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Items: 1 to 20 of 86


Crystal structure analysis of human serum albumin complexed with sodium 4-phenylbutyrate.

Kawai A, Yamasaki K, Enokida T, Miyamoto S, Otagiri M.

Biochem Biophys Rep. 2018 Jan 28;13:78-82. doi: 10.1016/j.bbrep.2018.01.006. eCollection 2018 Mar.


Novel histone deacetylase inhibitor AR-42 exhibits antitumor activity in pancreatic cancer cells by affecting multiple biochemical pathways.

Chen YJ, Wang WH, Wu WY, Hsu CC, Wei LR, Wang SF, Hsu YW, Liaw CC, Tsai WC.

PLoS One. 2017 Aug 22;12(8):e0183368. doi: 10.1371/journal.pone.0183368. eCollection 2017.


HDAC Inhibitor Conjugated Polymeric Prodrug Micelles for Doxorubicin Delivery.

Senevirathne SA, Washington KE, Miller JB, Biewer MC, Oupicky D, Siegwart DJ, Stefan MC.

J Mater Chem B. 2017 Mar 21;5(11):2106-2114. doi: 10.1039/C6TB03038F. Epub 2017 Feb 20.


Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of <i>CDKN1A</i>.

Halaburková A, Jendželovský R, Kovaľ J, Herceg Z, Fedoročko P, Ghantous A.

Clin Epigenetics. 2017 Jun 8;9:62. doi: 10.1186/s13148-017-0359-x. eCollection 2017.


ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate.

Ma W, Goldberg E, Goldberg J.

Elife. 2017 Jun 8;6. pii: e26624. doi: 10.7554/eLife.26624.


Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases.

Matsuhashi T, Sato T, Kanno SI, Suzuki T, Matsuo A, Oba Y, Kikusato M, Ogasawara E, Kudo T, Suzuki K, Ohara O, Shimbo H, Nanto F, Yamaguchi H, Saigusa D, Mukaiyama Y, Watabe A, Kikuchi K, Shima H, Mishima E, Akiyama Y, Oikawa Y, Hsin-Jung HO, Akiyama Y, Suzuki C, Uematsu M, Ogata M, Kumagai N, Toyomizu M, Hozawa A, Mano N, Owada Y, Aiba S, Yanagisawa T, Tomioka Y, Kure S, Ito S, Nakada K, Hayashi KI, Osaka H, Abe T.

EBioMedicine. 2017 Jun;20:27-38. doi: 10.1016/j.ebiom.2017.05.016. Epub 2017 May 13.


Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5.

Chen L, Wolff DW, Xie Y, Lin MF, Tu Y.

BMC Cancer. 2017 Mar 7;17(1):179. doi: 10.1186/s12885-017-3153-4.


The HDAC inhibitor AR42 interacts with pazopanib to kill trametinib/dabrafenib-resistant melanoma cells in vitro and in vivo.

Booth L, Roberts JL, Sander C, Lee J, Kirkwood JM, Poklepovic A, Dent P.

Oncotarget. 2017 Mar 7;8(10):16367-16386. doi: 10.18632/oncotarget.14829.


Benzyl isothiocyanate induces protective autophagy in human lung cancer cells through an endoplasmic reticulum stress-mediated mechanism.

Zhang QC, Pan ZH, Liu BN, Meng ZW, Wu X, Zhou QH, Xu K.

Acta Pharmacol Sin. 2017 Apr;38(4):539-550. doi: 10.1038/aps.2016.146. Epub 2017 Jan 23.


Sensitivity of osteosarcoma cells to HDAC inhibitor AR-42 mediated apoptosis.

Murahari S, Jalkanen AL, Kulp SK, Chen CS, Modiano JF, London CA, Kisseberth WC.

BMC Cancer. 2017 Jan 21;17(1):67. doi: 10.1186/s12885-017-3046-6.


TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment.

Jin X, Wu N, Dai J, Li Q, Xiao X.

Cancer Med. 2017 Feb;6(2):424-438. doi: 10.1002/cam4.977. Epub 2016 Dec 29.


FOXO4 expression is related to stem cell-like properties and resistance to treatment in diffuse large B-cell lymphoma.

Ryu KJ, Park C, Hong M, Ko YH, Kim WS, Kim SJ.

Oncotarget. 2017 Jan 10;8(2):2466-2476. doi: 10.18632/oncotarget.13690.


Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42.

Henderson SE, Ding LY, Mo X, Bekaii-Saab T, Kulp SK, Chen CS, Huang PH.

Neoplasia. 2016 Dec;18(12):765-774. doi: 10.1016/j.neo.2016.10.003. Epub 2016 Nov 25.


An update on the use of benzoate, phenylacetate and phenylbutyrate ammonia scavengers for interrogating and modifying liver nitrogen metabolism and its implications in urea cycle disorders and liver disease.

De Las Heras J, Aldámiz-Echevarría L, Martínez-Chantar ML, Delgado TC.

Expert Opin Drug Metab Toxicol. 2017 Apr;13(4):439-448. doi: 10.1080/17425255.2017.1262843. Epub 2016 Nov 28. Review.


Procaine Induces Epigenetic Changes in HCT116 Colon Cancer Cells.

Sabit H, Samy MB, Said OA, El-Zawahri MM.

Genet Res Int. 2016;2016:8348450. Epub 2016 Oct 24.


Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6<sup>-/-</sup> Mice.

Pomozi V, Brampton C, Szeri F, Dedinszki D, Kozák E, van de Wetering K, Hopkins H, Martin L, Váradi A, Le Saux O.

J Invest Dermatol. 2017 Mar;137(3):595-602. doi: 10.1016/j.jid.2016.10.035. Epub 2016 Nov 5.


Sodium phenylbutyrate antagonizes prostate cancer through the induction of apoptosis and attenuation of cell viability and migration.

Xu Y, Zheng S, Chen B, Wen Y, Zhu S.

Onco Targets Ther. 2016 May 12;9:2825-33. doi: 10.2147/OTT.S101794. eCollection 2016.


Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia.

Bohnert KR, Gallot YS, Sato S, Xiong G, Hindi SM, Kumar A.

FASEB J. 2016 Sep;30(9):3053-68. doi: 10.1096/fj.201600250RR. Epub 2016 May 20.


AR-42 induces apoptosis in human hepatocellular carcinoma cells via HDAC5 inhibition.

Zhang M, Pan Y, Dorfman RG, Chen Z, Liu F, Zhou Q, Huang S, Zhang J, Yang D, Liu J.

Oncotarget. 2016 Apr 19;7(16):22285-94. doi: 10.18632/oncotarget.8077.

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