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Items: 1 to 20 of 48

1.

RCAN1 in the inverse association between Alzheimer's disease and cancer.

Fu Q, Wu Y.

Oncotarget. 2017 Dec 11;9(1):54-66. doi: 10.18632/oncotarget.23094. eCollection 2018 Jan 2.

2.

The neuronal and endocrine roles of RCAN1 in health and disease.

Peiris H, Keating DJ.

Clin Exp Pharmacol Physiol. 2018 Apr;45(4):377-383. doi: 10.1111/1440-1681.12884. Epub 2017 Nov 29.

PMID:
29094385
3.

Neurons Derived from Induced Pluripotent Stem Cells of Patients with Down Syndrome Reproduce Early Stages of Alzheimer's Disease Type Pathology in vitro.

Dashinimaev EB, Artyuhov AS, Bolshakov AP, Vorotelyak EA, Vasiliev AV.

J Alzheimers Dis. 2017;56(2):835-847. doi: 10.3233/JAD-160945.

PMID:
28059787
4.

Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells.

Lim S, Hwang S, Yu JH, Lim JW, Kim H.

Mol Nutr Food Res. 2017 May;61(5). doi: 10.1002/mnfr.201600530. Epub 2017 Feb 6.

PMID:
27928873
5.

Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway.

Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, Troncoso JC, Albert MS, Thambisetty M.

Mol Psychiatry. 2017 Jan;22(1):13-23. doi: 10.1038/mp.2016.206. Epub 2016 Nov 22.

6.

The regulator of calcineurin 1 increases adenine nucleotide translocator 1 and leads to mitochondrial dysfunctions.

Jiang H, Zhang C, Tang Y, Zhao J, Wang T, Liu H, Sun X.

J Neurochem. 2017 Jan;140(2):307-319. doi: 10.1111/jnc.13900. Epub 2016 Dec 20.

7.

Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer's Disease.

Asai M, Kinjo A, Kimura S, Mori R, Kawakubo T, Shirotani K, Yagishita S, Maruyama K, Iwata N.

Biol Pharm Bull. 2016;39(10):1646-1652.

8.

The calcineurin inhibitor Sarah (Nebula) exacerbates Aβ42 phenotypes in a Drosophila model of Alzheimer's disease.

Lee S, Bang SM, Hong YK, Lee JH, Jeong H, Park SH, Liu QF, Lee IS, Cho KS.

Dis Model Mech. 2016 Mar;9(3):295-306. doi: 10.1242/dmm.018069. Epub 2015 Dec 10.

9.

RCAN1 overexpression promotes age-dependent mitochondrial dysregulation related to neurodegeneration in Alzheimer's disease.

Wong H, Levenga J, Cain P, Rothermel B, Klann E, Hoeffer C.

Acta Neuropathol. 2015 Dec;130(6):829-43. doi: 10.1007/s00401-015-1499-8. Epub 2015 Oct 24.

10.

Global differential expression of genes located in the Down Syndrome Critical Region in normal human brain.

Montoya JC, Fajardo D, Peña A, Sánchez A, Domínguez MC, Satizábal JM, García-Vallejo F.

Colomb Med (Cali). 2014 Dec 30;45(4):154-61. eCollection 2014 Oct-Dec.

11.

Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.

Wu Y, Deng Y, Zhang S, Luo Y, Cai F, Zhang Z, Zhou W, Li T, Song W.

Neurobiol Aging. 2015 Jan;36(1):169-77. doi: 10.1016/j.neurobiolaging.2014.07.029. Epub 2014 Aug 7.

PMID:
25194880
12.

RCAN1 regulates mitochondrial function and increases susceptibility to oxidative stress in mammalian cells.

Peiris H, Dubach D, Jessup CF, Unterweger P, Raghupathi R, Muyderman H, Zanin MP, Mackenzie K, Pritchard MA, Keating DJ.

Oxid Med Cell Longev. 2014;2014:520316. doi: 10.1155/2014/520316. Epub 2014 Jun 9.

13.

Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target.

Wu Y, Ly PT, Song W.

Mol Neurobiol. 2014 Dec;50(3):1085-97. doi: 10.1007/s12035-014-8704-y. Epub 2014 Apr 22. Review.

PMID:
24752590
14.

RCAN1 overexpression exacerbates calcium overloading-induced neuronal apoptosis.

Sun X, Wu Y, Herculano B, Song W.

PLoS One. 2014 Apr 21;9(4):e95471. doi: 10.1371/journal.pone.0095471. eCollection 2014.

15.

Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain.

Perluigi M, Pupo G, Tramutola A, Cini C, Coccia R, Barone E, Head E, Butterfield DA, Di Domenico F.

Biochim Biophys Acta. 2014 Jul;1842(7):1144-53. doi: 10.1016/j.bbadis.2014.04.007. Epub 2014 Apr 13.

16.

Regulator of calcineurin 1 gene transcription is regulated by nuclear factor-kappaB.

Zheng L, Liu H, Wang P, Song W, Sun X.

Curr Alzheimer Res. 2014 Feb;11(2):156-64.

PMID:
24359503
17.
18.

Dyrk1A-mediated phosphorylation of RCAN1 promotes the formation of insoluble RCAN1 aggregates.

Song WJ, Song EA, Choi SH, Baik HH, Jin BK, Kim JH, Chung SH.

Neurosci Lett. 2013 Oct 25;554:135-40. doi: 10.1016/j.neulet.2013.08.066. Epub 2013 Sep 7.

PMID:
24021800
19.

Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease.

Ermak G, Davies KJA.

Free Radic Biol Med. 2013 Sep;62:47-51. doi: 10.1016/j.freeradbiomed.2013.01.016. Epub 2013 Jan 29. Review.

20.

Overexpression of RCAN1 isoform 4 in mouse neurons leads to a moderate behavioral impairment.

Bhoiwala DL, Koleilat I, Qian J, Beyer B, Hushmendy SF, Mathew A, Bhoiwala DL, Ferland RJ, Crawford DR.

Neurol Res. 2013 Jan;35(1):79-89. doi: 10.1179/1743132812Y.0000000117.

PMID:
23317802

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