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Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A.

Halaburková A, Jendželovský R, Kovaľ J, Herceg Z, Fedoročko P, Ghantous A.

Clin Epigenetics. 2017 Jun 8;9:62. doi: 10.1186/s13148-017-0359-x. eCollection 2017.


ER retention is imposed by COPII protein sorting and attenuated by 4-phenylbutyrate.

Ma W, Goldberg E, Goldberg J.

Elife. 2017 Jun 8;6. pii: e26624. doi: 10.7554/eLife.26624.


A Patient with MSUD: Acute Management with Sodium Phenylacetate/Sodium Benzoate and Sodium Phenylbutyrate.

Köse M, Canda E, Kagnici M, Uçar SK, Çoker M.

Case Rep Pediatr. 2017;2017:1045031. doi: 10.1155/2017/1045031. Epub 2017 May 15.


4-phenylbutyrate Mitigates Fluoride-Induced Cytotoxicity in ALC Cells.

Suzuki M, Everett ET, Whitford GM, Bartlett JD.

Front Physiol. 2017 May 11;8:302. doi: 10.3389/fphys.2017.00302. eCollection 2017.


A chemical chaperone improves muscle function in mice with a RyR1 mutation.

Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL.

Nat Commun. 2017 Mar 24;8:14659. doi: 10.1038/ncomms14659.


The endoplasmic reticulum stress/autophagy pathway is involved in cholesterol-induced pancreatic β-cell injury.

Kong FJ, Wu JH, Sun SY, Zhou JQ.

Sci Rep. 2017 Mar 15;7:44746. doi: 10.1038/srep44746.


Identification of enzymes involved in oxidation of phenylbutyrate.

Palir N, Ruiter JPN, Wanders RJA, Houtkooper RH.

J Lipid Res. 2017 May;58(5):955-961. doi: 10.1194/jlr.M075317. Epub 2017 Mar 9.


Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5.

Chen L, Wolff DW, Xie Y, Lin MF, Tu Y.

BMC Cancer. 2017 Mar 7;17(1):179. doi: 10.1186/s12885-017-3153-4.


Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells.

Imagawa K, Takayama K, Isoyama S, Tanikawa K, Shinkai M, Harada K, Tachibana M, Sakurai F, Noguchi E, Hirata K, Kage M, Kawabata K, Sumazaki R, Mizuguchi H.

Sci Rep. 2017 Feb 2;7:41806. doi: 10.1038/srep41806.


Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress.

Guo Q, Xu L, Li H, Sun H, Liu J, Wu S, Zhou B.

Lipids Health Dis. 2017 Jan 31;16(1):25. doi: 10.1186/s12944-017-0425-6.


TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment.

Jin X, Wu N, Dai J, Li Q, Xiao X.

Cancer Med. 2017 Feb;6(2):424-438. doi: 10.1002/cam4.977. Epub 2016 Dec 29.


FOXO4 expression is related to stem cell-like properties and resistance to treatment in diffuse large B-cell lymphoma.

Ryu KJ, Park C, Hong M, Ko YH, Kim WS, Kim SJ.

Oncotarget. 2017 Jan 10;8(2):2466-2476. doi: 10.18632/oncotarget.13690.


Suppression of Tumor Growth and Muscle Wasting in a Transgenic Mouse Model of Pancreatic Cancer by the Novel Histone Deacetylase Inhibitor AR-42.

Henderson SE, Ding LY, Mo X, Bekaii-Saab T, Kulp SK, Chen CS, Huang PH.

Neoplasia. 2016 Dec;18(12):765-774. doi: 10.1016/j.neo.2016.10.003. Epub 2016 Nov 25.


Procaine Induces Epigenetic Changes in HCT116 Colon Cancer Cells.

Sabit H, Samy MB, Said OA, El-Zawahri MM.

Genet Res Int. 2016;2016:8348450. Epub 2016 Oct 24.


Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork.

Kasetti RB, Phan TN, Millar JC, Zode GS.

Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6058-6069. doi: 10.1167/iovs.16-19610.


Averting the foul taste of pediatric medicines improves adherence and can be lifesaving - Pheburane<sup>®</sup> (sodium phenylbutyrate).

Koren G, Rieder MJ, Amitai Y.

Patient Prefer Adherence. 2016 Oct 21;10:2141-2144. eCollection 2016. Review.


Endoplasmic reticulum stress-induced neuronal inflammatory response and apoptosis likely plays a key role in the development of diabetic encephalopathy.

Wang Z, Huang Y, Cheng Y, Tan Y, Wu F, Wu J, Shi H, Zhang H, Yu X, Gao H, Lin L, Cai J, Zhang J, Li X, Cai L, Xiao J.

Oncotarget. 2016 Nov 29;7(48):78455-78472. doi: 10.18632/oncotarget.12925.


Bipolar and Related Disorders Induced by Sodium 4-Phenylbutyrate in a Male Adolescent with Bile Salt Export Pump Deficiency Disease.

Vitale G, Simonetti G, Pirillo M, Taruschio G, Andreone P.

Psychiatry Investig. 2016 Sep;13(5):580-582. Epub 2016 Sep 30.

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