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Items: 1 to 20 of 425

1.

Proposal of a liver histology-based scoring system for bile salt export pump deficiency.

Zen Y, Kondou H, Nakazawa A, Tanikawa K, Hasegawa Y, Bessho K, Imagawa K, Ishige T, Inui A, Suzuki M, Kasahara M, Yamamoto K, Yoshioka T, Kage M, Hayashi H.

Hepatol Res. 2020 Feb 19. doi: 10.1111/hepr.13494. [Epub ahead of print]

PMID:
32073700
2.

A Multiaction and Multitarget Ru(II)-Pt(IV) Conjugate Combining Cancer Activated Chemotherapy and Photodynamic Therapy to Overcome Drug Resistant Cancers.

Karges J, Yempala T, Tharaud M, Gibson D, Gasser G.

Angew Chem Int Ed Engl. 2020 Feb 4. doi: 10.1002/anie.201916400. [Epub ahead of print]

PMID:
32017379
3.

Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis.

Nakano S, Osaka S, Sabu Y, Minowa K, Hirai S, Kondou H, Kimura T, Azuma Y, Watanabe S, Inui A, Bessho K, Nakamura H, Kusano H, Nakazawa A, Tanikawa K, Kage M, Shimizu T, Kusuhara H, Zen Y, Suzuki M, Hayashi H.

Sci Rep. 2019 Nov 19;9(1):17075. doi: 10.1038/s41598-019-53628-x.

4.

The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII.

Andersen E, Chollet ME, Baroni M, Pinotti M, Bernardi F, Skarpen E, Sandset PM, Skretting G.

Cell Biosci. 2019 Aug 27;9:69. doi: 10.1186/s13578-019-0333-8. eCollection 2019.

5.

Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation.

Singh PK, Deorukhkar AA, Venkatesulu BP, Li X, Tailor R, Bomalaski JS, Krishnan S.

Mol Cancer Ther. 2019 Dec;18(12):2381-2393. doi: 10.1158/1535-7163.MCT-18-0708. Epub 2019 Aug 8.

PMID:
31395686
6.

[Survival analysis of 118 chronic lymphocytic leukemia patients with abnormal TP53 gene in the era of traditional immunochemotherapy].

Li XT, Zhu HY, Wang L, Xia Y, Liang JH, Wu JZ, Wu W, Cao L, Fan L, Xu W, Li JY.

Zhonghua Xue Ye Xue Za Zhi. 2019 May 14;40(5):378-383. doi: 10.3760/cma.j.issn.0253-2727.2019.05.006. Chinese.

PMID:
31207701
7.
8.

Histone deacetylase inhibitor, AR-42, exerts antitumor effects by inducing apoptosis and cell cycle arrest in Y79 cells.

Duan S, Gong X, Liu X, Cui W, Chen K, Mao L, Jun S, Zhou R, Sang Y, Huang G.

J Cell Physiol. 2019 Dec;234(12):22411-22423. doi: 10.1002/jcp.28806. Epub 2019 May 17.

PMID:
31102271
9.

Retraction: Antitumor Effects of a Novel Phenylbutyrate-based Histone Deacetylase Inhibitor, (S)-HDAC-42, in Prostate Cancer.

Kulp SK, Chen CS, Wang DS, Chen CY, Chen CS.

Clin Cancer Res. 2019 May 1;25(9):2940. doi: 10.1158/1078-0432.CCR-19-0731. No abstract available.

PMID:
31043388
10.

Synthesis, cytotoxicity, apoptosis and molecular docking studies of novel phenylbutyrate derivatives as potential anticancer agents.

Mostoufi A, Baghgoli R, Fereidoonnezhad M.

Comput Biol Chem. 2019 Jun;80:128-137. doi: 10.1016/j.compbiolchem.2019.03.008. Epub 2019 Mar 28.

PMID:
30952039
11.

Histone Deacetylase Inhibitors and Anaplastic Thyroid Carcinoma.

Spartalis E, Athanasiadis DI, Chrysikos D, Spartalis M, Boutzios G, Schizas D, Garmpis N, Damaskos C, Paschou SA, Ioannidis A, Tsourouflis G, Dimitroulis D, Nikiteas NI.

Anticancer Res. 2019 Mar;39(3):1119-1127. doi: 10.21873/anticanres.13220. Review.

PMID:
30842140
12.

An Anticancer PtIV Prodrug That Acts by Mechanisms Involving DNA Damage and Different Epigenetic Effects.

Kostrhunova H, Petruzzella E, Gibson D, Kasparkova J, Brabec V.

Chemistry. 2019 Apr 5;25(20):5235-5245. doi: 10.1002/chem.201805626. Epub 2019 Mar 18.

PMID:
30740808
13.

Comprehensive Genetic Search to Clarify the Molecular Mechanism of Drug Resistance Identifies ASCL2-LEF1/TSPAN8 Axis in Colorectal Cancer.

Tanaka T, Kojima K, Yokota K, Tanaka Y, Ooizumi Y, Ishii S, Nishizawa N, Yokoi K, Ushiku H, Kikuchi M, Kojo K, Minatani N, Katoh H, Sato T, Nakamura T, Sawanobori M, Watanabe M, Yamashita K.

Ann Surg Oncol. 2019 May;26(5):1401-1411. doi: 10.1245/s10434-019-07172-7. Epub 2019 Jan 31.

PMID:
30706227
14.

ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer.

Guo L, Ma L, Liu C, Lei Y, Tang N, Huang Y, Huang G, Li D, Wang Q, Liu G, Tang M, Jing Z, Deng Y.

Oncol Rep. 2019 Mar;41(3):1603-1615. doi: 10.3892/or.2018.6943. Epub 2018 Dec 19.

15.

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats.

Corman A, Jung B, Häggblad M, Bräutigam L, Lafarga V, Lidemalm L, Hühn D, Carreras-Puigvert J, Fernandez-Capetillo O.

Cell Chem Biol. 2019 Feb 21;26(2):235-243.e5. doi: 10.1016/j.chembiol.2018.10.020. Epub 2018 Dec 6.

PMID:
30527999
16.

Ligand binding to human prostaglandin E receptor EP4 at the lipid-bilayer interface.

Toyoda Y, Morimoto K, Suno R, Horita S, Yamashita K, Hirata K, Sekiguchi Y, Yasuda S, Shiroishi M, Shimizu T, Urushibata Y, Kajiwara Y, Inazumi T, Hotta Y, Asada H, Nakane T, Shiimura Y, Nakagita T, Tsuge K, Yoshida S, Kuribara T, Hosoya T, Sugimoto Y, Nomura N, Sato M, Hirokawa T, Kinoshita M, Murata T, Takayama K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T.

Nat Chem Biol. 2019 Jan;15(1):18-26. doi: 10.1038/s41589-018-0131-3. Epub 2018 Dec 3.

PMID:
30510193
17.

The effect of combined treatment with sodium phenylbutyrate and cisplatin, erlotinib, or gefitinib on resistant NSCLC cells.

Al-Keilani MS, Alzoubi KH, Jaradat SA.

Clin Pharmacol. 2018 Oct 9;10:135-140. doi: 10.2147/CPAA.S174074. eCollection 2018.

18.

Cucurbitacin I induces cancer cell death through the endoplasmic reticulum stress pathway.

Li H, Chen H, Li R, Xin J, Wu S, Lan J, Xue K, Li X, Zuo C, Jiang W, Zhu L.

J Cell Biochem. 2018 Sep 11. doi: 10.1002/jcb.27570. [Epub ahead of print]

PMID:
30277611
19.

Synergistic activity of imatinib and AR-42 against chronic myeloid leukemia cells mainly through HDAC1 inhibition.

Wei D, Lu T, Ma D, Yu K, Zhang T, Xiong J, Wang W, Zhang Z, Fang Q, Wang J.

Life Sci. 2018 Oct 15;211:224-237. doi: 10.1016/j.lfs.2018.09.040. Epub 2018 Sep 22.

PMID:
30248347
20.

Inhibition of glioma growth by flavokawain B is mediated through endoplasmic reticulum stress induced autophagy.

Wang J, Qi Q, Zhou W, Feng Z, Huang B, Chen A, Zhang D, Li W, Zhang Q, Jiang Z, Bjerkvig R, Prestegarden L, Thorsen F, Wang X, Li X, Wang J.

Autophagy. 2018;14(11):2007-2022. doi: 10.1080/15548627.2018.1501133. Epub 2018 Aug 17.

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