mena L, Chhangani D, Fernandez-Funez P, Rincon-Limas DE.

Fly (Austin). 2017 Feb 6:0. doi: 10.1080/19336934.2017.1291104. [Epub ahead of print]


Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila.

Fernandez-Funez P, Sanchez-Garcia J, de Mena L, Zhang Y, Levites Y, Khare S, Golde TE, Rincon-Limas DE.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):E5212-21. doi: 10.1073/pnas.1608045113.


A single amino acid (Asp159) from the dog prion protein suppresses the toxicity of the mouse prion protein in Drosophila.

Sanchez-Garcia J, Jensen K, Zhang Y, Rincon-Limas DE, Fernandez-Funez P.

Neurobiol Dis. 2016 Nov;95:204-9. doi: 10.1016/j.nbd.2016.07.025.


Data set of interactomes and metabolic pathways of proteins differentially expressed in brains with Alzheimer׳s disease.

Minjarez B, Calderón-González KG, Valero Rustarazo ML, Herrera-Aguirre ME, Labra-Barrios ML, Rincon-Limas DE, Sánchez Del Pino MM, Mena R, Luna-Arias JP.

Data Brief. 2016 May 6;7:1707-19. doi: 10.1016/j.dib.2016.04.071.


Identification of proteins that are differentially expressed in brains with Alzheimer's disease using iTRAQ labeling and tandem mass spectrometry.

Minjarez B, Calderón-González KG, Rustarazo ML, Herrera-Aguirre ME, Labra-Barrios ML, Rincon-Limas DE, Del Pino MM, Mena R, Luna-Arias JP.

J Proteomics. 2016 Apr 29;139:103-21. doi: 10.1016/j.jprot.2016.03.022.


Anti-Aβ single-chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease.

Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, de Mena L, Khare S, Golde TE, Levites Y, Rincon-Limas DE.

Hum Mol Genet. 2015 Nov 1;24(21):6093-105. doi: 10.1093/hmg/ddv321.


Modeling the complex pathology of Alzheimer's disease in Drosophila.

Fernandez-Funez P, de Mena L, Rincon-Limas DE.

Exp Neurol. 2015 Dec;274(Pt A):58-71. doi: 10.1016/j.expneurol.2015.05.013. Review.


KCNC3(R420H), a K(+) channel mutation causative in spinocerebellar ataxia 13 displays aberrant intracellular trafficking.

Gallego-Iradi C, Bickford JS, Khare S, Hall A, Nick JA, Salmasinia D, Wawrowsky K, Bannykh S, Huynh DP, Rincon-Limas DE, Pulst SM, Nick HS, Fernandez-Funez P, Waters MF.

Neurobiol Dis. 2014 Nov;71:270-9. doi: 10.1016/j.nbd.2014.08.020.


Launching Hsp70 neuroprotection: two drugs better than one.

Fernandez-Funez P, Rincon-Limas DE.

Cell Cycle. 2014;13(11):1657-8. doi: 10.4161/cc.29148. No abstract available.


Combined pharmacological induction of Hsp70 suppresses prion protein neurotoxicity in Drosophila.

Zhang Y, Casas-Tinto S, Rincon-Limas DE, Fernandez-Funez P.

PLoS One. 2014 Feb 11;9(2):e88522. doi: 10.1371/journal.pone.0088522.


Polar substitutions in helix 3 of the prion protein produce transmembrane isoforms that disturb vesicle trafficking.

Sanchez-Garcia J, Arbelaez D, Jensen K, Rincon-Limas DE, Fernandez-Funez P.

Hum Mol Genet. 2013 Nov 1;22(21):4253-66. doi: 10.1093/hmg/ddt276.


p∆TubHA4C, a new versatile vector for constitutive expression in Drosophila.

Zhang Y, Arcia S, Perez B, Fernandez-Funez P, Rincon-Limas DE.

Mol Biol Rep. 2013 Sep;40(9):5407-15. doi: 10.1007/s11033-013-2639-7.


Purification of transcripts and metabolites from Drosophila heads.

Jensen K, Sanchez-Garcia J, Williams C, Khare S, Mathur K, Graze RM, Hahn DA, McIntyre LM, Rincon-Limas DE, Fernandez-Funez P.

J Vis Exp. 2013 Mar 15;(73):e50245. doi: 10.3791/50245.


Differential activation of the ER stress factor XBP1 by oligomeric assemblies.

Castillo-Carranza DL, Zhang Y, Guerrero-Muñoz MJ, Kayed R, Rincon-Limas DE, Fernandez-Funez P.

Neurochem Res. 2012 Aug;37(8):1707-17. doi: 10.1007/s11064-012-0780-7.


Drosophila models of proteinopathies: the little fly that could.

Rincon-Limas DE, Jensen K, Fernandez-Funez P.

Curr Pharm Des. 2012;18(8):1108-22. Review.


Pulling rabbits to reveal the secrets of the prion protein.

Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, Jensen K, Zou WQ, Rincon-Limas DE.

Commun Integr Biol. 2011 May;4(3):262-6. doi: 10.4161/cib.4.3.15054.


Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain.

Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, Fernandez-Funez P, Lee HG, Smith MA, Petersen RB, Guo JP.

J Biol Chem. 2011 Apr 29;286(17):15095-105. doi: 10.1074/jbc.M110.199356.


The ER stress factor XBP1s prevents amyloid-beta neurotoxicity.

Casas-Tinto S, Zhang Y, Sanchez-Garcia J, Gomez-Velazquez M, Rincon-Limas DE, Fernandez-Funez P.

Hum Mol Genet. 2011 Jun 1;20(11):2144-60. doi: 10.1093/hmg/ddr100.


Sequence-dependent prion protein misfolding and neurotoxicity.

Fernandez-Funez P, Zhang Y, Casas-Tinto S, Xiao X, Zou WQ, Rincon-Limas DE.

J Biol Chem. 2010 Nov 19;285(47):36897-908. doi: 10.1074/jbc.M110.174391.


Exploring prion protein biology in flies: genetics and beyond.

Rincon-Limas DE, Casas-Tinto S, Fernandez-Funez P.

Prion. 2010 Jan-Mar;4(1):1-8.

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